Non-Lymphoid Cells from Rat Intestinal Lymph

  • C. W. Pugh
  • G. G. MacPherson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


Peripheral lymph of all mammalian species examined contains a subpopulation of nonlymphoid cells (NLC) absent from central lymph (1). These cells have often been considered to be mononuclear phagocytes on the basis of their strikingly irregular surface morphology. In the past, investigation of the properties of these cells has been restricted to large experimental animals in which direct cannulation of peripheral lymphatics is feasible (2,3). The lack of inbred strains of these animals has hampered attempts to analyze functional properties of NLC. However, it has been found that following mesenteric lymphadenectomy in the rat NLC appear in thoracic duct lymph. These NLC show marked heterogeneity with regard to their surface morphology as visualized by scanning electron microscopy, some being veiled while others have fine or blunt pseudopodia. The cells also vary in the amount of nonspecific esterase activity and endogenous peroxidatic activity they display (4). These cells are derived locally from intestinal lymph draining both Peyer’s patch and non-Peyer’s patch areas (4). In this paper we show that they are of bone marrow origin and turnover rapidly.


Stimulatory Capacity Mixed Leukocyte Reaction Intestinal Lymph Thoracic Duct Lymph Peripheral White Blood Cell Count 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • C. W. Pugh
    • 1
  • G. G. MacPherson
    • 1
  1. 1.Sir William Dunn School of PathologyOxfordUK

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