Evolution of a Coronavirus during Persistent Infection inVitro

  • Kathryn V. Holmes
  • James N. Behnke
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 142)


Coronaviruses usually infect epithelial cells of the gastro-enteric or respiratory tracts. They frequently cause local infections which may be fatal in young animals, but which are usually mild or asymptomatic in adults. In vitro, coronaviruses may induce virulent, cytolytic and cell fusing effects in some host cells but cause a moderate, persistent infection in other cell types. Thus the host or the host cell appears to be of critical importance in determining the outcome of coronavirus infection. This report will focus on the role of the host cell in coronavirus replication and on the mutually dependent changes induced in the host cell and the virus during the establishment of a persistent infection in vitro.


Rough Endoplasmic Reticulum Persistent Infection Infectious Bronchitis Virus Wild Type Virus Mouse Hepatitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Kathryn V. Holmes
    • 1
  • James N. Behnke
    • 1
  1. 1.Pathology Dept., Uniformed ServicesUniversity of the Health SciencesBethesdaUSA

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