Proton Transfer Reactions

  • Daniel Borgis
  • James T. Hynes
Chapter
Part of the Progress in Mathematics book series (NSSA)

Abstract

Proton (H+) transfers play a central role in many enzymatic reactions.1 A good illustration is provided by serine protease reactions.2–4 In a recent theoretical study4 of the serine protease tripsin-catalyzed hydrolysis of a specific tripeptide substrate, there are no less than four proton transfer steps, beginning with a serine to histidine H+ transfer in the Michaelis complex (Fig. 1) Another example is furnished in a study5, 6 of the reversible isomerization of dihydroxyacetone (DHAP) to glyceraldehyde 3-phosphate (GAP) by the enzyme triose phosphate isomerase (TIM). A key step in the DHAP ⇌ GAP reaction is the proton abstraction by a carboxylate group in Glu 165 of a CH proton in DHAP (Fig. 2).

Keywords

Barrier Height Proton Transfer Proton Transfer Reaction Transition State Theory Kinetic Isotope Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Daniel Borgis
    • 1
  • James T. Hynes
    • 1
  1. 1.Department of Chemistry and BiochemistryUniversity of ColoradoBoulderUSA

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