Experimental Hyperuricemia in Rats
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Renal Disease is a well recognized complication of gout, and the typical histologic features of chronic gouty nephropathy have been carefully studied, however, early evolution of the nephropathy and its precise relationship to hyperuricemia and uricosuria have been difficult to study in the human subject. Unfortunately, animal models of sustained hyperuricemia are difficult to produce and maintain. Recently, Stavric and colleagues described the production of hyperuricemia and urate nephropathy in rats fed orally with oxonic acid and uric acid. oxonic acid is a potent, hepatic uricase inhibitor; and this chemical, combined with uric acid or RNA dietry supplements, consistently leads to hyperuricemia in this species.
KeywordsUric Acid Solubilised Tissue Individual Metabolic Cage Plasma Urate Urate Deposition
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