Advertisement

Key Features of Copper versus Molybdenum Metabolism Models in Humans

  • Judith R. TurnlundEmail author
  • Katherine H. Thompson
  • Karen C. Scott
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 445)

Abstract

Copper and molybdenum are essential nutrients for humans. Both trace elements are required in the diet in small amounts, are toxic in excess, and body stores are low. But there are major differences in their metabolism. Metabolic studies were conducted in the human nutrition suite of the Western Human Nutrition Research Center. Young men were confined to the unit for 2 to 90 days in studies of copper metabolism and for 120 days for studies of molybdenum metabolism. Stable isotopes were used as tracers to follow the metabolic fate of these elements. 65Cu was administered orally and intravenously in the copper studies. 100Mo was administered orally and 97Mo was administered intravenously in the molybdenum studies.

Keywords

Stable Isotope Thermal Ionization Mass Spectrometry Copper Deficiency Lysyl Oxidase Copper Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anonymous Trace Elements in Human Nutrition and Health. World Health Organization: Geneva. 1996. pp. 1-343.Google Scholar
  2. Abumrad NN. Molybdenum: Is it an essential trace metal? Bul NY Acad Med, 1984, 60:163–170.Google Scholar
  3. Abumrad NN; Schneider AJ; Steel D; Rogers LS. Amino acid intolerance during prolonged total parenteral nutrition reversed by molybdate therapy. Am J Clin Nutr, 1981, 34:2551–2559.Google Scholar
  4. Berman M; Beltz WF; Greif PC; Chabay R; Boston, RC. CONSAM User’s Guide. National Institutes of Health: Bethesda, MD. 1983.Google Scholar
  5. Buckley WT. A kinetic model of copper metabolism in lactating diary cows. Can J Anim Sci, 1991, 71:155–166.CrossRefGoogle Scholar
  6. Cantone MC; de Bartolo D; Gambarini G; Giussani A; Ottolenghi A; Pirola L. Proton activation analysis of stable isotopes for a molybdenum biokinetics study in humans. Med Phys, 1995, 22:1293–1298.CrossRefGoogle Scholar
  7. Cantone MC; de Bartolo D; Molho N; Priola L; Gambarine G; Hansen C; Roth P; Werner E. Response to a single oral test of molybdenum stable isotopes for absorption studies in humans. Physiol Meas, 1993, 14:217–225.CrossRefGoogle Scholar
  8. Cartwright GE; Wintrobe MM. The question of copper deficiency in man. Am J Clin Nutr, 1964, 14:94–110.Google Scholar
  9. Chiang G. Studies of Biochemical Markers Indicating Molybdenum Status in Human Subjects Fed Diets Varying in Molybdenum Content. Doctoral thesis, University of California, Los Angeles. 1991.Google Scholar
  10. Chiang G; Swendseid ME; Turnlund JR. Studies of biochemical markers indicating molybdenum (Mo) status in humans. FASEB J, 1989, 3:1073 (abs.).Google Scholar
  11. Crews HM; Dücros V; Eagles J; Mellon FA; Kastenmayer P; Luten JB; McGaw BA. Mass spectrometric methods for studying nutrient mineral and trace element absorption and metabolism in humans using stable isotopes. Analyst, 1994, 119:2491–2514.CrossRefGoogle Scholar
  12. Dunn MA. Historical overview of copper kinetics, in: Kinetic Models of Trace Element and Mineral Metabolism During Development. Subramanian KNS and Wastney ME; Eds. CRC Press: Boca Raton. 1995. pp. 171–185.Google Scholar
  13. Johnson JL. Molybdenum, in: Methods in Enzymology, Vol. 158. Riordan JF and Vallee BL; Eds. Academic Press: San Diego. 1988. pp. 371–382.Google Scholar
  14. Johnson JL; Waud WR; Rajagopalan KV; Duran M; Beemer FA; Wadman SK. Inborn errors of molybdenum metabolism: Combined deficiencies of sulfite oxidase and xanthine dehydrogenase in a patient lacking the molybdenum cofactor. Proc Natl Acad Sci, 1980, 77:3715–3719.CrossRefGoogle Scholar
  15. Johnson PE; Stuart MA; Hunt JR; Mullen L; Starks TL. 65Cu absorption by women fed intrinsically and extrinsically labeled goose meat, goose liver, peanut butter, and sunflower butter. J Nutr, 1988, 118:1522–1528.Google Scholar
  16. Levenson CW; Janghorbani M. Long-term measurement of organ copper turnover in rats by continuous feeding of a stable isotope. Anal Biochem, 1994, 221:243–249.CrossRefGoogle Scholar
  17. Mason KE. A conspectus of research on copper metabolism and requirements of man. J Nutr, 1979, 109:1979–2066.Google Scholar
  18. Mills CF; Davis GK. Molybdenum, in; Trace Elements in Human and Animal Nutrition, Mertz W; Ed. Academic Press: San Diego. 1987. pp. 429–463.Google Scholar
  19. National Research Council. Recommended Dietary Allowances; 9. National Academy of Sciences: Washington DC. 1980.Google Scholar
  20. National Research Council. Recommended Dietary Allowances; 10. National Academy Press: Washington, DC. 1989.Google Scholar
  21. Rajagopalan KV. Molybdenum: An essential trace element in human nutrition. Ann Rev Nutr, 1988, 8:401–427.CrossRefGoogle Scholar
  22. Rosoff B; Spencer H. The distribution and excretion of molybdenum-99 in mice. Health Physics, 1973, 25:173–175.Google Scholar
  23. Schroeder HA; Balassa JJ; Tipton IH. Essential trace metals in man: Molybdenum. J Chron Dis, 1970, 23:481–499.CrossRefGoogle Scholar
  24. Scott KC; Turnlund JR. Compartmental model of copper metabolism in adult men. J Nutr Biochem, 1994a, 5:342–350.CrossRefGoogle Scholar
  25. Scott KC; Turnlund JR. Compartmental model of zinc metabolism in adult men fed three levels of dietary copper. Am J Physiol, 1994b, 267:E165–E173.Google Scholar
  26. Thompson KH; Scott KC; Turnlund JR. Molybdenum metabolism in young men fed a range of intakes of molybdenum: Changes in kinetic parameters. J Appl Physiol, 1996, 81:1404–1409.Google Scholar
  27. Thompson KH; Turnlund JR. Kinetic model of molybdenum metabolism developed from dual stable isotope excretion in men consuming a low molybdenum diet. J Nutr, 1996, 126:963–972.Google Scholar
  28. Turnlund JR. Stable isotopes of copper, molybdenum, and zinc used simultaneously for kinetic studies of their metabolism, in: Kinetic Models of Trace Element and Mineral Metabolism During Development. Subramanian KNS; Wastney ME; Eds. CRC Press: Boca Raton. 1995. pp. 133–143.Google Scholar
  29. Turnlund JR. Copper, in: Modern Nutrition in Health and Disease. Shils ME; Olson JA; Shike M; Oss AC; Eds. Williams & Wilkins: Baltimore. 1998.Google Scholar
  30. Turnlund JR; Keen CL;. Smith RG. Copper status and urinary and salivary copper in young men at three levels of dietary copper. Am J Clin Nutr, 1990, 51:658–664.Google Scholar
  31. Turnlund JR; Keyes WR. Automated analysis of stable isotopes of zinc, copper, iron, calcium, and magnesium by thermal ionization mass spectrometry using double isotope dilution for tracer studies in humans. J Micronutrient Analysis, 1990, 7:117–145.Google Scholar
  32. Turnlund JR; Keyes WR; Anderson HL; Acord LL. Copper absorption and retention in young men at three levels of dietary copper by use of the stable isotope 65Cu. Am J Clin Nutr, 1989, 49:870–878.Google Scholar
  33. Turnlund JR; Keyes WR; Peiffer GL. Copper absorption and retention from diets low and adequate in copper. Am J Clin Nutr, 1995a, 61:908 (abs.).Google Scholar
  34. Turnlund JR; Keyes WR; Peiffer GL. Copper excretion into the gastrointestinal tract at three levels of dietary copper studied with the stable isotope 65Cu. FASEB J, 1995b, 9:A725 (abs.).Google Scholar
  35. Turnlund JR; Keyes WR; Peiffer GL. Molybdenum absorption, excretion, and retention studied with stable isotopes in young men at five intakes of dietary molybdenum. Am J Clin Nutr, 1995c, 62:790–796.Google Scholar
  36. Turnlund JR; Keyes WR; Peiffer GL; Chiang G. Molybdenum absorption, excretion, and retention studied with stable isotopes in young men during depletion and repletion. Am J Clin Nutr, 1995, 61:1102–1109.Google Scholar
  37. Turnlund JR; Scott KC; Peiffer GL; Jang AM., Keen CL; Sakanashi TM. Copper status of young men consuming a low copper diet. Am J Clin Nutr, 1997, 65:72–78.Google Scholar
  38. Turnlund JR; Weaver CM; Kim SK; Keyes WR; Peiffer GL. Absorption and utilization of molybdenum from soy, kale and an extrinsic label. FASEB J, 1996, A818 (abs.).Google Scholar
  39. Weber KM; Boston RC; Leaver DD. A kinetic model of copper metabolism in sheep. Aust J Agric Res, 1980, 31:773–790.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Judith R. Turnlund
    • 1
    Email author
  • Katherine H. Thompson
    • 2
  • Karen C. Scott
    • 3
  1. 1.USDA/ARSWestern Human Nutrition Research CenterPresidio of San FranciscoUSA
  2. 2.Chemistry DepartmentThe University of British ColumbiaVancouverCanada
  3. 3.Department of Small Animal Clinical SciencesUniversity of FloridaGainesvilleUSA

Personalised recommendations