Effects of HIV infection on the immune system

  • J. Steven McDougal
  • Janet K. A. Nicholson
  • Alison Mawle
Chapter

Abstract

The acquired immune deficiency syndrome (AIDS) is characterized by progressive lymphopenia, predominantly of T helper/inducer cells, which renders the patient susceptible to a variety of opportunistic infections and malignancies. AIDS itself remains a clinical diagnosis and is but one manifestation of a spectrum of clinical and subclinical immunologic disorders caused by the human immunodeficiency virus (HIV), also known as HTLV-III, LAV, or ARV (Barré-Sinoussi et al., 1983; Gallo et al., 1984; Levy et al., 1984; Coffin et al, 1986).

Keywords

Human Immunodefieieney Virus Human Immunodefieieney Virus Infection Aequired Immune Defieieney Syndrome Acquire Immunodeficiency Syndrome Immune Deficiency Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Abrams, D. I., Lewis, B. J., Beckstead, J. H., Casavant, C. A. and Drew, W. L. (1984) Persistent diffuse lymphadenopathy in homosexual men: endpoint or prodrome? Ann. Intern. Med., 100, 801–8.PubMedGoogle Scholar
  2. Alocer-Varela, J., Alarcon-Segovia, D. and Abud-Mendoza, C. (1985) Immuno-regulatory circuits in the acquired immune deficiency syndrome and related complex. Production of and response to interleukins 1 and 2, NK function and its enhancement by interleukin-2 and kinetics of the autologous mixed lymphocyte reactions. Clin. Exp. Immunol., 60, 31–8.Google Scholar
  3. Ammann, A. J., Abrams, D., Conant, M., Chudwin, D., Cowan, M., Volberding, P., Lewis, B. and Casavant, C. (1983) Acquired immune dysfunction in homosexual men: immunologic profiles. Clin. Immunol. Immunopath., 27, 315–25.Google Scholar
  4. Ammann, A. J., Schiffman, G., Abrams, D., Volberding, P., Ziegler, J. and Conant, M. (1984) B-cell immunodeficiency syndrome in acquired immune deficiency syndrome. JAMA, 251, 1447–9.PubMedGoogle Scholar
  5. Armstrong, J. A. and Horne, R. (1985) Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy. Lancet, ii, 370–2.Google Scholar
  6. Arya, S. K. and Gallo, R. C. (1985) Human T cell growth factor (interleukin 2) and α-interferon genes: expression in human T lymphotropic virus type III and type I cells. Proc. Natl Acad. Sci. USA, 82, 8691–5.PubMedGoogle Scholar
  7. Bank, I. and Chess, L. (1985) Perturbation of the T4 molecule transmits a negative signal to T cells. J. Exp. Med., 162, 1294–303.PubMedGoogle Scholar
  8. Barin, F., McLane, M. F., Allan, J. S., Lee T. H., Groopman, J. E. and Essex, M. (1985) Virus envelope protein of HTLV-III represents major target antigen for antibodies in AIDS patients. Science, 228, 1094–6.PubMedGoogle Scholar
  9. Barré-Sinoussi, F., Chermann, J. C., Rey, F., Nugeyre, M. T., Charmarat, S., Gruest, J., Dauguet, C., Axler-Blin, C., Vezinet-Brun, F., Rouzioux, C., Rozenbaum, W. and Montagnier, L. (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for the acquired immunodeficiency syndrome (AIDS). Science, 220, 868–71.PubMedGoogle Scholar
  10. Bender, B. S., Quinn, T. C., Lawley, T. J., Smith, W., Brickman, C. and Frank, M. M. (1984) Acquired immune deficiency syndrome: a defect in Fc-receptor specific clearance. Clin. Res., 32, 511 A.Google Scholar
  11. Bender, B. S., Arger, F. A., Quinn, T. C., Redfield, R., Gold, J., and Folks, T. M. (1986) Impaired antibody-dependent cell-mediated cytotoxic activity acquired immunodeficiency syndrome. Clin. Exp. Immunol., 64, 166–72.PubMedGoogle Scholar
  12. Benveniste, E., Schroff, R., Stevens, R. H. and Gottlieb, M. S. (1983) Immunoregulatory T cells in men with a new acquired immunodeficiency syndrome. J. Clin. Immunol., 3, 359–67.PubMedGoogle Scholar
  13. Biddison, W. E., Rao, P. E., Talle, M. A., Goldstein, G. and Shaw, S. (1984) Possible involvement of the T4 molecule in T cell recognition of class II HLA antigens. J. Exp. Med., 159, 783–97.PubMedGoogle Scholar
  14. Biggar, R. J., Taylor, P. H., Goldstein, A. L., Melbye, M., Ebbesen, P., Mann, D. L. and Strong, D. M. (1983) Thymosin α1 levels and helper: suppressor ratios in homosexual men. N. Engl. J. Med., 309, 49.PubMedGoogle Scholar
  15. Biggar, R. J., Melbye, M., Ebbesen, P., Alexander, S., Nielsen, J. O., Sarin, P. and Faber, V. (1985) Variation in HTLV-III antibodies in homosexual men: decline before onset of illness related to acquired immune deficiency syndrome (AIDS). Brit. Med. J., 291, 997–8.Google Scholar
  16. Birx, D. L., Redfield, R. R. and Tosato, G. (1986) Defective regulation of Epstein-Barr virus infection in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related disorders. N. Engl. J. Med., 314, 874–9.PubMedGoogle Scholar
  17. Boumpas, D., Harris, C., Hooks, J., Popovic, M. and Mann, D. (1984) A human T cell lymphoma virus infected B lymphocyte line produces acid labile interferon alpha. Clin. Res., 32, 343A.Google Scholar
  18. Chan, W. C., Brynes, R. K., Spira, T. J., Banks, P. M., Thurmond, C. C., Ewing, E. P. and Chandler, F. W. (1985) Lymphocyte subsets in lymph nodes of homosexual men with generalized lymphadenopathy correlation with morphology and blood changes. Arch. Pathol. Lab. Med., 107, 133–7.Google Scholar
  19. Ciobanu, N., Weite, K., Kruger, G., Venuta, S., Gold, J., Feldman, S. P., Wang, C. Y., Koziner, B., Moore, M. A. S., Safai, B. and Mertelsmann, R. (1983) Defective T-cell response to PHA and mitogenic monoclonal antibodies in male homosexuals with acquired immunodeficiency syndrome and its in vitro correction by interleukin 2. J. Clin. Immunol, 3, 332–40.PubMedGoogle Scholar
  20. Clement, L. T., Grossi, C. E. and Gartland, L. J. (1984) Morphologic and phenotypic features of the subpopulation of Leu2+ cells that suppresses B cell differentiation. J. Immunol, 133, 2461–8.PubMedGoogle Scholar
  21. Clement, L. T., Dagg, M. K. and Landay, A. (1984) Characterization of human lymphocyte subpopulations: alloreactive cytotoxic T lymphocyte precursor and effector cells are phenotypically distinct from Leu2+ suppressor cells. J. Clin. Immunol, 4, 395–402.PubMedGoogle Scholar
  22. Coffin, J., Haase, A., Levy, J. A., Montagnier, L., Oroszlan, S., Teich, N., Temin, H., Toyoshima, K., Varmus, H., Vogt, P. and Weiss, R. (1986) Human immunodeficiency viruses. Science, 232, 697.PubMedGoogle Scholar
  23. Cooper, D. A., Gold, J., Maclean, P., Donovan, B., Finlyason, R., Barnes, T. G., Michelmore, H. M., Brooke, P. and Penny, R. (1985) Acute AIDS retrovirus infection: definition of a clinical illness associated with seroconversion. Lancet, i, 537–40.Google Scholar
  24. Crawford, D. H., Weiler, I. and Iliescu, V. (1984) Polyclonal activation of B cells in homosexual men. N. Engl. J. Med., 311, 536–7.Google Scholar
  25. Creemers, P. C., Stark, D. F. and Boyko, W. J. (1985) Evaluation of natural killer cell activity in patients with persistent generalized lymphadenopathy and acquired immune deficiency syndrome. Clin. Immunol. Immunopathol., 36, 141–50.PubMedGoogle Scholar
  26. Cunningham-Rundles, S., Michelis, M. A. and Masur, H. (1983) Serum suppression of lymphocyte activation in vitro in acquired immune deficiency syndrome. N. Engl. J. Med., 310, 1279–82.Google Scholar
  27. Curran, J. W. (1983) AIDS-two years later. N. Engl. J. Med., 309, 609–10.PubMedGoogle Scholar
  28. Dalgleish, A. G., Beverely, P. C. L., Clapham, P. R., Crawford, D. H., Greaves, M. F. and Weiss, R. A. (1985) The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature, Lond., 312, 763–7.Google Scholar
  29. Dalgleish, A. G. and Clapham, P. (1985) B cells in the pathogenesis of AIDS. Immunol. Today, 6, 71.Google Scholar
  30. Elie, R., Laroche, A. C., Arnous, E., Guerin, J.-M., Pierre, G. and Malebauche, R. (1983) Thymic dysplasia in acquired immunodeficiency syndrome (Haiti). N. Engl. J. Med., 308, 841–2.PubMedGoogle Scholar
  31. Eyster, M. E., Goedert, J. J., Poon, M.-C. and Preble, O. T. (1983) Acid-labile alpha interferon. A possible preclinical marker for the acquired immunodeficiency syndrome in hemophilia. N. Engl. J. Med., 309, 583–6.PubMedGoogle Scholar
  32. Eyster, M. E., Goedert, J. J., Sarnagadharan, M. G., Weiss, S. H., Gallo, R. C. and Blattner, W. A. (1985) Development and early natural history of HTLV-III antibodies in persons with hemophilia. JAMA, 253, 2219–23.PubMedGoogle Scholar
  33. Fahey, J. L., Prince, H., Weaver, M. M., Groopman, J., Visscher, B., Schwartz, K. and Detels, R. (1984) Quantitative changes in the Th or Ts lymphocyte subsets that distinguish AIDS syndromes from other immune subset disorders. Am. J. Med., 76, 95–100.PubMedGoogle Scholar
  34. Fauci, A. S. (1984a) Immunologic abnormalities in the acquired immunodeficiency syndrome (AIDS). Clin. Res., 32, 491–9.PubMedGoogle Scholar
  35. Fauci, A. S., Macher, H., Longo, D. L., Lane, H. C., Masur, M. and Gelman, E. P. (1984b) Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations. Ann. Intern. Med., 100, 92–106.PubMedGoogle Scholar
  36. Fauci, A. S., Masur, H., Gelmann, E. P., Markham, P. D., Hahn, B. H. and Lane, H. C. (1985) The acquired immunodeficiency syndrome: an update. Ann. Intern. Med., 102, 800–13.PubMedGoogle Scholar
  37. Feorino, P. M., Kalyanaraman, V. S., Haverkos, H. W., Cabradilla, C. D., Warfield, D. T., Jaffe, H. W., Harrison, A. K., Gottlieb, M. S., Goldfinger, D., Chermann, J.-C., Barre-Sinoussi, F., Spira, T. J., McDougal, J. S., Curran, J. W., Montagnier, L., Murphy, F. A. and Francis, D. P. (1984) Lymphadenopathy-associated virus (LAV) infection of a blood donor-recipient pair with acquired immunodeficiency syndrome (AIDS). Science, 225, 69–72.PubMedGoogle Scholar
  38. Feorino, P. M., Jaffe, H. W., Palmer, E., Peterman, T. A., Francis, D. P., Kalyanaraman, V. S., Weistein, R. A., Stoneburner, R. L., Alexander, W. J., Raevskey, C., Getchell, J. P., Warfield, D., Haverkos, H. W., Kilbourne, B. W., Nicholson, J. K. A. and Curran, J. W. (1985) Transfusion-associated AIDS: evidence for persistent infection in blood donors. N. Engl. J. Med., 312, 1293–6.PubMedGoogle Scholar
  39. Fishbein, D. B., Kaplan, J. E., Spira, T. J., Miller, B., Schonberger, L. B., Pinsky, P. F., Getchell, J. P., Kalyanaraman, V. S. and Braude, J. S. (1985) Unexplained lymphadenopathy in homosexual men: a longitudinal study. JAMA, 254, 930–5.PubMedGoogle Scholar
  40. Fisher, A. G., Collalti, E., Ratner, L., Gallo, R. C. and Wong-Staal, F. (1985) A molecular clone of HTLV-III with biological activity. Nature, Lond., 316, 262–5.Google Scholar
  41. Fitzgerald, P. A., von Wussow, P. and Lopez, C. (1982) Role of interferon in natural kill of HSV-1-infected fibroblasts. J. Immunol., 129, 819–23.PubMedGoogle Scholar
  42. Folks, T., Benn, S., Rabson, A., Theodore, T., Hoggan, M. D., Martin, M., Lightfoote, M. and Sell, K. (1985) Characterization of a continuous T-cell line susceptible to the cytopathic effect of the AIDS-associated virus. Proc. Natl Acad. Sci. USA, 82, 4539–43.PubMedGoogle Scholar
  43. Friedman, S. R., Des Jarlais, D. C., Marmor, D., Yancovitz, S., Zolla-Pazner, S., El-Sadr, W., Cohen, H., Garber, J., Spira, T. J. and Beatrice, S. (1986) HTLV-III/ LAV, in vivo immunologic stimulation, and T4 cell loss, submitted.Google Scholar
  44. Friedman-Kein, A. E., Laubenstein, L., Dubin, R., Marmor, M. and Zolla-Pazner, S. (1982) Disseminated Kaposi’s sarcoma in homosexual men. Ann. Intern. Med., 96, 693–700.Google Scholar
  45. Gallo, R. C., Salahuddin, S. Z., Popovic, M., Shearer, A. M., Kaplan, M., Haynes, B. F., Palker, T. J., Redfield, R., Oleske, J., Safai, B., White, G., Foster, P. and Markham, P. D. (1984) Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science, 224, 500–2.PubMedGoogle Scholar
  46. Gatenby, P. A., Kausas, G. S., Xian, G. Y., Evans, R. L. and Engleman, E. G. (1982) Dissection of immunoregulatory subpopulations of T lymphocytes within the helper and suppressor sublineages in man. J. Immunol., 129, 1997–2000.PubMedGoogle Scholar
  47. Gerstoft, J., Dickmeiss, E. and Mathiesen, L. (1985) Cytotoxic capabilities of lymphocytes from patients with the acquired immune deficiency syndrome. Scand. J. Immunol., 22, 463–70.PubMedGoogle Scholar
  48. Gidlund, M., Orn, A., Wigzell, H., Senik, A. and Gresser, I. (1978) Enhanced NK cell activity in mice injected with interferon inducers. Nature, Lond., 273, 759–61.Google Scholar
  49. Gluckman, J.-C., Kaltzmann, D., Cavaille-Coll, M., Brisson, E., Messiah, A., Lachiver, D. and Rozenbaum, W. (1985) Is there correlation of T cell proliferative functions and surface marker phenotypes in patients with acquired immune deficiency syndrome or lymphadenopathy syndrome? Clin. Exp. Immunol., 60, 8–16.PubMedGoogle Scholar
  50. Goedert, J. J., Sarngadharan, M. G., Biggar, R. J., Weiss, S. H., Winn, D., Grossman, R. J., Greene, M. H., Bodner, A., Mann, D. L., Strong, D. M., Gallo, R. C. and Blattner, W. A. (1984) Determinants of retrovirus (HTLV-III) antibody and immunodeficiency conditions in homosexual men. Lancet, ii, 711–16.Google Scholar
  51. Goedert, J. J., Biggar, R. J., Weiss, S. H., Eyster, M. E., Melbye, M., Wilson, S., Ginzburg, H. M., Grossman, R. J., DiGiola, R. A., Sanchez, W. C., Giron, J. A., Ebbesen, P., Gallo, R. C. and Blattner, W. A. (1986) Three year incidence of AIDS in five cohorts of HTLV-III-infected risk group members. Science, 231, 992–7.PubMedGoogle Scholar
  52. Gottlieb, M. S., Schroff, R., Schanker, H. M., Weissman, D. O., Fan, P. T., Wolf, R. A. and Saxon, A. (1981) Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence for a new acquired cellular immunodeficiency. N. Engl. J. Med., 305, 1425–31.PubMedGoogle Scholar
  53. Gottlieb, M. S., Groopman, J. E., Weinstein, W. M., Fahey, J. L. and Detels, R. (1983) The acquired immunodeficiency syndrome. Ann. Intern. Med., 99, 208–20.PubMedGoogle Scholar
  54. Greene, W. C., Fleisher, T. A., Nelson, D. L. and Waldmann, T. A. (1982) Production of human suppressor T cell hybridomas. J. Immunol., 129, 1986–92.PubMedGoogle Scholar
  55. Grieco, M. H., Reddy, M. M., Kothari, H. B., Lange, M., Buimovici-Klein, E. and William, D. (1984) Elevated β2-microglobulin and lysozyme levels in patients with acquired immune deficiency syndrome. Clin. Immunol. Immunopathol., 32, 174–84.PubMedGoogle Scholar
  56. Groopman, J. E., Salahuddin, S. Z., Sarngadharan, M. B., Mullins, M. G., Sullivan, J. L., Mulder, C., O’Hara, C. J., Cheeseman, S. H., Haverkos, H., Forgacs, P., Riedel, N., McLane, M. F., Essex, M. and Gallo, R. C. (1984) Virologic studies in a case of transfusion-associated AIDS. N. Engl. J. Med., 311, 1419–22.PubMedGoogle Scholar
  57. Gupta, S. and Safai, B. (1983) Deficient autologous mixed lymphocyte reaction in Kaposi’s sarcoma associated with deficiency of Leu3+ responder cells. J. Clin. Invest., 71, 296–300.PubMedGoogle Scholar
  58. Gupta, S. and Licorish, K. (1984) Circulating immune complexes in AIDS. N. Engl. J. Med., 311, 1530–1.Google Scholar
  59. Gyorkey, F., Meinich, J. L., Sinkovics, J. G. and Gyorkey, P. (1985) Retrovirus resembling HTLV in macrophages of patients with AIDS. Lancet, i, 106.Google Scholar
  60. Hauser, G. J., Bino, T., Rosenberg, H., Zakuth, V., Geller, E. and Spirer, Z. (1984) Interleukin-2 production and response to exogenous interleukin-2 in a patient with the acquired immune deficiency syndrome (AIDS). Clin. Exp. Immunol., 56, 14–17.PubMedGoogle Scholar
  61. Heagy, W., Kelley, V. E., Strom, T. B., Mayer, K., Shapiro, H. M., Mandel, R. and Finberg, R. (1984) Decreased expression of human Class II antigens on monocytes from patients with acquired immune deficiency syndrome. Increased expression with interferon-γ. J. Clin. Invest., 74, 2089–96.PubMedGoogle Scholar
  62. Hersch, E. M., Reuben, J. M., Rios, A., Mansell, W. A., Newell, G. R., McClure, J. E. and Goldstein, A. L. (1983) Elevated serum thymosin α1 levels associated with evidence of immune dysregulation in male homosexuals with a history of infectious diseases or Kaposi’s sarcoma. N. Engl. J. Med., 308, 45–6.Google Scholar
  63. Ho, D. D., Rota, T. R., Schooley R. T., Kaplan, J. C., Allan, J. D., Groopman, J. E., Resnich, L., Felsenstein, D., Andrews, C. A. and Hirsch, M. S. (1985a) Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N. Engl. J. Med., 313, 1493–7.PubMedGoogle Scholar
  64. Ho, D. D., Hartshorn, K. L., Rota, T. R., Andrews, C. A., Kaplan, J. C., Schooley, R. T. and Hirsch, M. S. (1985b) Recombinant human interferon alpha-A suppresses HTLV-III replication in vitro. Lancet, i, 602–4.Google Scholar
  65. Ho, D. D., Rota, T. R. and Hirsch, M. S. (1986) Infection of monocyte/macrophages by human T lymphotropic virus type III. J. Clin. Invest., 77, 1712–15.PubMedGoogle Scholar
  66. Hoxie, J. A., Haggarty, B. S., Rackowski, J. L., Pillsbury, N. and Levy, J. A. (1985) Persistent noncytopathic infection of normal human lymphocytes with AIDS-associated retrovirus. Science, 229, 1400–2.PubMedGoogle Scholar
  67. Incefy, G. S., Dardenne, M., Pahwa, S., Grimmes, E., Pahwa, R. N., Smithwich, E., O’Reilly, R. and Good, R. A. (1977) Thymic activity in severe combined immunodeficiency diseases. Proc. Natl Acad. Sci., 74, 1250–3.PubMedGoogle Scholar
  68. Isobe, M., Huecner, K., Maddon, P. J., Littman, D. R., Axel, R., Crobe, C. M. (1986) Proc. Natl Acad. Sci. USA, 83, 4399–402.PubMedGoogle Scholar
  69. Jaffe, H. W., Feorino, P. M., Darrow, W. W., O’Malley, P. M., Getchell, J. P., Warfield, D. T., Jones, B. M., Echenberg, D. F., Francis, D. P. and Curran, J. W. (1985) Persistent infection with HTLV-III/LAV in apparently healthy homosexual men. Ann. Intern. Med., 102, 627–8.PubMedGoogle Scholar
  70. Jason, J., McDougal, J. S., Holman, R. C., Stein, S. F., Lawrence, D. N., Nicholson, J. K. A., Dixon, G., Doxey, M. and Evatt, B. L. (1985) HTLV-III/LAV-associated antibody: association with hemophiliacs immune status and blood component usage. JAMA, 753, 3409–15.Google Scholar
  71. Joshi, V. V. and Oleske, J. M. (1985) Pathologic appraisal of the thymus gland in acquired immunodeficiency syndrome in children. Arch. Pathol. Lab. Med., 109, 142–6.PubMedGoogle Scholar
  72. Jothy, S., Gilmore, N., El’Gabalaway, H. and Purchal, J. (1985) Decreased population of Leu7+ natural killer cells in lymph nodes of homosexual men with AIDS-related persistent lymphadenopathy. Can. Med. Assoc. J., 132, 141–4.PubMedGoogle Scholar
  73. Kaminsky, L. S., McHugh, T., Stites, D., Volberding, P., Henle, G., Henle, W. and Levy, J. A. (1985) High prevalence of antibodies to acquired immune deficiency syndrome (AIDS)-associated retrovirus (ARV) in AIDS and related conditions but not in other disease states. Proc. Natl Acad. Sci. USA, 82, 5535–9.PubMedGoogle Scholar
  74. Kitchen, L., Malone, G., Orgad, S., Barin, F., Zaizov, R., Ramot, B., Gazit, E., Kreiss, J., Leal, M., Wichmann, I., Martinowitz, U. and Essex, M. (1986) Viral envelope protein of HTLV-III is the major target antigen for antibodies in hemophiliac patients. J. Infect. Dis., 153, 788–90.PubMedGoogle Scholar
  75. Klatzmann, D., Barre-Sinoussi, F., Nugeyre, M. T., Dauguet, C., Vilmer, E., Griscelli, C., Brun-Vezinet, F., Rouzioux, C., Gluckman, J. C., Chermann, J.-C. and Montagnier, L. (1984) Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes. Science, 225, 59–62.PubMedGoogle Scholar
  76. Klatzmann, D., Champagne, E., Charmarat, S., Gruest, J., Guetard, D., Hercend, T., Gluckman, J.-C. and Montagnier, L. (1985) T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature, Lond., 312, 767–8.Google Scholar
  77. Kolata, G. (1986) Where is the AIDS virus harbored?. Science, 232, 1197.Google Scholar
  78. Landesman, S. H., Ginzburg, H. M. and Weiss, S. H. (1985) The AIDS epidemic. N. Engl. J. Med., 312, 521–3.PubMedGoogle Scholar
  79. Lane, H. C., Masur, H., Edgar, L. C., Whalen, G., Rook, A. H. and Fauci, A. S. (1983) Abnormalities of B cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med., 309, 453–8.PubMedGoogle Scholar
  80. Lane, H. C. and Fauci, A. S. (1985) Immunologic abnormalities in the acquired immunodeficiency syndrome. Ann. Rev. Immunol., 3, 477–500.Google Scholar
  81. Lane, H. C., Masur, H., Gelmann, E. P., Longo, D. L., Steis, R. G., Chused, T., Whalen, G., Edgar, L. and Fauci, A. S. (1985a) Correlation between immunologic function and clinical subpopulations of patients with the acquired immune deficiency syndrome. Am. J. Med., 78, 417–22.PubMedGoogle Scholar
  82. Lane, H. C., Depper, J. M., Greene, W. C., Whalen, G., Waldmann, T. A. and Fauci, A. S. (1985b) Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med., 313, 79–84.PubMedGoogle Scholar
  83. Lanier, L. L., Le, A. M., Phillips, J. H., Warner, N. L. and Babcock, G. F. (1983) Subpopulations of human natural killer cells defined by expression of the Leu7 (HNK-1) and Leull (NK-15) antigens. J. Immunol., 131, 1789–96.PubMedGoogle Scholar
  84. Lanier, L. L. and Loken, M. R. (1984) Human lymphocyte subpopulations identified by using three-color immunofluorescence and flow cytometry analysis: correlation of Leu2, Leu3, Leu7, Leu8, and Leull cell surface antigen expression. J. Immunol., 132, 151–6.PubMedGoogle Scholar
  85. Laurence, J., Gottlieb, A. B. and Kunkel, H. G. (1983) Soluble suppressor factors in patients with acquired immune deficiency syndrome and its prodrome. Elaboration in vitro by T lymphocyte-adherent cell interactions. J. Clin. Invest., 72, 2072–81.PubMedGoogle Scholar
  86. Laurence, J. and Mayer, L. (1984) Immunoregulatory lymphokines of T hybridomas from AIDS patients: constitutive and inducible suppressor factors. Science, 225, 66–9.PubMedGoogle Scholar
  87. Ledbetter, J. A., Evans, R. L., Lipinski, M., Cunningham-Rundles, C., Good, R. A. and Herzenberg, L. A. (1981) Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man. J. Exp. Med., 153, 310–23.PubMedGoogle Scholar
  88. Lederman, M. M., Ratnoff, O. D., Evatt, B. L. and McDougal, J. S. (1985) Acquisition of antibody to lymphadenopathy-associated virus in patients with classic hemophilia (Factor VIII deficiency). 102, 753–7.Google Scholar
  89. Levy, J. A., Hoffman, A. D., Kramer, S. M., Landis, J. A., Shimabukuro, J. M. and Oschiro, L. S. (1984) Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. Science, 225, 840–2.PubMedGoogle Scholar
  90. Levy, J. A., Kaminsky, L. S., Morrow, J. W., Steimer, K., Luciw, P., Dina, D., Hoxie, J. and Oshiro, L. (1985a) Infection by the retrovirus associated with the acquired immunodeficiency syndrome. Ann. Intern. Med., 103, 694–9.PubMedGoogle Scholar
  91. Levy, J. A., Shimabukuro, J., McHugh, T., Casavant, C., Stites, D. P. and Oshiro, L. S. (1985b) AIDS-associated retroviruses (ARV) can productively infect other cells besides human T helper cells. Virology, 147, 441–8.PubMedGoogle Scholar
  92. Levy, J. A., Shimabukuro, J., Hollander, H., Mills, J. and Kaminsky, L. (1985c) Isolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurological symptoms. Lancet, ii, 586–8.Google Scholar
  93. Levy, J. A., Cheng-Mayer, C., Dina, D. and Luciw, P. A. (1986) AIDS retrovirus (ARV-2) clone replicates in transfected human and animal fibroblasts. Science, 232, 998–1000.PubMedGoogle Scholar
  94. Lewis, D. E., Puck, J. M., Babcock, G. F. and Rich, R. R. (1985) Disproportionate expansion of a minor T cell subset in patients with lymphadenopathy syndrome and acquired immune deficiency syndrome. J. Infect. Dis., 151, 555–9.PubMedGoogle Scholar
  95. Lifson, J. D., Mark, D. F., Benike, C. J., Koths, K. and Engleman, E. G. (1984) Human recombinant interleukin-2 partly reconstitutes deficient in vitro immune responses of lymphocytes from patients with AIDS. Lancet, i, 698–702.Google Scholar
  96. Lifson, J. D., Reyes, G. R., McGrath, M. S., Stein, B. S. and Engleman, E. G. (1986) AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen. Science, 232, 1123–6.PubMedGoogle Scholar
  97. Lightfoote, M. M., Folks, T. M. and Sell, K. W. (1984) Analysis of immune complex components isolated from serum of AIDS patients. Fed. Proc, 43, 1921.Google Scholar
  98. Lopez, C., Fitzgerald, P. A. and Siegal, F. P. (1983) Severe acquired immune deficiency syndrome in male homosexuals: diminished capacity to make interferon-a in vitro associated with severe opportunistic infections. J. Infect. Dis., 148, 962–6.PubMedGoogle Scholar
  99. Martin, L. S., McDougal, J. S., Spira, T. J. and Loskoski, S. L. (1986) Cell surface pheno-type of the spontaneous immunoglobulin-secreting cells in peripheral blood from homosexual men with generalized lymphadenopathy. Diag. Immunol., 4, 117–23.Google Scholar
  100. Masur, H., Michelis, M. A., Greene, J., Onorato, I., Vande Stouwe, R. A., Holtzman, R. S., Wormser, G., Brettman, L., Lange, M., Murray, H. W. and Cunningham-Rundles, S. (1981) An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N. Engl. J. Med., 305, 1431–8.PubMedGoogle Scholar
  101. Mathur-Wagh, U., Enlow, R. E., Spigland, I., Winchester, R. J., Sacks, H. S., Rorat, E., Yancovitz, S. R., Klein, M. J., William, D. C. and Mildvan, D. (1984) Longitudinal study of persistent generalized lymphadenopathy in homosexual men: relation to AIDS. Lancet, i, 1033–7.Google Scholar
  102. Mawle, A. C., Scheppler-Campbell, J. A. and McDougal, J. S. (1985) Regression as a measure of EBV-specific T cell cytotoxicity in AIDS, AIDS-related complex, and normal homosexual men compared with heterosexual controls. Ann. Intern. Med., 103, 777.Google Scholar
  103. McDougal, J. S., Cort, S. P., Kennedy, M. S., Cabradilla, C. D., Feorino, P. M., Francis, D. P., Hicks, D., Kalyanaraman, V. S. and Martin, L. S. (1985a) Immunoassay for the detection and quantitation of infectious human retrovirus, lymphadenopathy-associated virus (LAV). J. Immunol. Methods, 76, 171–83.PubMedGoogle Scholar
  104. McDougal, J. S., Mawle, A., Cort, S. P., Nicholson, J. K. A., Cross, G. D., Scheppler-Campbell, J. A., Hicks, D. and Sligh, J. (1985b) Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 molecule. J. Immunol., 135, 3151–62.PubMedGoogle Scholar
  105. McDougal, J. S., Hubbard, M., Nicholson, J. K. A., Jones, B. M., Holman, R. C., Roberts, J., Fishbein, D. B., Jaffe, H. W., Kaplan, J. E., Spira, T. J. and Evatt, B. L. (1985c) Immune complexes in the acquired immunodeficiency syndrome (AIDS): relationship to disease manifestation, risk group, and immunologic defect. J. Clin. Immunol., 5, 130–8.PubMedGoogle Scholar
  106. McDougal, J. S., Kennedy, M. S., Sligh, J. M., Cort, S. P., Mawle, A. and Nicholson, J. K. A. (1986a) Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule. Science, 231, 382–5.PubMedGoogle Scholar
  107. McDougal, J. S., Nicholson, J. K. A., Cross, G. D., Kennedy, M. S., Cort, S. P., Rao, P., Goldstein, L., Goldstein, G. and Mawle, A. (1986b) Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry. J. Immunol., 137, 2937–44.PubMedGoogle Scholar
  108. Melbye, M., Biggar, R. J., Ebbesen, P., Sarngadharan, M. G., Weiss, S. H., Gallo, R. C. and Blattner, W. A. (1984) Seroepidemiology of HTLV-III antibody in Danish homosexual men: prevalence, transmission, and disease outcome. Brit. Med. J., 289, 573–5.Google Scholar
  109. Melbye, M., Biggar, R. J., Ebbesen, P., Neuland, C., Goedert, J. J., Faber, V., Lorenzen, I., Skinhoj, P., Gallo, R. C. and Blattner, W. A. (1986) Long-term seropositivity for human T-lymphotropic virus type III in homosexual men without the acquired immunodeficiency syndrome: development of immunologic and clinical abnormalities. Ann. Intern. Med., 104, 496–500.PubMedGoogle Scholar
  110. Metroka, C. E., Cunningham-Rundles, S., Pollack, M. S., Sonnabend, J. A., Davis, J. M., Gordon, B., Fernandez, R. D. and Mouradian, J. (1983) Generalized lymphadenopathy in homosexual men. Ann. Intern. Med., 99, 585–91.PubMedGoogle Scholar
  111. Meuer, S. C., Schlossman, S. F. and Reinherz, E. L. (1982) Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc. Natl Acad. Sci. USA, 79, 4395–9.PubMedGoogle Scholar
  112. Mildvan, D., Mathur, U., Enlow, R. W., Roman, P. L., Winchester, R. J., Colp, C., Singman, H., Adelsberg, B. R. and Spigland, I. (1982) Opportunistic infections and immune deficiency in homosexual men. Ann. Intern. Med., 96, 700–4.PubMedGoogle Scholar
  113. Modlin, R. L., Meyer, P. R., Hofman, F. M., Mehlmauer, M., Levy, N. B., Lukes, R. J., Parker, J. W., Ammann, A. J., Conant, M. A., Rea, T. H. and Taylor, C. R. (1983) T-lymphocyte subsets in lymph nodes from homosexual men. JAMA, 250, 1302–5.PubMedGoogle Scholar
  114. Montagnier, L., Gruest, J., Charmaret, S., Dauguet, C., Axler, C., Guetard, D., Nugeyre, M. T., Barre-Sinoussi, F., Chermann, J. C., Brunet, J. B., Klatzmann, D. and Gluckman, J. C. (1984) Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B-lymphoblastoid cell lines. Science, 225, 63–7.PubMedGoogle Scholar
  115. Montagnier, L., Clavel, F., Krust, B., Charmaret, S., Rey, F., Barre-Sinoussi, F. and Chermann, J. C. (1985) Identification and antigenicity of the major envelope glycoprotein of lymphadenopathy-associated virus. Virology, 141, 283–9.Google Scholar
  116. Morris, L., Distenfeld, A., Amorosi, E. and Karpatkin, S. (1982) Autoimmune thrombocytopenic purpura in homosexual men. Ann. Intern. Med., 96, 714–17.PubMedGoogle Scholar
  117. Murray, H. W., Rubin, B. Y., Masur, H. and Roberts, R. B. (1984) Impaired production of lymphokines and immune (gamma) interferon in the acquired-immunodeficiency syndrome. N. Engl. J. Med., 310, 883–9.PubMedGoogle Scholar
  118. Murray, H. W., Weite, K., Jacobs, J. L., Rubin, B. Y., Mertelsmann, R. and Roberts, R. B. (1985) Production of and in vitro response to interleukin 2 in the acquired immunodeficiency syndrome. J. Clin. Invest., 76, 1959–64.PubMedGoogle Scholar
  119. Nicholson, J. K. A., McDougal, J. S., Spira, T. J., Cross, G. D., Jones, B. M. and Reinherz, E. L. (1984) Immunoregulatory subsets of the T helper and T suppressor cell population in homosexual men with chronic unexplained lymphadenopathy. J. Clin. Invest., 73, 191–201.PubMedGoogle Scholar
  120. Nicholson, J. K. A., McDougal, J. S. and Spira, T. J. (1985a) Alterations of functional subsets of T helper and T suppressor cell populations in acquired immunodeficiency syndrome (AIDS) and chronic unexplained lymphadenopathy. J. Clin. Immunol, 5, 269–74.PubMedGoogle Scholar
  121. Nicholson, J. K. A., McDougal, J. S., Jaffe, H. W., Spira, T. J., Kennedy, M. S., Jones, B. M., Darrow, W. W., Morgan, M. and Hubbard, M. (1985b) Exposure to human T-lymphotropic virus type III/lymphadenopathy associated virus and immunologic abnormalities in asymptomatic homosexual men. Ann. Intern. Med., 103, 37–42.PubMedGoogle Scholar
  122. Nicholson, J. K. A., Cross, G. D., Callaway, C. S. and McDougal, J. S. (1986a) In vitro infection of human monocytes with human T-lymphotropic virus type III/lym-phadenopathy-associated virus (HTLV-III/LAV). J. Immunol., 137, 323–9.PubMedGoogle Scholar
  123. Nicholson, J. K. A., Echenberg, D. F., Jones, B. M., Jaffe, H. W., Feorino, P. M. and McDougal, J. S. (1986b) T cytotoxic/suppressor cell phenotypes in a group of asymptomatic homosexual men with and without exposure to HTLV-III/LAV. Clin. Immunol. Immunopathol, 40, 505–14.PubMedGoogle Scholar
  124. Pahwa, S. G., Quilop, M. T. J., Lange, M., Pahwa, R. N. and Grieco, M. H. (1984) Defective B lymphocyte function in homosexual men in relation to the acquired immunodeficiency syndrome. Ann. Intern. Med., 101, 757–63.PubMedGoogle Scholar
  125. Pahwa, S., Pahwa, R., Saxinger, C., Gallo, R. C. and Good, R. A. (1985) Influence of the human T-lymphotropic virus/lymphadenopathy-associated virus on functions of human lymphocytes: Evidence for immunosuppressive effects and polyclonal B cell activation by banded viral preparations. Proc. Natl Acad. Sci. USA, 82, 8198–202.PubMedGoogle Scholar
  126. Pinching, A. J., McManus, T. J., Jeffries, D. J., Moshtael, O., Donaghy, M., Parkin, J. M., Munday, P. E. and Harris, J. R. W. (1983) Studies of cellular immunity in male homosexuals in London. Lancet, ii, 126–9.Google Scholar
  127. Poli, G., Introna, M., Zanaboni, F., Peri, G., Carbonari, M., Aiuti, F., Lazzarin, A., Moroni, M. and Mantovani, A. (1985a) Natural killer cells in intravenous drug abusers with lymphadenopathy syndrome. Clin. Exp. Immunol., 62, 128–35.PubMedGoogle Scholar
  128. Poli, G., Bottazzi, B., Acero, R., Bersani, L., Ross, V., Introna, M., Lazzarin, A., Galli, M. and Mantovani, A. (1985b) Monocyte function in intravenous drug abusers with lymphadenopathy syndrome and in patients with acquired immunodeficiency syndrome: selective impairment of Chemotaxis. Clin. Exp. Immunol., 62, 136–42.PubMedGoogle Scholar
  129. Popovic, M., Gallo, R. C. and Mann, D. L. (1984) OKT4 bearing molecule is a receptor for the human retrovirus HTLV-III. Clin. Res., 33, 560A.Google Scholar
  130. Popovic, M., Read-Connole, E. and Gallo, R. C. (1984) T4 positive human neoplastic cell lines susceptible to and permissive for HTLV-III. Lancet, ii, 1472.Google Scholar
  131. Prince, H. E., Kermani-Arab, V. and Fahey, J. L. (1984) Depressed interleukin-2 receptor expression in acquired immunodeficiency and lymphadenopathy syndromes. J. Immunol., 133, 1313–17.PubMedGoogle Scholar
  132. Prince, H. E., Kressi, J. K., Kasper, C. K., Kleinman, S., Saunders, A. M., Waldbeser, L., Manding, O. O. and Kaplan, H. S. (1985a) Distinctive lymphocyte subpopulation abnormalities in patients with congenital coagulation disorders who exhibit lymph node enlargement. Blood, 66, 64–8.PubMedGoogle Scholar
  133. Prince, H. E., Moody, D. J., Shubin, B. I. and Fahey, J. L. (1985b) Defective monocyte function in acquired immune deficiency syndrome (AIDS): evidence from a monocyte-dependent T-cell proliferative system. J. Clin. Immunol., 5, 21–5.PubMedGoogle Scholar
  134. Quinnan, G. V., Masur, H., Rook, A. H., Armstrong, G., Frederick, W. R., Epstein, I., Manischewitz, J. F., Macher, A. M., Jackson, L., Ames, J., Smith, H. A., Parker, M., Pearson, G. R., Parillo, J., Mitchell, C. and Strauss, S. E. (1984) Herpes virus infections in the acquired immune deficiency syndromes. JAMA, 252, 72–7.PubMedGoogle Scholar
  135. Rabson, A. B., Daugherty, D. F., Venkatesan, S., Boulukos, K. E., Benn, S., Folks, T. M., Feorino, P. M. and Martin, M. A. (1985) Transfection of novel open reading frame of AIDS retrovirus during infection of lymphocytes. Science, 229, 1388–90.PubMedGoogle Scholar
  136. Rao, T. K. S., Filippone, E. J., Nicastri, A. D., Landesman, S. H., Frank, E., Chen, C. K. and Friedman, E. A. (1984) Associated focal and segmental glomerulosclerosis in the acquired immunodeficiency syndrome. N. Engl. J. Med., 310, 669–73.PubMedGoogle Scholar
  137. Reddy, M. M., Pinyavat, N. and Greico, M. H. (1984) Interleukin 2 augmentation of natural killer cell activity in homosexual men with acquired immune deficiency syndrome. Infect. Immun., 44, 339–43.PubMedGoogle Scholar
  138. Redfield, R. R., Wright, D. C. and Tramont, E. C. (1986) The Walter Reed staging classifications for HTLV-III/LAV infection. N. Engl. J. Med., 314, 131–2.PubMedGoogle Scholar
  139. Reinherz, E. L., Kung, P. C., Goldstein, G. and Schlossman, S. F. (1979a) Separation of functional subsets of human T cells by a monoclonal antibody. Proc. Natl. Acad. Sci. USA, 76, 4061–5.PubMedGoogle Scholar
  140. Reinherz, E. L., Kung, P. C., Pesando, J. M., Ritz, J., Goldstein, G. and Schlossman, S. F. (1979b) la determinants on human T cell subsets defined by monoclonal antibody: activation stimuli required for expression. J. Exp. Med., 150, 1472–82.PubMedGoogle Scholar
  141. Reinherz, E. L. and Schlossman, S. F. (1980) The differentiation and function of human T lymphocytes. Cell, 19, 821–7.PubMedGoogle Scholar
  142. Reinherz, E. L., Morimoto, C., Penta, A. C. and Schlossman, S. F. (1981) Subpopulations of the T4+ inducer T cell subset in man: evidence for an amplifier population preferentially expressing la antigen upon activation. J. Immunol., 126, 67–70.PubMedGoogle Scholar
  143. Reinherz, E. L., Morimoto, C., Fitzgerald, K. A., Hussey, R. E., Daley, J. F. and Schlossman, S. F. (1982) Heterogeneity of human T4+ inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations. J. Immunol., 128, 463–8.PubMedGoogle Scholar
  144. Robert-Guroff, M., Brown, M. and Gallo, R. C. (1985) HTLV-III neutralizing antibodies in patients with AIDS and AIDS-related complex. Nature, Lond., 316, 72–4.Google Scholar
  145. Rogers, M. F., Morens, D. M., Stewart, J. A., Kaminski, R. M., Spira, T. J., Feorino, P. M., Larsen, S. A., Francis, D. P., Wilson, M. and Kaufman, L. (1983) National case-control study of Kaposi’s sarcoma and Pneumocystis carinii pneumonia in homosexual men: Part 2, laboratory results. Ann. Intern. Med., 99, 151–8.PubMedGoogle Scholar
  146. Rook, A. H., Masur, H., Lane, H. C., Frederick, W., Kasahara, T., Macher, A. M., Djeu, J. Y., Manischewitz, J. F., Jackson, L., Fauci, A. S. and Quinnan, G. V. (1983) Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome. J. Clin. Invest., 72, 398–403.PubMedGoogle Scholar
  147. Rook, A. H., Hooks, J. J., Quinnan, G. V., Lane, H. C., Manischewitz, J. F., Macher, A. M., Fauci, A. S. and Djeu, J. Y. (1985a) Interleukin 2 enhances the natural killer cell activity of acquired immunodeficiency syndrome patients through a a-interferon-independent mechanism. J. Immunol., 134, 1503–7.PubMedGoogle Scholar
  148. Rook, A. H., Manischewitz, J. F., Frederick, W. R., Epstein, J. S., Jackson, L., Gelmann, E., Steis, R., Masur, H. and Quinnan, G. V. (1985b) Deficient HLA-restricted, cytomegalovirus-specific cytotoxic T cells and natural killer cells in patients with the acquired immune deficiency syndrome. J. Infect. Dis., 152, 627–30.PubMedGoogle Scholar
  149. Rosen, C. A., Sodroski, J. G. and Haseltine, W. A. (1985) The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/ LAV) long terminal repeat. Cell, 41, 813–23.PubMedGoogle Scholar
  150. Rosen, F. S., Cooper, M. D. and Wedgewood, R. J. P. (1984) The primary immunodeficiencies (parts 1 and 2). N. Engl. J. Med., 311, 235–42, 300–10.PubMedGoogle Scholar
  151. Ruscetti, F. W., Mikouits, J. A., Kalyanaraman, V. S., Overton, R., Stevenson, H., Stromberg, K., Herberman, R. B., Farrar, W. L. and Ortaldo, J. R. (1986) Analysis of effector mechanisms against HTLV-I and HTLV-III/LAV infected lymphoid cells. J. Immunol., 136, 3619–24.PubMedGoogle Scholar
  152. Safai, B., Sarngadharan, M. G., Groopman, J. E., Arnett, K., Popovic, M., Slinski, A., Schupbach, J. and Gallo, R. C. (1984) Seroepidemiological studies of human T-lymphotropic retrovirus type III in acquired immunodeficiency syndrome. Lancet, i, 1438–40.Google Scholar
  153. Salahuddin, S. Z., Markham, P. D., Lindner, S. G., Gootenberg, J. and Popovic, M. (1984) Lymphokine production by cultured human T cells transformed by HTLV-I. Science, 223, 703–7.PubMedGoogle Scholar
  154. Salazar-Gonzales, J. F., Moody, D. J., Giorgi, J. V., Martinez-Maza, O., Mitsuyasu, R. T. and Fahey, J. L. (1985) Reduced ecto-5′-nucleotidase activity and enhanced OKTIO and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: Evidence of CD8 immaturity. J. Immunol, 135, 1778–85.Google Scholar
  155. Sarin, P. S., Sun, D. K., Thornton, A. H., Naylor, P. H. and Goldstein, A. L. (1986) Neutralization of HTLV-III/LAV replication by antiserum to thymosin α1. Science, 232, 1135–7.PubMedGoogle Scholar
  156. Sarngadharan, M. G., Popovic, M., Bruch, L., Schupbach, J. and Gallo, R. C. (1984) Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science, 224, 506–8.PubMedGoogle Scholar
  157. Schroff, R. W., Gottlieb, M. S., Prince, H. E., Chai, L. L. and Fahey, J. L. (1983) Immunological studies of homosexual men with immunodeficiency and Kaposi’s sarcoma. Clin. Immunol. Immunopathol., 27, 300–14.PubMedGoogle Scholar
  158. Schupbach, J., Haller, O., Vogt, M., Lathy, R., Joller, H., Oelz, O., Popovic, M., Sarngadharan, M. G. and Gallo, R. C. (1985) Antibodies to HTLV-III in Swiss patients with AIDS and pre-AIDS and in groups at risk for AIDS. N. Engl. J. Med., 312, 265–70.PubMedGoogle Scholar
  159. Schwartz, K., Visscher, B. R., Detels, R., Taylor, J., Nisharian, P. and Fahey, J. L. (1985) Immunological changes in lymphadenopathy virus positive and negative symptomless male homosexuals: two years of observation. Lancet, ii, 831–2.Google Scholar
  160. Sharma, B. and Gupta, S. (1985) Antigen-specific primary cytotoxic T lymphocyte (CTL) responses in acquired immune deficiency syndrome (AIDS) and AIDS-related complexes (ARC). Clin. Exp. Immunol., 62, 296–303.PubMedGoogle Scholar
  161. Shaw, G. M., Harper, M. E., Hahn, B. H., Epstein, L. G., Gajdusek, D. C., Price, R. W., Navia, B. A., Petito, C. K., O’Hara, C. J., Groopman, J. E., Cho, E.-S., Oleske, J. M., Wong-Staal, F. and Gallo, R. C. (1985) HTLV-III infection in brains of children and adults with AIDS encephalopathy. Science, 227, 177–82.PubMedGoogle Scholar
  162. Shearer, G. M., Salahuddin, S. Z., Markham, P. D., Joseph, L. J., Payne, S. M., Kriebel, P., Bernstein, D. C., Biddison, W. E., Sarngadharan, M. G. and Gallo, R. C. (1985) Prospective study of cytotoxic T lymphocyte responses to influenza and antibodies to human T lymphotropic virus-Ill in homosexual men. J. Clin. Invest., 76, 1699–1704.PubMedGoogle Scholar
  163. Siegal, F. P., Lopez, C., Hammer, G. S., Brown, A. E., Kornfeld, S. J., Gold, J., Hassett, J., Hirschman, S. Z., Cunningham-Rundles, C., Adelsberg, B. R., Parkham, D. M., Siegal, M., Cunningham-Rundles, S. and Armstrong, D. (1981) Severe acquired immunodeficiency in homosexual males, manifested by chronic perianal ulcerative herpes simplex lesions. N. Engl. J. Med., 305, 1439–44.PubMedGoogle Scholar
  164. Siegal, F. P., Lopez, C., Fitzgerald, P. A., Shah, K., Baron, P., Leiderman, I. Z., Imperato, D. and Landesman, S. (1986) Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity. J. Clin. Invest., in press.Google Scholar
  165. Siegel, J. P., Djeu, J. Y., Stocks, N. I., Masur, H., Fauci, A. S., Lane, H. C., Gelmann, E. P. and Quinnan, G. P. (1984) Serum from patients with the acquired immune deficiency syndrome suppresses production of interleukin-2 by normal peripheral blood lymphocytes. Clin. Res., 32, 358A.Google Scholar
  166. Smith, P. D., Ohura, K., Masur, H., Lane, H. C., Fauci, A. S. and Wahl, S. M. (1984) Monocyte function in the acquired immune deficiency syndrome: defective Chemotaxis. J. Clin. Invest., 74, 2121–8.PubMedGoogle Scholar
  167. Smolen, J. S., Bettelheim, P., Koller, U., McDougal, S., Graninger, W., Luger, T. A., Knapp, W. and Lechner, K. (1985) Deficiency of the autologous mixed lymphocyte reaction in patients with classic hemophilia treated with commercial factor VIII concentrate. J. Clin. Invest., 75, 1828–34.PubMedGoogle Scholar
  168. Sodroski, J., Patarca, R., Rosen, C., Wong-Staal, F. and Haseltine, W. (1985) Location of the transactivating region on the genome of human T-cell lymphotropic virus type III. Science, 229, 74–7.PubMedGoogle Scholar
  169. Sodroski, J., Goh, W. C., Rosen, C., Tartar, A., Porteteile, D., Burny, A. and Haseltine, W. (1986a) Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions. Science, 231, 1549–53.PubMedGoogle Scholar
  170. Sodroski, J., Goh, W. C., Rosen, C., Dayton, A., Terwilliger, E. and Haseltine, W. (1986b) A second post-transcriptional trans-activator gene required for HTLV-III replication, Nature, Lond., 321, 412–17.Google Scholar
  171. Stahl, R. E., Friedman-Kein, A. E., Dubin, R., Marmor, M. and Zolla-Pazner, S. (1982) Immunologic abnormalities in homosexual men: relationship to Kaposi’s sarcoma. Am. J. Med., 73, 171–8.PubMedGoogle Scholar
  172. Stein, S. F., Evatt, B. L., McDougal, J. S., Lawrence, D. N., Holman, R. C., Ramsey, R. B. and Spira, T. J. (1985) A longitudinal study of patients with hemophilia: immunologic correlates of infection with HTLV-III/LAV and other viruses. Blood, 66, 973–9.PubMedGoogle Scholar
  173. Stites, D. P., Casavant, C. H., McHugh, T. M., Moss, A. R., Beal, S. L., Ziegler, J. L., Saunders, A. M. and Warner, N. L. (1986) Flow cytometric analysis of lymphocyte phenotypes in AIDS using monoclonal antibodies and simultaneous dual immunofluorescence. Clin. Immunol. Immunopathol., 38, 161–77.PubMedGoogle Scholar
  174. Tersmette, M., Van Dongen, J. J. M., De Goede, R. E. Y., Van Kessel, A. G., Huisman, H. G. and Miedema, F. (1986) T4+ human-murine T cell hybrids cannot be productively infected with HTLV-III. International AIDS Conference, Paris, June 21–3.Google Scholar
  175. Thomas, Y., Rogozinski, L., Irigoyen, O. H., Shen, H. H., Talle, M. A., Goldstein, G. and Chess, L. (1982) Functional analysis of human T cell subsets defined by monoclonal antibodies. V. Suppressor cells within the activated OKT4+ population belong to a distinct subset. J. Immunol., 128, 1386–90.PubMedGoogle Scholar
  176. Tomar, R. H., John, P. A., Hennig, A. K. and Kloster, B. (1985) Cellular targets of antilymphocyte antibodies in AIDS and LAS. Clin. Immunol. Immunopathol., 37, 37–47.PubMedGoogle Scholar
  177. Tsoukas, C., Gervais, F., Shuster, J., Gold, P., O’Shaughnessy, M. and Robert-Guroff, M. (1984) Association of HTLV-III antibodies and cellular immune status of hemophiliacs. N. Engl. J. Med., 311, 1514–15.PubMedGoogle Scholar
  178. Wachter, H., Fuchs, D., Hausen, A., Huber, C., Kuosp, O., Reibnegger, G. and Spira, T. J. (1983) Elevated urinary neopterin levels in patients with the acquired immunodeficiency syndrome (AIDS). Hoppe-Seyler’s Z. Physiol. Chem., 364, 1345–6.PubMedGoogle Scholar
  179. Wallace, L. E., Moss, D. J., Rickinson, A. B., McMichael, A. J. and Epstein, M. A. (1981) Cytotoxic T cell recognition of Epstein-Barr virus-infected cells. II. Blocking studies with monoclonal antibodies to HLA determinants. Eur. J. Immunol., 11, 694–9.PubMedGoogle Scholar
  180. Washburn, R. G., Tuazon, C. U. and Bennett, J. E. (1984) Phagocytic and fungicidal activity of monocytes from patients with acquired immunodeficiency syndrome. J. Infect. Dis., 151, 565–6.Google Scholar
  181. Weiss, R. A., Clapham, P. R., Cheingsong-Popov, R., Dalgleish, A. G., Carne, C. A., Weiler, I. V. D. and Tedder, R. S. (1985) Neutralization of human T-lymphotropic virus type HI by sera of AIDS and AIDS-risk patients. Nature, Lond., 316, 69–72.Google Scholar
  182. Williams, R. C., Masur, H. and Spira, T. J. (1984) Lymphocyte-reactive antibodies in acquired immune deficiency syndrome. J. Clin. Immunol., 4, 118–23.PubMedGoogle Scholar
  183. Wong-Staal, F. and Gallo, R. C. (1985) Human T-lymphotropic retroviruses. Nature, Lond., 317, 395–403.Google Scholar
  184. Wood, G. S., Warner, N. L. and Warke, R. A. (1983) Anti-Leu3/T4 antibodies react with cells of monocyte/macrophage and Langerhans lineage. J. Immunol., 131, 212–16.PubMedGoogle Scholar
  185. Wood, G. S., Burnes, B. F., Dorfman, R. F. and Warnke, R. A. (1986) In situ quantitation of lymph node helper, suppressor, and cytotoxic T cell subsets in AIDS. Blood, 67, 596–603.PubMedGoogle Scholar
  186. Yachie, A., Miyawaki, T., Yokoi, T., Nagaoki, T. and Taniguchi, N. (1982) 1α positive cells generated by PWM-stimulation within the OKT4+ subset interact with OKT8+ cells for inducing active suppression on B cell differentiation in vitro. J. Immunol., 129, 103–6.PubMedGoogle Scholar
  187. Zagury, D., Bernard, J., Leonard, R., Cheynier, R., Feldman, M., Sarin, P. S. and Gallo, R. C. (1986) Long-term cultures of HTLV-III infected T cells: a model of cytopathology of T cell depletion in AIDS. Science, 231, 850–3.PubMedGoogle Scholar
  188. Ziegler-Heitbrock, H. W. L., Schramm, W., Satchel, D., Rumpold, H., Kraft, D., Wernicke, D., Von Der Helm, K., Eberle, J., Deinhardt, F., Rieber, G. P. and Rietmuller, G. (1985) Expansion of a minor subpopulation of peripheral blood lymphocytes (T8+/Leu7+) in patients with hemophilia, Clin. Exp. Immunol., 61, 633–41.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1987

Authors and Affiliations

  • J. Steven McDougal
  • Janet K. A. Nicholson
  • Alison Mawle

There are no affiliations available

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