Regulation of the Glial Fibrillary Acidic Protein (GFAP) and of its Encoding mRNA in the Developing Brain and in Cultured Astrocytes
The Glial Fibrillary Acidic Proctein (GFAP) is the monomer of a well characterized type of intermediary filaments, the fliofilaments, structurally identified as 10nm in diameter and which are essential components of the cytoskeletal architecture of the astrocyte (see Eng 1980 for a review). The expression of GFAP has been found to be highly specific of this cell type (Eng et al. 1971; Bignami et al. 1972; Uyeda et al. 1972; Gilden et al.1976: Ludwin et al. 1976; Ludwin et al. 1976; Lach and Weinmander 1978) and may therefore be used as an exclusive marker of astroglial cells.
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