The Synthesis and Immuno-Enhancing Activity of 3-Butylazathioprine

  • A. H. Chalmers
  • A. W. Murray
  • P. Verakalasa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41)


As part of a programme of the design and testing of potential immunosuppressive and anticancer drugs, 9-butylazathioprine was synthesised (Chalmers, Knight & Atkinson, 1969) and shown to be an immunosuppressive agent (Chalmers, Gotjamanos, Rao, Knight & Atkinson, 1971; Chalmers, Burdorf & Murray, 1972). During the chemical synthesis of this compound from azathioprine and 1-iodobutane (Chalmers et al., 1969) small amounts of the 3-isomer (3-butylazathioprine) were formed. This paper describes the isolation and characterisation of this compound and reports the ability of the analogue to enhance the antibody response of mice to sheep red blood cells.


Antibody Response Spleen Cell Antigenic Challenge Swiss Albino Mouse Deuterated Chloroform 
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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • A. H. Chalmers
    • 1
  • A. W. Murray
    • 1
  • P. Verakalasa
    • 1
  1. 1.School of Biological SciencesFlinders University of South AustraliaBedford ParkAustralia

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