Metabolic and Glucose Load Studies in Uric Acid, Oxalic and Hyperparathyroid Stone Formers
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There is as yet little knowledge about the metabolic origin of idiopathic hypercalciuria (HC) and associated hyperuricosuria frequently accompanied by formation of calcium containing renal stones. Following a carbohydrate-rich meal, in 1969 Lemann and coworkers (1) observed higher urinary calcium in oxalic stone formers and their relatives than in healthy controls. Endogenous resistance to insulin and its consecutive overproduction was recently reported from patients with primary hyperparathyroidism (2), and a marked loss of insulin via urine was objectived by Ching and his group (3) in patients producing calcium stones. They failed to find disturbed glucose tolerance, but their data gave no information as to the amount of glucose administered. In earlier studies (unpublished) undertaken to screen stone people by oral glucose load (100g) we found pathological plasma glucose (2 hours) in a rather great number of stone patients without symptoms of diabetes and /or overt obesity. Also there was apparently no relation to either sex or age or, most important, the type of stone, i.e. oxalic or uric acid.
KeywordsUric Acid Primary Hyperparathyroidism Glucose Load Renal Stone Calcium Oxalate
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