Advertisement

Why do Some Parasitic Nematodes Secrete Acetylcholinesterase (ACHE)?

  • David. I. Pritchard
  • Chris Jagger
  • Chris Green
  • Ken Lowe

Abstract

While the expression and secretion of AChE by some parasitic nematodes is well documented (figure 1), the true biological significance(s) of this process remains speculative. Parasite-protective/beneficial roles have been suggested (1), for the following reasons. AChE has the potential to:
  1. i.

    modulate intestinal peristalsis, by destroying host acetylcholine (ACh), thus providing the parasite with a biochemical holdfast. (AChE may not, in fact, be involved (10) in this process.).

     

Keywords

Parasitic Nematode Chronic Nicotine Intestinal Peristalsis Chronic Nicotine Treatment Peripheral Blood Lympho 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Pritchard, DI (1993) Why do some parasitic nematodes secrete acetylcholinesterase (AChE). International Journal for Parasitology 23, 549–550.PubMedCrossRefGoogle Scholar
  2. 2.
    Bronzetti, E et al. (1996) Muscarinic cholinergic receptor subtypes in human peripheral blood lymphocytes. Neuroscience Letters 208, 211–215.PubMedCrossRefGoogle Scholar
  3. 3.
    Fujino, H et al. (1997) Stimulatory roles of muscarinic acetylcholine receptors on T cell antigen receptor/CD3 complex-mediated interleukin-2 production in human peripheral blood lymphocytes. Molecular Pharmacology 51, 1007–1014.PubMedGoogle Scholar
  4. 4.
    Griffiths, G and Pritchard, DI (1994) Purification and biochemical characterization of acetylcholinesterase (AChE) from the excretory/secretory products of Trichostrongylus colubriformis. Parasitology 108, 579–586.PubMedCrossRefGoogle Scholar
  5. 5.
    Camacho, M; Alsford, S; Jones, A; Agnew, A (1995) Nicotinic acetylcholine receptors on the surface of the blood fluke Schistomsoma. Molecular and Biochemical Parasitology 71, 127–134.PubMedCrossRefGoogle Scholar
  6. 6.
    Qiu, Y; Peng, Y and Wang J (1996) Immunoregulatory role of neutrotransmitters. Advances in Neuroimmunology 6, 223–231.PubMedCrossRefGoogle Scholar
  7. 7.
    Chandra, R K and Madhavankutty K (1975) Effect of cholinesterase inhibition by eserine and phospholipase D on human T lymphocyte rosetting. Experimentia 31/7, 858–859.Google Scholar
  8. 8.
    Rinner, I and Schauenstein K (1993) Detection of choline-acetyltransferase activity in lymphocytes. Journal of Neuroscience Research 35, 188–191.PubMedCrossRefGoogle Scholar
  9. 9.
    Geng, Y; Savage, SM; Razani-Boroujerdi, S and Spori MH (1996) Effects of nicotine on the immune response, II Chronic nicotine treatment induces T cell anergy. The Journal of Immunology 156, 2384–2390.PubMedGoogle Scholar
  10. 10.
    Foster, N; Dean, EJ and Lee, DL (1993) The effect of homogenates and excretory/secretory products of Nippostrongylus brasiliensis and of acetylcholinesterase on the amplitude and frequency of contraction of uninfected rat intestine in vitro. Parasitology 108, 453–459.CrossRefGoogle Scholar
  11. 11.
    Blackburn, CC and Selkirk, ME (1992) Characterisation of the secretory acetylcholinesterases from adult Nippostrongylus brasiliensis. Molecular and Biochemical Parasitology 53, 79–88.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • David. I. Pritchard
    • 1
  • Chris Jagger
    • 1
  • Chris Green
    • 1
  • Ken Lowe
    • 1
  1. 1.School of Biological SciencesUniversity of NottinghamNottinghamEngland

Personalised recommendations