Elucidation of Protein Structure and Processing Using Time-of-Flight Mass Spectrometry

  • Amina Woods
  • Rong Wang
  • Marc Chevrier
  • Tim Cornish
  • Cathy Wolkow
  • Robert J. Cotter
Chapter
Part of the Topics in Mass Spectrometry book series (STMS, volume 1)

Abstract

Traditionally, structural analysis by mass spectrometry has been limited to small organic molecules that are volatile and thermally stable, since the initial step involves heating the sample in a vacuum. During the past several years, new ionization methods have been developed that can produce gas-phase molecular and fragment ions from nonvolatile samples; these are presented to the mass spectrometer as liquids (solutions) or solids. As a consequence of these developments, mass spectrometry has come to play an increasing role in the biological sciences.

Keywords

Amyloid Precursor Protein Mass Resolution Rapid Comm Flight Tube Molecular Weight Measurement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Amina Woods
    • 1
  • Rong Wang
    • 1
  • Marc Chevrier
    • 1
  • Tim Cornish
    • 1
  • Cathy Wolkow
    • 1
  • Robert J. Cotter
    • 1
  1. 1.Middle Atlantic Mass Spectrometry Laboratory, Department of Pharmacology and Molecular SciencesThe Johns Hopkins University School of MedicineBaltimoreUSA

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