Effects of 5-HT and GABA agents on aggressive responding of adult men with a history of childhood conduct disorder

  • Don R. Cherek
  • Scott D. Lane
Chapter

Abstract

Numerous studies in nonhumans and human subjects have supported a role for serotonin (5-HT) in aggression. Reduced levels of 5-HT in cerebrospinal fluid (CSF) have been associated with increased likelihood of aggression in free-ranging monkeys1–4 and human adult males5–6 as well as children7. Decreased 5-HT activity determined by neuroendocrine challenge procedures has recorded blunted responses, i.e., diminished activity, in human subjects with a history of aggression8–10.

Keywords

Medication Event Monitoring System Tryptophan Depletion Response Panel Human Aggression Childhood Conduct Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Don R. Cherek
    • 1
  • Scott D. Lane
    • 1
  1. 1.Human Psychopharmacology Laboratory, Department of Psychiatry and Behavioral Sciences, Mental Sciences InstituteUniversity of Texas Health Science Center at HoustonHoustonUSA

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