The Role of Retinoids in Developmental Mechanisms in Embryos

  • Malcolm Maden
Chapter
Part of the Subcellular Biochemistry book series (SCBI, volume 30)

Abstract

It has been known since the 1920s that the appropriate level of vitamin A (retinoids) in the maternal diet is vital for the development of the embryo (Kalter and Warkany, 1959). Both too little or too much vitamin A results in characteristic defects appearing in the embryo: defects in the central nervous system, various structures of the head and neck, the heart, the limb, and the urogenital system. These studies thus revealed that excess vitamin A was teratogenic and harmful to embryos and the usual interpretation of its effects was that it was causing cell death or an inhibition of development.

Keywords

Retinoic Acid Retinoic Acid Receptor Retinyl Palmitate Blastemal Cell Chick Limb 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Malcolm Maden
    • 1
  1. 1.Developmental Biology Research CentreKing’s College LondonLondonEngland

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