The Clinical Significance of Hypouricemia

  • C. M. Ramsdell
  • W. N. Kelley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41)


The development of automated techniques in the clinical laboratory which routinely include the measurement of uric acid has raised important questions concerning the clinical significance of abnormal serum urate values. Although numerous studies have focused on the relevance of hyperuricemia, the possible significance of hypouricemia has not been investigated. Hypouricemia has been reported as a manifestation of a number of relatively rare diseases including xanthinuria, Fanconi’s syndrome due to any cause, acute intermittent porphyria and an isolated renal defect in transport of uric acid. In addition, many drugs can lower the serum urate concentration and could potentially lead to the development of hypouricemia. The reported and potential causes of hypouricemia are summarized in Table 1. The purpose of the present prospective investigation was to determine the etiology, pathogenesis and clinical significance of hypouricemia in hospitalized patients.


Neoplastic Disease Pernicious Anemia Glycogen Storage Disease Serum Urate Acute Intermittent Porphyria 
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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • C. M. Ramsdell
    • 1
  • W. N. Kelley
    • 1
  1. 1.Department of MedicineDuke University Medical CenterDurhamUSA

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