Taurine 2 pp 385-391 | Cite as

Sodium- and Chloride-Dependent Transport of Taurine at the Blood-Brain Barrier

  • Akira Tsuji
  • Ikumi Tamai
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)


Sodium- and Cl--dependent taurine transports have been clarified in kidney12 and intestine2. However, there has been only one report, in 1989, for taurine transport at the blood-brain barrier (BBB). This study, using isolated brain capillaries, showed the existence of a Na+-dependent high-affinity uptake system for taurine with a Kt value of about 30 μM at the abluminal membrane4. However, the polarity of taurine transport is difficult to establish with this classical isolated brain capillary technique, because overall uptake may include both luminal and abluminal components.


Brain Capillary Endothelial Cell Taurine Transport Sodium Gluconate Taurine Uptake Potassium Gluconate 
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  1. 1.
    Audus, K.L. and Borchardt, R.T. 1986, Characteristics of the large neutral amino acid transport system of bovine brain microvessel-endothelial cell monolayers, J.Neurochem. 47:484–488.CrossRefGoogle Scholar
  2. 2.
    Miyamoto, Y., Tiruppathi, C., Ganapathy, V., and Leibach, F.H. 1989, Active transport of taurine in rabbit jejunal brush-border membrane vesicles, Am.J.Physiol. 257:G65–G72.Google Scholar
  3. 3.
    Tamai, I., Senmaru, M., Terasaki, T., and Tsuji, A. 1995, Na+ and CL--dependent transport of taurine at the blood-brain barrier, Biochem.Pharmacol. 50:1783–1793.CrossRefGoogle Scholar
  4. 4.
    Tayarani, I., Cloëz, I., Lefauconnier, J.-M., and Bourre, J.-M. 1989, Sodium-dependent high-affinity uptake of taurine by isolated rat brain capillaries, Biochim.Biophys.Acta, 985:168–172.CrossRefGoogle Scholar
  5. 5.
    Terasaki, T., Takakuwa, S., Moritani, S., and Tsuji, A. 1991, Transport of monocarboxylic acids at the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells, J.Pharmacol.Exp.Ther. 258:932–937.Google Scholar
  6. 6.
    Terasaki, T., Takakuwa, S., Saheki, A., Moritani, S., Shimura, T., Tabata, S., and Tsuji, A. 1992, Absorptive-mediated endocytosis of an adrenocorticotropic hormone (ATCH) analogue, ebiratide, into the blood-brain barrier: studies with monlaters of primary cultured bovine brain capillary endothelial cells, Pharm.Res. 9:529–534.CrossRefGoogle Scholar
  7. 7.
    Törnquist, P. and Alm, A. 1986, Carrier-mediated tranport of amino acids through the blood-retinal and blood-brain barrier, Graefe’s Arch.Clin.Exp.Ophthalmol. 224:21–25.CrossRefGoogle Scholar
  8. 8.
    Tossman, U., Wieloch, T., and Ungerstedt, U. 1985, Gamma-aminobutyric acid and taurine release in the striatum of the rat during hypoglycemic coma, studied by microdialysis, Neuroscience Letters, 62:231–236.CrossRefGoogle Scholar
  9. 9.
    Tsuji, A., Saheki, A., Tamai, I., and Terasaki, T. 1993, Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier, J.Pharmacol.Exp. Ther. 261:1085–1090.Google Scholar
  10. 10.
    Tsuji, A., Tamai, I., Sakata, A., Tenda, Y., and Terasaki, T. 1993, Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein, Biochem.Pharmacol. 46:1096–1099.CrossRefGoogle Scholar
  11. 11.
    Tsuji, A., Terasaki, T., Takabatake, Y., Tenda, T., Tamai, I., Yamashima, T., Moritani, S., Tsuruo, T., and Yamashita, J. 1992, P-Glycoprotein as the durg efflux pump in primary cultured bovine brain capillary endothelial cells, Life Sci. 51:1427–1437.CrossRefGoogle Scholar
  12. 12.
    Zelikovic, I., Stejskal-Lorenz, E., Lohstroh, P., Budreau, A., and Chesney, R.W. 1989, Anion dependence of taurine transport by rat renal brush-border membrane vesicles, Am.J.Physiol. 256:F646–F655.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Akira Tsuji
    • 1
  • Ikumi Tamai
    • 1
  1. 1.Faculty of Pharmaceutical SciencesKanazawa UniversityKanazawaJapan

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