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Current Research on Hemoglobin Adducts and Cancer Risks: An Overview

  • Margareta Törnqvist
Chapter
Part of the NATO ASI Series book series (NSSA, volume 250)

Abstract

Most known chemical carcinogens are electrophilically reactive compounds (RX) or are formed in vivo from non-reactive precursors (A) (Miller and Miller, 1966). The electrophiles react with nucleophilic atoms (Y) of biomacromolecules giving rise to adducts (RY):
$$A \to RX\xrightarrow[{({k_y})}]{{ + {Y^ - }}}RY + {X^ - }$$
(1)
The measurement of adducts to sufficiently stable macromolecules may be used for identification of electrophiles in vivo and for dose monitoring as a basis for risk estimation. For reasons to be discussed below, the Stockholm group has used hemoglobin (Hb) for in vivo dose monitoring of chemical carcinogens in animals and humans.

Keywords

Cancer Risk Ethylene Oxide Environmental Tobacco Smoke Adduct Level Protein Adduct 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Margareta Törnqvist
    • 1
  1. 1.Department of RadiobiologyStockholm UniversityStockholmSweden

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