Idiopathic Interstitial Fibrosis

  • Samuel P. Hammar


Fibrosis is a nonspecific reaction to injury typically occurring in association with or after a significant inflammatory process. In the case of a myocardial infarct, for example, the region of ischemic necrosis is eventually replaced by a dense fibrous scar. In skin, regions of surgical incision or traumatic laceration undergo fibrosis as part of the normal healing process. Similarly, the lung is an organ in which fibrotic reactions occur. In some instances, such as pulmonary infarcts, fibrosis may be part of a normal healing process and the mechanism of fibrosis is relatively well understood. In other conditions, such as asbestosis, the etiology is apparent but the mechanism of fibrosis is poorly understood. In myocardial infarcts and wound healing, fibrosis serves a useful purpose. When it occurs in the interstitium of peripheral lung tissue, it has a deleterious effect, interfering with normal physiologic functions such as blood flow and gas diffusion.


Idiopathic Pulmonary Fibrosis Pulmonary Fibrosis Interstitial Lung Disease Interstitial Fibrosis Interstitial Pneumonitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1988

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  • Samuel P. Hammar

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