The Role of the Myofibroblast in Wound Healing and Fibrocontractive Diseases

  • Alexis Desmoulière
  • Giulio Gabbiani


Following tissue injury, tissue repair takes place in well-characterized steps. After clot formation, inflammatory cells, essentially mononuclear cells and granulocytes, invade the injured tissue; then, fibroblasts migrate, proliferate, and synthesize extracellular matrix components, participating in the formation of granulation tissue. Finally, following reepithelialization and wound closure, tissue remodeling implicates extracellular matrix degradation, decrease of cellularity, and constitution of the scar.


Wound Healing Granulation Tissue Myosin Heavy Chain Connective Tissue Growth Factor Extracellular Matrix Component 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Alexis Desmoulière
    • 1
    • 2
  • Giulio Gabbiani
    • 3
  1. 1.Department of PathologyUniversity of GenevaSwitzerland
  2. 2.Institut Pasteur de LyonCNRS-URA 1459Lyon cedex 7France
  3. 3.Department of PathologyUniversity of GenevaGeneva 4Switzerland

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