Mechanism of Anti-Proliferative Action of Eicosapentaenoic Acid (EPA) in Vascular Cell Growth: Its Effect on Signal Transduction System
In late 1970s, Dyerberg and Bang reported that a low incidence of cardiovascular thrombotic disorders could be ascribed to a large intake of marine diet rich in ω-3 polyunsaturated fatty acids (PUFA)1. Since then epidemiological, nutritional and pharmacological studies related to ω-3 PUFA have been performed by numerous investigators. We have been performed clinical and basic studies about the mechanism of action of EPA, using a highly purified EPA (EPA-ethylester: EPA-E, over 95%) from sardine oil. Here we want to present our research results about the mechanism of anti-atherogenic and anti-thrombotic action of EPA, especially emphasizing on the mechanism of its anti-proliferative action.
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