Abstract
Delusional disorder is characterized by mono-symptomatic paranoid symptoms without other schizophrenic symptoms. Thus, delusional disorder can be a good clinical model for investigating the molecular genetic mechanisms for paranoid symptoms. In this study, we hypothesized that a hyperdopaminergic state in the brain is responsible for producing paranoid symptoms. To test this hypothesis, we (1) compared neuroleptic responses between patients with delusional disorder and schizophrenia, (2) measured plasma levels of homovanillic acid (pHVA), an indicator of brain dopamine activity, in patients with delusional disorder, and (3) analysed the polymorphism of dopamine receptors (DRs) and its synthesizing enzyme gene.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Garver DL, Steinberg JL, McDermott BE, et al: Etiologic heterogeneity of the psychoses: is there a dopamine psychosis? Neuropsychopharmacol 14:191–201, 1997.
Arinami T, Itokawa M, Enguchi H, et al: Association of dopamine D2 receptor molecular variant with schizophrenia. Lancet 343:703–704, 1994.
Arinami T, Itokawa M, Aoki J, et al: Further association study on dopamine D2 receptor variant S311C in schizophrenia and affective disorder. Am J Med Genet 67:133–138, 1996.
Serretti A, Latuada E, Lorenzi R, et al: Dopamine receptor D2 Ser/Cys311 is associated with delusion and disorganization symptomatology in major psychoses. Mol Psychiatry 5:270–274, 2000.
Crocq MA, Mant R, Asherson P, et al: Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. J Med Genet 29:858–860, 1992.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Morimoto, K., Miyatake, R., Nakamura, M. (2002). Dopamine Psychosis in Schizophrenia? Molecular Genetic Study on Delusional Disorder. In: Nagatsu, T., Nabeshima, T., McCarty, R., Goldstein, D.S. (eds) Catecholamine Research. Advances in Behavioral Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3538-3_98
Download citation
DOI: https://doi.org/10.1007/978-1-4757-3538-3_98
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-3388-1
Online ISBN: 978-1-4757-3538-3
eBook Packages: Springer Book Archive