Dietary Fiber, Bile Acids and Cholesterol Metabolism

  • G. V. Vahouny
Chapter
Part of the Nutrition and Food Science book series (NFS, volume 3)

Abstract

There is considerable evidence that high dietary fiber intake is associated with a reduced incidence of ischemic heart disease in humans1, 4 and a reduced rate of atheroma development in laboratory animals5, 7. Experimental approaches to elucidate the underlying mechanisms of these effects have yielded inconsistent results both with natural fiber, such as wheat bran, and with purified fiber components like cellulose4, 7. This has been due, in part, to the criteria employed to determine the physiological response to changing fiber content of the diet, and in part, to the composition of the diets themselves. In some cases, the determination of serum of liver cholesterol levels, for example, has not permitted definitive conclusions regarding the overall effects of dietary fiber, since in the human, and in experimental animals like the rat, there are efficient homeostatic mechanisms for regulating circulating sterol levels.

Keywords

Bile Acid Bile Salt Dietary Fiber Cholesterol Absorption Wheat Bran 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Trowell, H., Ischemic heart disease and dietary fiber. Am. J. Clin. Nut. 25: 926, 1972.Google Scholar
  2. 2.
    Trowell, H., Dietary fiber and coronary heart disease. Eur. J. Clin. Biol. Res. 17: 345, 1972.Google Scholar
  3. 3.
    Burkitt, D.P., A.R.P. Walker and N.S. Painter. Dietary fiber and disease. J. Am. Med. Assn. 229: 1068, 1974.CrossRefGoogle Scholar
  4. 4.
    Kay, R.M. and S.M. Strasberg. Origin, chemistry, physiological effects and clinical importance of dietary fibers. Clin. Invest. Med. 1: 9, 1978.Google Scholar
  5. 5.
    Kritchevsky, D., S.A. Tepper, D.E. Williams and J.A. Story. Experimental atherosclerosis in rabbits fed cholesterol-free diets. Part 7. Interaction of animal or vegetable protein with fiber. Atherosclerosis. 26: 397, 1977.CrossRefGoogle Scholar
  6. 6.
    Moore, J.H., The effect of the type of roughage in the diet on plasma cholesterol level and aortic atherosclerosis in rabbits. Brit. J. Nutr. 21: 207, 1967.CrossRefGoogle Scholar
  7. 7.
    Kritchevsky, D., Effect of dietary fiber on lipid metabolism and atherosclerosis. In: “International Conference on Atherosclerosis”. L. Carlson, R. Paoletti and G. Weber, eds. Raven Press, New York, 1978, p. 169.Google Scholar
  8. 8.
    Eastwoo, M.A. and D. Hamilton. Studies on the adsorption of bile salts to non-absorbed components of the diet. Biochim. Biophys. Acta 152: 165, 1968.CrossRefGoogle Scholar
  9. 9.
    Kritchevsky, D. and J.A. Story. Binding of bile salts in vitro to nonnutritive fibers. J. Nutr. 104: 458, 1974.Google Scholar
  10. 10.
    Story, J.A. and D. Kritchevsky. Binding of sodium taurocholate by various foodstuffs. Nutr. Rep. Int. 11: 161, 1975.Google Scholar
  11. 11.
    Story, J.A. and D. Kritchevsky. Comparison of the binding of various bile acids and bile salts in vitro by several types of fiber. J. Nutr. 106: 1292, 1976.Google Scholar
  12. 12.
    Kritchevsky, D., S.A. Tepper and J.A. Story. Isocaloric, isogravic diets in rats. III. Effects of non-nutritive fiber (alfalfa or cellulose) on cholesterol metabolism. Nutr. Rep. Int. 9: 301, 1974.Google Scholar
  13. 13.
    Levelle, G.A. and H.E. Sauberlich. Mechanism of the cholesterol depressing effect of pectin in the cholesterol fed rat. J. Nutr. 88: 207, 1966.Google Scholar
  14. 14.
    Story, J.A., S.K. Czarnecki, A. Baldino and K. Kritchevsky. Effect of components of fiber on dietary cholesterol in the rat. Fed. Proc. 36: 1134, 1977.Google Scholar
  15. 15.
    Vahouny, G.V., T. Roy, L.L. Gallo, J.A. Story, D. Kritchevsky, M. Cassidy, B. Grund and C.R. Treadwell. Dietary fiber and lymphatic absorption of cholesterol in the rat. Am. J. Clin. Nutr. 31: 208, 1978.Google Scholar
  16. 16.
    Kritchevsky, D., Fiber, lipids and atherosclerosis. Am. J. Clin. Nut. 31: 65, 1978.Google Scholar
  17. 17.
    Cookson, F.B., R. Altschul and S. Fedoroff. The effects of alfalfa on serum cholesterol and in modifying or preventing cholesterol-induced atherosclerosis in rabbits. J. Athero. Res. 7: 69, 1967.CrossRefGoogle Scholar
  18. 18.
    Kritchevsky, D., R.P. Casey and S.A. Tepper. Isocaloric, isogravic diets it rats. II. Effect on cholesterol absorption and excretion. Nutr. Rep. Int. 7: 61, 1973.Google Scholar
  19. 19.
    Kelly, J.J. and A.C. Tsai. Effect of pectin, gum arabic and agar on cholesterol absorption, synthesis and turnover in rats. J. Nutr. 108: 630, 1978.Google Scholar
  20. 20.
    Hyun, S.A., G.V. Vahouny and C.R. Treadwell. Effect of hypocholesteremic agent on intestinal cholesterol absorption. Proc. Soc. Exp. Biol. Med. 112: 496, 1963.CrossRefGoogle Scholar
  21. 21.
    Zilversmit, D.B., A single blood sample dual isotope method for the measurement of cholesterol absorption in rats. Proc. Soc. Exp. Biol. Med. 140: 862, 1972.CrossRefGoogle Scholar
  22. 22.
    Vahouny, G.V., M. Ito, E.B. Blendermann and C.R. Treadwell. Puromycin inhibition of cholesterol absorption in the rat. J. Lipid Res. 18: 745, 1977.Google Scholar
  23. 23.
    Hagerman, L.M., D.A. Julow,and D.L. Schneider. In vitro binding of mixed micellar solutions of fatty acids and bile salts by cholestyramine. Proc. Soc. Exp. Biol. Med. 143: 89, 1973.CrossRefGoogle Scholar
  24. 24.
    Thornton, A., G.V. Vahouny and C.R. Treadwell. Absorption of lipids from mixed micellar bile salt solutions. Proc. Soc. Exp. Biol. Med. 127: 629, 1968.CrossRefGoogle Scholar
  25. 25.
    Treadwell, C.R. and G.V. Vahouny. Cholesterol absorption. In: “Handbook of Physiology, Alimentary Canal”. American Physiological Society, Washington, D.C., 1968, p. 1407.Google Scholar
  26. 26.
    Robbins, E.A. and R.D. Seeley. Cholesterol lowering effect of dietary yeast and yeast fractions. J. Food Sci. 42: 694, 1977.CrossRefGoogle Scholar
  27. 27.
    Nicolau, G., S. Shefer, G. Salen and E.H. Mosbach. Determination of hepatic cholestegol 7α-hydroxylase activity in man. J. Lipid Res. 15: 146, 1974.Google Scholar
  28. 28.
    Kritchevsky, D., S.A. Tepper and J.A. Story. Nonnutritive fiber and lipid metabolism. J. Food Sci. 40: 8, 1975.CrossRefGoogle Scholar
  29. 29.
    Cassidy, M.M., B. Grund, F. Lightfoot, G.V. Vahouny, L.L. Gallo, D. Kritchevsky, J. Story and C.R. Treadwell. Alterations in topographical ultrastructure of rat jejunum and colon induced by feeding with alfalfa and cholestyramine. Fed. Proc. 37: 543, 1978.Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • G. V. Vahouny
    • 1
  1. 1.Dept. of BiochemistryThe George Washington UniversityUSA

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