Evidence for a Urate Reabsorptive Defect in Patients with Wilson’s Disease

  • D. M. Wilson
  • N. P. Goldstein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41)


Most patients with Wilson’s disease have hypouricemia. The urate pool is diminished and the clearance of urate is increased two to three times normal. Leu (1) suggested that serum urate returns to normal after treatment with D-penicillamine, but some of our patients had continued hypouricemia after many years of treatment. This prompted us to review urate excretion in a group of patients both before and after drug therapy.


Fractional Excretion Serum Urate Phosphate Reabsorption Urate Transport Urate Excretion 
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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • D. M. Wilson
    • 1
  • N. P. Goldstein
    • 1
  1. 1.Mayo Clinic and Mayo FoundationRochesterUSA

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