In Vivo and in Vitro Models of Demyelinating Diseases

  • Ole Sorensen
  • Marion Coulter-Mackie
  • Dean Percy
  • Samuel Dales
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 142)


One feature characterizing chronic viral infections of the nervous system (NS) associated with progressive degenerative disease is the capacity of the viral agent to maintain itself in a persistent, and/or latent state for prolonged periods. Ability of DNA viruses of the herpes or papova type to remain covert intermittently or for indefinite periods within nuclei of neurons, particularly in peripheral nerve ganglia, has been clearly documented (1–4). RNA viruses of the retrotype such as Visna and C-type of wild mice which, via a provirus intermediate, can become integrated into the host’s genome, likewise possess the potential for maintaining persistent or latent infections in the NS (5, 6). It is, however, puzzling how neurotropic RNA agents, among them coronaviruses with +RNA genomes and paramyxoviruses with -RNA genomes, may be perpetuated in the same manner as the viruses mentioned above. As part of our continuing programme of investigations of mechanisms by which NS diseases are produced by some RNA viruses we have studied on the one hand the pathological process in the central nervous system (CNS) of rodents and on the other cell-virus interactions in selected lines of rodent cells of neural and other derivation.


Optic Nerve Optic Neuritis White Matter Lesion Measle Virus DEMYELINATING Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Ole Sorensen
    • 1
  • Marion Coulter-Mackie
    • 1
  • Dean Percy
    • 1
  • Samuel Dales
    • 1
  1. 1.Cytobiology Group, Department of Microbiology and ImmunologyUniversity of Western OntarioLondonCanada

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