Influence of a Uricosuric Drug on Connective Tissue Metabolism

  • H. Greiling
  • M. Kaneko
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41)


Benzbromaron acts as an uricosuric substance, but there is a quantitative discrepancy between uric acid excretion and the depression of uric acid level in blood serum. In figure 1 you see that there is an increased excretion of uric acid but there remains an amount of uric acid, which is not due to the increased uric acid excretion. Benzbromaron is in vitro a xanthineoxydase inhibitor, but as you see from these experiments there is no decrease in oxypurine excretion after benzbromaron application.


Uric Acid Synovial Fluid Chondroitin Sulfate Lysosomal Enzyme Joint Cartilage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Müller, M.M., and W. Bresnik, Klin. Wschr. 50, 1015 (1972)CrossRefGoogle Scholar
  2. 2.
    Whitehouse, M.W., in Progress in Drug Research, Vol. 8, 320, Birkhäuser Verlag Basel und Stuttgart (1965)Google Scholar
  3. 3.
    Momburg, M., H.W. Stuhlsatz, R. Kisters and H. Greiling, Hoppe-Seyler’s Z. physiol. Chem. 353, 1351 (1972)CrossRefGoogle Scholar
  4. 4.
    Greiling, H., Th. Herbertz, B. Schuler and H.W. Stuhlsatz, Z. Rheumaforsch. 21, 50 (1962)Google Scholar
  5. 5.
    Katz, W.A. and M. Schubert, J. Clin. Invest. 49, 1783 (1970)CrossRefGoogle Scholar
  6. 6.
    Greiling, H. in Connective Tissue and Ageing, S. 168, Excerpta Medica Amsterdam (1973)Google Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • H. Greiling
    • 1
  • M. Kaneko
    • 1
  1. 1.Klinisch-chemisches ZentrallaboratoriumRheinisch-Westfälischen Techn. HochschuleAachenGermany

Personalised recommendations