Biochemical Studies on the Muscarinic Acetylcholine Receptor

  • T. Haga
  • G. Berstein
  • T. Nishiyama
  • H. Uchiyama
  • K. Ohara
  • K. Haga
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 236)

Abstract

The muscarinic acetylcholine receptor was functionally defined, based on the actions of specific drugs on specific cells or tissues (for a review, see ref. 1). The development of specific radio-labeled ligands (2,3) enabled us to estimate and characterize the ligand-binding sites independently of their functions. Quantitative analysis of the binding of specific ligands with membrane preparations allowed to define at least three different subtypes of muscarinic receptors (4,5), and the regional distribution of these subtypes was also determined (6,7). Although different kinds of actions are known to be elicited by muscarinic agonists depending on species of cells or tissues, the relation between the subtypes and the actions elicited by their activation is not straightforward so far (for example, see ref. 8).

Keywords

Muscarinic Receptor Atrial Receptor Guanine Nucleotide Muscarinic Acetylcholine Receptor Muscarinic Agonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • T. Haga
    • 1
  • G. Berstein
    • 1
  • T. Nishiyama
    • 2
  • H. Uchiyama
    • 1
  • K. Ohara
    • 1
  • K. Haga
    • 1
  1. 1.Department of BiochemistryHamamatsu University School of MedicineHamamatsuJapan
  2. 2.Internal MedicineHamamatsu University School of MedicineHamamatsuJapan

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