Biochemistry of Coronaviruses 1980
The coronavirus is something of a wolf in sheep’s clothing. Originally identified as a large pleomorphic enveloped RNA virus with unique external morphological features and a helical internal nucleocapsid (Tyrrell et al., 1975), the close parallels with negative strand RNA viruses prompted many investigators to search for a coronavirion transcriptase. It soon became clear however, that, despite their morphological appearance, the coronaviruses possess an infectious genome RNA which must, by definition, be of positive polarity.
KeywordsInfectious Bronchitis Virus Human Coronavirus Murine Hepatitis Virus Avian Infectious Bronchitis Virus Murine Coronavirus
- Evans, M.R. and Simpson, R.W. (1980). The coronavirus avian infectious bronchitis virus requires the cell nucleus and host transcritpional factors. Frisby, D., Smith, J., Jeffers, V. and Porter, A. (1976). Size and location of poly (A) in encephalomyocarditis virus RNA. Nucleic Acids Res. 3, 2789–2809.Google Scholar
- Siddell, S.G., Barthel, A. and ter Meulen, V. (1981). Coronavirus JHM. A virion-associated protein kinase. J. gen. Virol. 52, in press.Google Scholar
- Tyrrell, D.A.J., Almeida, J.D., Cunningham, C.H., Dowdle, W.R., Hofstad, M.S., McIntosh, K., Tajima, M., Zakstelskaya, L.Y., Easterday, B.C., Kapikian, A. and Bingham, R.W. (1975). Coronaviridae. Intervirology 5, 76–82.Google Scholar