The Structure of the Genome

  • John S. Sussenbach
Chapter
Part of the The Viruses book series (VIRS)

Abstract

Adenovirus particles have a highly ordered structure and are composed of protein and DNA. Human adenoviruses contain about 87% protein and 13% DNA (Green and Piña, 1963), while the larger avian chick embryo lethal orphan (CELO) virus consists of 83% protein and 17% DNA (Laver et al., 1971). In virions, the viral DNA is tightly associated with several virus-coded proteins. Disruption of virions with acetone, urea, or pyridine, or repeated freezing and thawing, releases the viral cores, which, in addition to the viral DNA, still contain about 18–20% of the total protein of the virions (Laver et al., 1967, 1968; Maizel et al., 1968; Prage et al., 1968, 1970). The proteins found in viral cores are mainly two basic polypeptides. The major core protein is identical to polypeptide VII [molecular weight 18,000 (18K)], of which about 1000 copies are present in each viral particle. The minor core protein is polypeptide V (molecular weight 45.5K), of which each virion contains about 200 copies (Laver et al., 1968; Prage et al., 1968, 1970; Prage and Pettersson, 1971; Russell et al., 1971; Everitt et al., 1973; Laver, 1970). However, when cores are prepared by extraction of virions with sarkosyl, only polypeptide VII is found associated with the DNA (Brown et al., 1975). The different protein compositions of pyridine and sarkosyl cores suggest that polypeptide VII is more intimately associated with the viral genome than is polypeptide V.

Keywords

Inverted Terminal Repetition Early Region Adenovirus Type Human Adenovirus Terminal Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Akusjärvi, G., and Persson, H., 1981a, Gene and mRNA for precursor polypeptide VI from adenovirus type 2,J. Virol 38:469.PubMedGoogle Scholar
  2. Akusjärvi, G., and Persson, H., 1981b, Control of RNA splicing and termination in the major late adenovirus transcription unit, Nature (London) 292:420.Google Scholar
  3. Akusjärvi, G., and Pettersson, U., 1978a, Sequence analysis of adenovirus DNA. I. Nucleotide sequence at the carboxy-terminal end of the gene for adenovirus type 2 hexon, Virology 91:477.PubMedGoogle Scholar
  4. Akusjärvi, G., and Pettersson, U., 1978b, Nucleotide sequence at the junction between the coding region of the adenovirus 2 hexon messenger RNA and its leader sequence, Proc. Natl Acad. Sci. U.S.A. 75:5822.PubMedGoogle Scholar
  5. Akusjärvi, G., and Pettersson, U., 1979a, Sequence analysis of adenovirus DNA: Complete nucleotide sequence of the spliced 5′-non-coding region of adenovirus 2 hexon messenger RNA, Cell 16:841.PubMedGoogle Scholar
  6. Akusjärvi, G., and Pettersson, U., 1979b, Sequence analysis of adenovirus DNA. IV. The genomic sequences encoding the common tripartite leader of late adenovirus messenger RNA,J. Mol Biol 13:143.Google Scholar
  7. Akusjärvi, G., Mathews, M.B., Anderson, P., Vennström, B., and Pettersson, U., 1980, Structure of genes for virus-associated RNAI and RNAII of adenovirus type 2, Proc. Natl Acad. Sci. U.S.A. 77:2424.PubMedGoogle Scholar
  8. Akusjärvi, G., Zabielsky, J., Perricaudet, M., and Pettersson, U., 1981, The sequence of the 3′ non-coding region of the hexon mRNA discloses a novel adenovirus gene, Nucleic Acids Res. 9:1.PubMedGoogle Scholar
  9. Aleström, P., Akusjärvi, G., Perricaudet, M., Mathews, M.B., Klessig, D., and Pettersson, U., 1980, Sequence analysis of adenovirus DNA. VI. The nucleotide sequence of the gene for polypeptide IX from adenovirus type 2 and its colinear messenger RNA, Cell 19:671.PubMedGoogle Scholar
  10. Aleström, P., Stenlund, A., Li, P., and Pettersson, U., 1982a, A common sequence in the inverted terminal repetitions of human and avian adenoviruses, Gene 18:193.PubMedGoogle Scholar
  11. Aleström, P., Akusjärvi, G., Pettersson, M., and Pettersson, U., 1982b, DNA sequence analysis of the region encoding the terminal protein and the hypothetical N-gene product of adenovirus type 2,J. Biol. Chem. 257:13492.PubMedGoogle Scholar
  12. Anderson, C.W., and Lewis, J.B., 1980, Amino-terminal sequence of the adenovirus type 2 proteins: Hexon, fiber, component IX and the early protein 1B-15 K, Virology 104:27.PubMedGoogle Scholar
  13. Ariga, H., Shimojo, H., Hidaka, S., and Miura, M., 1979, Specific cleavage of the terminal protein from the adenovirus 5 DNA under the conditions of single-strand scission by nuclease S1, FEBS Lett. 107:355.PubMedGoogle Scholar
  14. Ariga, H., Klein, H., Levine, A.J., and Horwitz, M.S., 1980, A cleavage product of the adenovirus DNA binding protein is active for DNA replication in vitro, Virology 101:307.PubMedGoogle Scholar
  15. Arrand, J.R., and Roberts, R.J., 1979, The nucleotide sequences at the termini of adenovirus 2 DNA, J. Mol Biol. 128:577.PubMedGoogle Scholar
  16. Arrand, J.R., Keller, W., and Roberts, R.J., 1975, Extent of terminal repetition in adenovirus 2 DNA, Cold Spring Harbor Symp. Quant. Biol. 39:401.PubMedGoogle Scholar
  17. Baker, C.C., and Ziff, E.B., 1980, Biogenesis, structures, and sites of encoding of the 5′ termini of adenovirus-2 mRNAs, Cold Spring Harbor Symp. Quant. Biol. 44:415.PubMedGoogle Scholar
  18. Baker, C.C., and Ziff, E.B., 1981, Promoters and heterogeneous 5′-termini of the messenger RNAs of adenovirus-2, J. Mol Biol. 149:189.PubMedGoogle Scholar
  19. Baker, C.C., Hérissé, J., Courtois, G., Galibert, F., and Ziff, E., 1979, Messenger RNA for the Ad2 DNA binding protein: DNA sequences encoding the first leader and heterogeneity at the mRNA 5′ end, Cell 8:569.Google Scholar
  20. Bartok, K., Garon, C.F., Berry, K.W., and Rose, J.A., 1974, Specific fragmentation of adenovirus heteroduplex DNA molecules with single-strand specific nuclease of Neurospora crassa, J. Mol Biol. 87:437.PubMedGoogle Scholar
  21. Bégin, M., and Weber, J., 1975, Genetic analysis of adenovirus type 2. I. Isolation and genetic characterization of temperature-sensitive mutants,J. Virol. 115:1.Google Scholar
  22. Berget, S.M., Moore, C., and Sharp, P.A., 1977, Spliced segments at the 5′ terminus of adenovirus 2 late mRNA, Proc. Natl. Acad. Sci. U.S.A. 74:3171.PubMedGoogle Scholar
  23. Berget, S.M., Berk, A., Harrison, T., and Sharp, P.A., 1978, Spliced segments at the 5′ termini of adenovirus 2 late mRNA: A role for heterogeneous nuclear RNA in mammalian cells, Cold Spring Harbor Symp. Quant. Biol. 42:523.PubMedGoogle Scholar
  24. Berk, A.J., and Sharp, P.A., 1977a, Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease digested hybrids, Cell 12:721.PubMedGoogle Scholar
  25. Berk, A.J., and Sharp, P.A., 1977b, UV mapping of the adenovirus 2 early promoters, Cell 12:45.PubMedGoogle Scholar
  26. Berk, A.J., and Sharp, P.A., 1978, Structure of the adenovirus 2 early mRNAs, Cell 14:695.PubMedGoogle Scholar
  27. Berk, A.J., Lee, F., Harrison, T., Williams, J., and Sharp, P.A., 1979, Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNA, Cell 17:935.PubMedGoogle Scholar
  28. Bernards, R., Houweling, A., Schrier, P.I., Bos, J.L., and van der Eb, A.J., 1982, Characterization of cells transformed by Ad5/Ad12 hybrid early region 1 plasmids, Virology 120:422.PubMedGoogle Scholar
  29. Bhatti, A.R., and Weber, J., 1979, Protease of adenovirus type 2,J. Biol. Chem. 254:12265.Google Scholar
  30. Binger, M.H., Flint, S.J., and Rekosh, D.M., 1982, Expression of the gene encoding the adenovirus DNA terminal protein precursor in productively infected and transformed cells,J. Virol. 42:488.PubMedGoogle Scholar
  31. Bos, J.L., Polder, L.J., Bernards, R., Schrier, P.I., van den Elsen, P., Van der Eb, A.J., and van Ormondt, H., 1981, The 2.2 kb mRNA of human Adl2 and Ad5 codes for two tumor antigens starting at different AUG triplets, Cell 27:121.PubMedGoogle Scholar
  32. Brackman, K.H., Green, M., Wold, W.S.M., Cartas, M., Matsuo, T., and Hashimoto, S., 1980, Identification and peptide mapping of human adenovirus type 2-induced early polypeptides isolated by two-dimensional gel electrophoresis,J. Biol. Chem. 255:6772.Google Scholar
  33. Broker, T.R., Chow, L.T., Dunn, A.R., Gelinas, R.E., Hassell, J.A., Klessig, D.F., Lewis, J.B., Roberts, R.J., and Zain, B.S., 1977, Adenovirus-2 messengers—An example of baroque molecular architecture, Cold Spring Harbor Symp. Quant. Biol. 42:531.Google Scholar
  34. Brown, D.T., Westphal, M., Burlingham, B.T., Winterhoff, U., and Doerfler, W., 1975, Structure and composition of the adenovirus type 2 core,J. Virol. 16:366.PubMedGoogle Scholar
  35. Burnett, J.P., and Harrington, J.A., 1968, Simian adenovirus SA7 DNA: Chemical, physical and biological studies, Proc. Natl Acad. Sci. U.S.A. 60:1023.PubMedGoogle Scholar
  36. Carter, T.H., and Blanton, R.A., 1978, Possible role of the 72,000-dalton DNA-binding protein in regulation of adenovirus type 5 early gene expression,J. Virol. 25:664.PubMedGoogle Scholar
  37. Carter, T.H., and Ginsberg, H.S., 1976, Viral transcription in KB cells infected by temperature-sensitive early mutants of adenovirus type 5,J. Virol. 18:156.PubMedGoogle Scholar
  38. Carusi, E.A., 1977, Evidence for blocked 5′ termini in human adenovirus DNA, Virology 76:380.PubMedGoogle Scholar
  39. Celma, M.L., Pan, J., and Weissmann, S., 1977a, Studies of low molecular weight RNA from cells infected with adenovirus 2. I. The sequence at the 3′ end of VA-RNA 1,J. Biol. Chem. 252:9032.PubMedGoogle Scholar
  40. Celma, M.L., Pan, J., and Weissmann, S., 1977b, Studies of low molecular weight RNA from cells infected with adenovirus 2. II. Heterogeneity at the 5′ end of VA-RNA 1,J. Biol. Chem. 252:9043.PubMedGoogle Scholar
  41. Challberg, M.D., and Kelly, T.J., Jr., 1979a, Adenovirus DNA replication in vitro, Proc. Natl. Acad. Sci. U.S.A. 76:655.PubMedGoogle Scholar
  42. Challberg, M.D., and Kelly, T.J., Jr., 1979b, Adenovirus DNA replication in vitro: Origin and direction of daughter strand synthesis,J. Mol. Biol. 135:999.PubMedGoogle Scholar
  43. Challberg, M.D., and Kelly, T.J., Jr., 1981, Processing of the adenovirus terminal protein, J. Virol. 38:272.PubMedGoogle Scholar
  44. Challberg, M.D., Desiderio, S.V., and Kelly, T.J., Jr., 1980, Adenovirus DNA replication in vitro: Characterization of a protein covalently linked to nascent DNA strands, Proc. Natl. Acad. Sci. U.S.A. 77:5105.PubMedGoogle Scholar
  45. Chinnadurai, G., Chinnadurai, S., and Green, M., 1978, Enhanced infectivity of adenovirus DNA and a DNA-protein complex,J. Virol. 26:195.PubMedGoogle Scholar
  46. Chow, L.T., and Broker, T.R., 1978, The spliced structures of adenovirus-2 fiber message and the other mRNAs, Cell 15:497.PubMedGoogle Scholar
  47. Chow, L.T., Gelinas, R.E., Broker, T.R., and Roberts, R.J., 1977a, An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA, Cell 12:1.PubMedGoogle Scholar
  48. Chow, L.T., Roberts, J.M., Lewis, J.B., and Broker, T.R., 1977b, A cytoplasmic RNA transcript map from adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids, Cell 11:819.PubMedGoogle Scholar
  49. Chow, L.T., Broker, T.R., and Lewis, J.B., 1979a, Complex splicing patterns of RNAs from the adenovirus 2,J. Mol. Biol. 134:265.PubMedGoogle Scholar
  50. Chow, L., Lewis, J.B., and Broker, T., 1979b, RNA transcription and splicing at early and intermediate times after adenovirus-2 infection, Cold Spring Harbor Symp. Quant. Biol. 44:401.Google Scholar
  51. Coombs, D.H., and Pearson, G.D., 1978, Filter-binding assay for covalent DNA-protein complexes: Adenovirus DNA-terminal protein complex, Proc. Natl. Acad. Sci. U.S.A. 75:5291.PubMedGoogle Scholar
  52. Coombs, D.H., Robinson, A.J., Bodnar, J.W., Jones, Cf., and Pearson, G.D., 1978, Detection of DNA-protein complexes: The adenovirus DNA-terminal protein and HeLa DNA-protein complexes, Cold Spring Harbor Symp. Quant. Biol. 43:741.Google Scholar
  53. Corden, J., Engelking, H.M., and Pearson, G.D., 1976, Chromatin-like organization of the adenovirus chromosome, Proc. Natl. Acad. Sci. U.S.A. 73:401.PubMedGoogle Scholar
  54. Desiderio, S.V., and Kelly, T., 1981, Structure of the linkage between adenovirus DNA and the 55,000 molecular weight terminal protein,J. Mol. Biol. 145:319.PubMedGoogle Scholar
  55. Dijkema, R., and Dekker, B.M.M., 1979, The inverted terminal repetition of the DNA of the weakly oncogenic adenovirus type 7, Gene 8:7.PubMedGoogle Scholar
  56. Dijkema, R., Dekker, B.M.M., and van Ormondt, H., 1980a, The nucleotide sequence of the transforming BglII-H fragment of adenovirus type 7 DNA, Gene 9:141.PubMedGoogle Scholar
  57. Dijkema, R., Dekker, B.M.M., van Ormondt, H., Maat, J., and Boyer, H., 1980b, Gene organization of the transforming region of weakly oncogenic adenovirus type 7: The Ela region, Gene 12:287.PubMedGoogle Scholar
  58. Dijkema, R., Maat, J., Dekker, B.M.M., van Ormondt, H., and Boyer, W., 1981, The gene for polypeptide IX of adenovirus type 7, Gene 13:375.PubMedGoogle Scholar
  59. Dijkema, R., Dekker, B.M.M., and van Ormondt, H., 1982, Gene organization of the transforming region of adenovirus type 7, Gene 18:143.PubMedGoogle Scholar
  60. Dimitrov, D.H., Dubitchev, A.G., Naroditsky, B.S., Dreizin, R.S., and Tikchonenko, T.I., 1979, Physicochemical properties and restriction maps of simian adenovirus 38,J. Gen. Virol. 44:69.PubMedGoogle Scholar
  61. Doerfler, W., and Kleinschmidt, A., 1970, Denaturation pattern of the DNA of adenovirus type 2 as determined by electron microscopy,J. Mol. Biol. 50:579.PubMedGoogle Scholar
  62. Doerfler, W., Hellmann, W., and Kleinschmidt, A.K., 1972, The DNA of adenovirus type 12 and its denaturation pattern, Virology 47:507.PubMedGoogle Scholar
  63. Dunn, A.R., Mathews, M.B., Chow, L.T., Sambrook, J., and Keller, W., 1978, A supplementary adenoviral leader sequence and its role in messenger translation, Cell 15:511.Google Scholar
  64. Ellens, D.J., Sussenbach, J.S., and Jansz, H.S., 1974, Studies on the mechanism of replication of adenovirus DNA. III. Electron microscopy of replicating DNA, Virology 61:427.PubMedGoogle Scholar
  65. Engler, J., 1981, The nucleotide sequence of the polypeptide IX gene of human adenovirus type 3, Gene 13:387.PubMedGoogle Scholar
  66. Engler, J.A., and van Bree, M., 1982, The nucleotide sequence of the gene encoding protein IVa2 in human adenovirus type 7, Gene 19:71.PubMedGoogle Scholar
  67. Engler, J., Broker, T.R., and Chow, L.T., 1981, Sequences of human adenovirus Ad3 and Ad7 DNAs encoding the promoter and first leader segment of late RNAs, Gene 13:133.PubMedGoogle Scholar
  68. Engler, J.A., Hoppe, M.S., and van Bree, M.P., 1983, The nucleotide sequence of the genes encoded in the early region 2B in human adenovirus type 7, Gene 21:147.Google Scholar
  69. Enomoto, T., Lichy, J.H., Ikeda, J.E., and Hurwitz, J., 1981, Adenovirus DNA replication in vitro: Purification of the terminal protein in a functional form, Proc. Natl. Acad. Sci. U.S.A. 78:6779.PubMedGoogle Scholar
  70. Esche, H., Mathews, M.B., and Lewis, J.B., 1980, Proteins and messenger RNAs of the transforming region of wild-type and mutant adenoviruses,J. Mol. Biol. 142:399.PubMedGoogle Scholar
  71. Evans, R.M., Fraser, N., Ziff, E., Weber, J., Wilson, M., and Darnell, J.E., 1977, The initiation sites for RNA transcription in Ad2 DNA, Cell 12:733.PubMedGoogle Scholar
  72. Everitt, E., Sundquist, B., Petersson, O., and Philipson, L., 1973, Structural proteins of adenoviruses. X. Isolation and topography of low molecular weight antigens from the virion of adenovirus type 2, Virology 62:130.Google Scholar
  73. Forsblom, S., Rigler, R., Ehrenberg, M., Pettersson, U., and Philipson, L., 1976, Kinetic studies on the cleavage of adenovirus DNA by restriction endonuclease EcoRI, Nucleic Acids Res. 3:3255.PubMedGoogle Scholar
  74. Fraser, N., and Ziff, E., 1978, RNA structures near poly (A) of adenovirus-2 late messenger RNA’s,J. Mol. Biol. 124:27.PubMedGoogle Scholar
  75. Fraser, N.W., Nevins, J.R., Ziff, E., and Darnell, J.E., 1979, The major late adenovirus type 2 transcription unit: Termination is downstream from the last poly (A) site,J. Mol. Biol. 129:643.PubMedGoogle Scholar
  76. Fraser, N.W., Baker, C.C., Moore, M.A., and Ziff, E.B., 1982, Poly(A) sites of adenovirus serotype 2 transcription units,J. Mol. Biol. 155:207.PubMedGoogle Scholar
  77. Freeman, A.E., Black, P.E., Vanderpool, E.A., Henry, P.H., Austin, J.B., and Huebner, R.J., 1967, Transformation of primary rat embryo cells by adenovirus type 2, Proc. Natl. Acad. Sci. U.S.A. 58:1205.PubMedGoogle Scholar
  78. Frost, E., and Williams, J., 1978, Mapping of temperature-sensitive and host-range mutants of adenovirus type 5 by marker rescue, Virology 91:39.PubMedGoogle Scholar
  79. Fujinaga, K., Sawada, Y., Uemizu, Y., Yamashita, T., Shimojo, H., Shiroki, K., Sugisaki, H., Sugimoto, K., and Takanami, M., 1979, Nucleotide sequences, integration, and transcription of the adenovirus-12 transforming genes, Cold Spring Harbor Symp. Quant. Biol. 44:519.Google Scholar
  80. Galibert, F., Hérissé, J., and Courtois, G., 1979, Nucleotide sequence of the EcoRI-F fragment of adenovirus 2 genome, Gene 6:1.PubMedGoogle Scholar
  81. Gallimore, P.H., 1974, Interactions of adenovirus type 2 with rat embryo cells: Permissiveness, transformation and in vitro characteristics of adenovirus transformed rat embryo cells,J. Gen. Virol. 25:263.PubMedGoogle Scholar
  82. Galos, R.S., Williams, J., Binger, M.H., and Flint, S.J., 1979, Location of additional early gene sequences in the adenoviral chromosome, Cell 17:945.PubMedGoogle Scholar
  83. Gambke, C., and Deppert, W., 1981, Late non-structural 100,000 and 33,000 dalton proteins of adenovirus type 2. II. Immunological and protein chemical analysis,J. Virol. 40:594.PubMedGoogle Scholar
  84. Garon, C.F., Berry, K.W., and Rose, J.A., 1972, A unique form of terminal redundancy in adenovirus DNA molecules, Proc. Natl. Acad. Sci. U.S.A. 69 :2391.PubMedGoogle Scholar
  85. Garon, C.F., Berry, K.W., Hierholzer, J.C., and Rose, J.A., 1973, Mapping base sequence heterologies between genomes from different adenovirus serotypes, Virology 54:414.PubMedGoogle Scholar
  86. Garon, C.F., Berry, K.W., and Rose, J.A., 1975, Arrangement of sequences in the inverted terminal repetition of adenovirus 18 DNA, Proc. Natl. Acad. Sci. U.S.A. 72:3039.PubMedGoogle Scholar
  87. Garon, F.C., Parr, R.P., Padmanabhan, R., Roninson, I., Garrison, J.W., and Rose, J.A., 1982, Structural characterization of the adenovirus 18 inverted terminal repetition, Virology 121:230.PubMedGoogle Scholar
  88. Gingeras, T.R., Sciaky, D., Gelinas, R.E., Bing-Dong, J., Yen, CE., Kelly, M.M., Bullock, P.A., Parsons, B.L., O’Neill, K.E., and Roberts, R.J., 1982, Nucleotide sequences from the adenovirus-2 genome,J. Biol. Chem. 257:13475.PubMedGoogle Scholar
  89. Ginsberg, H.S., Ensinger, M.J., Kauffman, R.S., Mayer, A.J., and Lundholm, U., 1974, Cell transformation: A study of regulation with types 5 and 12 adenovirus temperaturesensitive mutants, Cold Spring Harbor Symp. Quant. Biol. 44:419.Google Scholar
  90. Girardi, A.J., Hilleman, M.R., and Zwickey, R.E., 1964, Tests in hamsters for oncogenic quality of ordinary viruses including adenovirus type 7, Proc. Soc. Exp. Biol. Med. 115:1141.PubMedGoogle Scholar
  91. Goldbach, R.W., Evers, R.F., and Borst, P., 1978, Electrophoretic strand separation of long DNAs with poly-UG in agarose gels, Nucleic Acids Res. 5:2743.PubMedGoogle Scholar
  92. Goodhearst, C.R., 1971, DNA density of oncogenic and non-oncogenic simian adenoviruses, Virology 44:645.Google Scholar
  93. Graham, F.L., and van der Eb, A.J., 1973, A new technique for the assay of the infectivity of human adenovirus 5 DNA, Virology 52:456.PubMedGoogle Scholar
  94. Graham, F.L., van der Eb, A.J., and Heijneker, H.L., 1974a, Size and location of the transforming regions of human adenovirus type 5 DNA, Nature (London) 251:687.Google Scholar
  95. Graham, F.L., Abrahams, P.J., Mulder, C., Heijneker, H.L., Warnaar, S.O., de Vries, F.A.J., Fiers, W., and van der Eb, A.J., 1974b, Studies on in vitro transformation by DNA and DNA fragments of human adenoviruses and simian virus 40, Cold Spring Harbor Symp. Quant. Biol. 39:637.Google Scholar
  96. Green, M., 1970, Oncogenic viruses, Annu. Rev. Biochem. 39:701.PubMedGoogle Scholar
  97. Green, M., and Piña, M., 1963, Biochemical studies on adenovirus multiplication. IV. Isolation, purification and chemical analysis of adenovirus, Virology 20:199.PubMedGoogle Scholar
  98. Green, M., and Piña, M., 1964, Biochemical studies on adenovirus multiplication. VI. Properties of highly purified tumorigenic human adenoviruses and their DNA’s, Proc. Natl. Acad. Sci. U.S.A. 51:1251.PubMedGoogle Scholar
  99. Green, M., Piña, M., Kimes, R., Wensink, P.C., Machattie, L.A., and Thomas, C.A., 1967, Adenovirus DNA. I. Molecular weight and conformation, Proc. Natl. Acad. Sci. U.S.A. 57:1302.PubMedGoogle Scholar
  100. Green, M., Parsons, J.T., Piña, M., Fujinaga, K., Caffier, H., and Landgraf-Leurs, I., 1970, Transcription of adenovirus genes in productively infected and transformed cells, Cold Spring Harbor Symp. Quant. Biol. 30:803.Google Scholar
  101. Green, M., Wold, W.S.M., Brackmann, K.H., and Cartas, M.A., 1979a, Identification of families of overlapping polypeptides coded by early “transforming” gene region 1 of human adenovirus type 2, Virology 97:275.PubMedGoogle Scholar
  102. Green, M., Mackey, J., Wold, W.S.M., and Rigden, P., 1979b, Thirty-one human adenovirus serotypes (Adl-Ad31) form five groups (A-E) based on upon DNA genome homologies, Virology 93:481.PubMedGoogle Scholar
  103. Green, M., Brackmann, K., Wold, W.S.M., Cartas, M., Thornton, H., and Elder, J.H., 1979c, Conserved primary sequences of the DNA terminal proteins of five different human adenovirus groups, Proc. Natl. Acad. Sci. U.S.A. 76:4380.PubMedGoogle Scholar
  104. Green, M., Wold, W.S.M., Brackmann, K., and Cartas, M.A., 1979d, Studies on early proteins and transformation proteins in human adenoviruses, Cold Spring Harbor Symp. Quant. Biol. 44:457.Google Scholar
  105. Grodzicker, T., Williams, J., Sharp, P.A., and Sambrook, J., 1975, Physical mapping of temperature-sensitive mutations of adenoviruses, Cold Spring Harbor Symp. Quant. Biol. 39:439.PubMedGoogle Scholar
  106. Grodzicker, T., Anderson, C.W., Sambrook, J., and Mathews, M.B., 1977, The physical location of structural genes in adenovirus DNA, Virology 80:111.PubMedGoogle Scholar
  107. Harrison, T., Graham, F.L., and Williams, J., 1977, Host range mutants of adenovirus type 5 defective for growth in HeLa cells, Virology 77:319.PubMedGoogle Scholar
  108. Harter, M.L., and Lewis, J.B., 1978, Adenovirus type 2 early proteins synthesized in vitro and in vivo: Identification in infected cells of the 38,000- to 50,000-molecular-weight protein encoded by the left end of adenovirus type 2 genome,J. Virol. 26:736.PubMedGoogle Scholar
  109. Harter, M.L., Shanmugan, G., Wold, W.S.M., and Green, M., 1976, Detection of adenovirus type 2 induced early polypeptides using cycloheximide pretreatment to enhance viral protein synthesis,J. Virol. 19:1976.Google Scholar
  110. Hashimoto, S., Pursley, M.H., and Green, M., 1981, Nucleotide sequences and mapping of novel heterogeneous 5′-termini of adenovirus type 2 early region 4 mRNA, Nucleic Acids Res. 9:1675.PubMedGoogle Scholar
  111. Hérissé, J., and Galibert, F., 1981, Nucleotide sequence of the EcoRI E fragment of adeno-virus-2 genome, Nucleic Acids Res. 9:1229.PubMedGoogle Scholar
  112. Hérissé, J., Courtois, G., and Galibert, F., 1980, Nucleotide sequence of the EcoRI D fragment of adenovirus 2 genome, Nucleic Acids Res. 8:2173.PubMedGoogle Scholar
  113. Hérissé, J., Rigolet, M., Dupont de Dinechin, S., and Galibert, F., 1981, Nucleotide sequence of adenovirus 2 fragment encoding for the carboxylic region of the fiber protein and the entire E4 region, Nucleic Acids Res. 9:4023.PubMedGoogle Scholar
  114. Hierholzer, J.C., 1973, Further subgrouping of the human adenoviruses by differential hemagglutination,J. Infect Dis. 128:541.PubMedGoogle Scholar
  115. Horwitz, M.S., 1974, Location of the origin of DNA replication in adenovirus type 2,J. Virol. 13:1046.PubMedGoogle Scholar
  116. Horwitz, M.S., 1978, Temperature-sensitive replication of H5ts125 adenovirus DNA in the presence of cycloheximide,J. Virol. 11:544.Google Scholar
  117. Houweling, A., van den Elsen, P.J., and van der Eb, A.J., 1980, Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA, Virology 105:537.PubMedGoogle Scholar
  118. Huebner, R.J., Rowe, W.P., and Lane, W.T., 1962, Oncogenic effects in hamsters of human adenovirus types 12 and 18, Proc. Natl. Acad. Sci. U.S.A. 48:2051.PubMedGoogle Scholar
  119. Huebner, R.J., Casey, M.J., Chanock, R.M., and Schell, K., 1965, Tumors induced in hamsters by a strain of adenovirus type 3: Sharing of tumor antigens and neoantigens with those produced by adenovirus type 7 tumors, Proc. Soc. Exp. Biol. Med. 54:381.Google Scholar
  120. Jones, N., and Shenk, T., 1979a, An adenovirus type 5 early gene function regulates expression of other early viral genes, Proc. Natl. Acad. Sci. U.S.A. 76:3665.PubMedGoogle Scholar
  121. Jones, N., and Shenk, T., 1979b, Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells, Cell 17:683.PubMedGoogle Scholar
  122. Jörnvall, H., Akusjärvi, G., Aleström, P., von Bahr-Lindstrom, H., Pettersson, U., Appella, E., Fowler, A.V., and Philipson, L., 1981a, The adenovirus hexon protein: The primary structure of the polypeptide and its correlation with the hexon gene,J. Biol. Chem. 256:6181.PubMedGoogle Scholar
  123. Jörnvall, H., Aleström, P., Akusjärvi, G., von Bahr-Lindstrom, H., Philipson, L., and Pettersson, U., 1981b, Order of the CNBr fragments in the adenovirus hexon protein,J. Biol. Chem. 256:6204.PubMedGoogle Scholar
  124. Keegstra, W.S., van Wielink, P.S., and Sussenbach, J.S., 1977, The visualization of a circular DNA-protein complex from adenovirions, Virology 76:444.PubMedGoogle Scholar
  125. Kilpatrick, B.A., Gelinas, R.E., Broker, T.R., and Chow, L.T., 1979, Comparison of late mRNA splicing among class B and class C adenoviruses,J. Virol. 30:899.PubMedGoogle Scholar
  126. Kimes, R., and Green, M., 1970, Adenovirus DNA. IL Separation of molecular halves of adenovirus type 2,J. Mol. Biol. 50:203.PubMedGoogle Scholar
  127. Kimura, T., Sawada, Y., Shinagawa, M., Shimizu, Y., Shiroki, K., Shimojo, H., Sugisaki, H., Takanami, M., Uemizu, Y., and Fujinaga, K., 1981, Nucleotide sequence of the transforming early region E1b of adenovirus 12 DNA: Structure and gene organization and comparison with those of adenovirus type 5 DNA, Nucleic Acids Res. 9:6571.PubMedGoogle Scholar
  128. Kitchingman, G.R., and Westphal, H., 1980, The structure of adenovirus 2 early nuclear and cytoplasmics RNAs.J. Mol. Biol. 137:23.PubMedGoogle Scholar
  129. Kitchingman, G.R., Lai, S.-P., and Westphal, H., 1977, Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA, Proc. Natl. Acad. Sci. U.S.A. 74:4329.Google Scholar
  130. Klessig, D.F., and Grodzicker, T., 1979, Mutations that allow human Ad2 and Ad5 to express late genes in monkey cells map in the viral gene encoding the 72K DNA binding protein, Cell 17:957.PubMedGoogle Scholar
  131. Kruijer, W., van Schaik, F.M.A., and Sussenbach, J.S., 1980, Nucleotide sequence analysis of a region of adenovirus 5 DNA encoding a hitherto unidentified gene, Nucleic Acids Res. 8:6033.PubMedGoogle Scholar
  132. Kruijer, W., van Schaik, F.A.M., and Sussenbach, J.S., 1981, Structure and organization of the gene coding for the DNA binding protein of adenovirus type 5, Nucleic Acids Res. 9:4439.PubMedGoogle Scholar
  133. Kruijer, W., van Schaik, F.A.M., and Sussenbach, J.S., 1982, Nucleotide sequence of the gene encoding adenovirus type 2 DNA binding protein, Nucleic Acids Res. 10:4493.PubMedGoogle Scholar
  134. Kruijer, W., van Schaik, F.A.M., Speyer, J.G., and Sussenbach, J.S., 1983, Structure and function of denovirus DNA binding protein: comparison of the amino acid sequences of Ad5 and Ad12 proteins derived from the nucleotide sequence of the corresponding genes, Virology 128:140.PubMedGoogle Scholar
  135. Kubinski, H., and Rose, J.A., 1967, Regions containing repeating base-pairs in DNA from some oncogenic and non-oncogenic animal viruses, Proc. Natl. Acad. Sci. U.S.A. 57:1720.PubMedGoogle Scholar
  136. Landgraf-Leurs, M., and Green, M., 1971, Adenovirus DNA. III. Separation of the complementary strands of adenovirus types 2, 7 and 12 DNA molecules,J. Mol. Biol. 60:185.PubMedGoogle Scholar
  137. Larsen, S.H., Margolskee, R.F., and Nathans, D., 1979, Alignment of the restriction map of mouse adenovirus FL and human adenovirus type 2, Virology 97:406.PubMedGoogle Scholar
  138. Larson, V.M., Girardi, A.J., Hilleman, M.R., and Zwickey, R.E., 1965, Studies on oncogenicity of adenovirus type 7 viruses in hamsters, Proc. Soc. Exp. Biol. Med. 118:15.PubMedGoogle Scholar
  139. Laver, W.G., 1970, Isolation of an arginine-rich protein from particles of adenovirus type 2, Virology 41:488.PubMedGoogle Scholar
  140. Laver, W.G., Suriano, J.R., and Green, M., 1967, Adenovirus proteins. II. N-terminal amino acid analysis,J. Virol. 1:723.PubMedGoogle Scholar
  141. Laver, W.G., Pereira, H.G., Russell, W.C., and Valentine, R.C., 1968, Isolation of an internal component of adenovirus type 5,J. Mol. Biol. 37:379.PubMedGoogle Scholar
  142. Laver, W.G., Younghusband, H.B., and Wrigley, N.G., 1971, Purification and properties of chick embryo lethal orphan virus (CELO), Virology 45:598.PubMedGoogle Scholar
  143. Lewis, J.B., and Mathews, M.B., 1980, Control of adenovirus early gene expression: A class of “immediate early” products, Cell 21:303.PubMedGoogle Scholar
  144. Lewis, J.B., Atkins, J.F., Anderson, C.W., Baum, P.R., and Gesteland, R.F., 1975, Mapping of late adenovirus genes by cell-free translation of RNA selected by hybridization to specific DNA fragments, Proc. Natl. Acad. Sci. U.S.A. 72:1344.PubMedGoogle Scholar
  145. Lewis, J.B., Atkins, J.F., Baum, P.R., Solem, R., Gesteland, R.B., and Anderson, C.W., 1976, Location and identification of the genes for adenovirus type 2 early polypeptides, Cell 17:141.Google Scholar
  146. Lewis, J.B., Anderson, C.W., and Atkins, J.F., 1977, Further mapping of late adenovirus genes by cell-free translation of RNA selected by hybridization to specific DNA fragments, Cell 12:37.PubMedGoogle Scholar
  147. Lewis, J.B., Esche, H., Smart, J.E., Stillman, B.W., Harter, M.L., and Mathews, M.B., 1979, Organization and expression of the left third of the genome of adenovirus, Cold Spring Harbor Symp. Quant. Biol. 44:493.Google Scholar
  148. Lichy, J.H., Field, J., Horwitz, M.S., and Hurwitz, J., 1982, Separation of the adenovirus terminal protein precursor from its associated DNA polymerase: Role of both proteins in the initiation of adenovirus DNA replication, Proc. Natl. Acad. Sci. U.S.A. 79:5225.PubMedGoogle Scholar
  149. Lupker, J.H., Davis, A., Jochemsen, H., and van der Eb, A.J., 1980, In vitro synthesis of adenovirus type 5 T antigens. I. Translation of early region 1-specific RNA from lytically infected cells,J. Virol. 37:524.Google Scholar
  150. Maat, J., and van Ormondt, H., 1979, The nucleotide sequence of the transforming HindIII-G fragment of adenovirus type 5 DNA, Gene 6:75.PubMedGoogle Scholar
  151. Maat, J., van Beveren, C.P., and van Ormondt, H., 1980, The nucleotide sequence of adenovirus type 5 early region E-1: The region between map positions 8.0 (HindIII site) and 11.8 (SmaI site), Gene 10:27.PubMedGoogle Scholar
  152. Maizel, J.V., White, D.O., and Scarff, M.D., 1968, The polypeptides of adenovirus. II. Soluble proteins, cores, top components and structure of the virion, Virology 36:126.PubMedGoogle Scholar
  153. Mathews, M.B., 1980, Binding of adenovirus VA RNA to mRNA: A possible role in splicing?, Nature (London) 285:575.Google Scholar
  154. Mathews, M.B., and Pettersson, U., 1978, The low molecular weight RNA’s of adenovirus 2 infected cells,J. Mol. Biol. 119:293.PubMedGoogle Scholar
  155. Mathis, D.J., Elkaim, R., Kedinger, C., Sassone-Corsi, P., and Chambon, P., 1981, Specific in vitro initiation of transcription on the adenovirus type 2 early and late EII transcription units, Proc. Natl. Acad. Sci. U.S.A. 78:7383.PubMedGoogle Scholar
  156. Mautner, V., Williams, J., Sambrook, J., Sharp, P.A., and Grodzicker, T., 1975, The location of the genes coding for hexon and fibre proteins in adenovirus DNA, Cell 5:93.PubMedGoogle Scholar
  157. Mayer, A.J., and Ginsberg, H.S., 1977, Persistence of type 5 adenovirus DNA in cells transformed by the temperature-sensitive mutant H5ts125, Proc. Natl. Acad. Sci. U.S.A. 74:785.PubMedGoogle Scholar
  158. McAllister, R.M., Nicolson, M.O., Lewis, A.M., McPherson, I., and Huebner, R.J., 1969, Transformation of rat embryo cells by adenovirus type 1,J. Gen. Virol. 4:29.PubMedGoogle Scholar
  159. McBride, W.D., and Weiner, A., 1964, In vitro transformation of hamster kidney cells by human adenovirus type 12, Proc. Soc. Exp. Biol. Med. 115:870.PubMedGoogle Scholar
  160. McGrogan, M., and Raskas, H.J., 1978, Two regions of the adenovirus 2 genome specify families of late polysomal RNA’s containing common sequences, Proc. Natl. Acad. Sci. U.S.A. 75:625.PubMedGoogle Scholar
  161. Miller, S.J., Ricciardi, R.P., Roberts, B.E., Paterson, B.M., and Mathews, M.B., 1980, Arrangement of messenger RNAs and protein coding sequences in the major late transcription unit of adenovirus 2,J. Mol. Biol. 142:455.PubMedGoogle Scholar
  162. Mirza, M.A., and Weber, J., 1982, Structure of adenovirus chromatin, Biochim. Biophys. Acta 696:76.PubMedGoogle Scholar
  163. Montell, C., Fisher, E.F., Caruthers, M.H., and Berk, A.J., 1982, Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site, Nature (London) 295:380.Google Scholar
  164. Murray, V., and Holliday, R., 1979, Mechanism of RNA splicing for gene transcripts, FEBS Lett. 106:5.PubMedGoogle Scholar
  165. Naroditsky, B.S., Kolinina, T.I., Goldberg, E.Z., Borovik, A.S., Karamov, E.V., and Tikchonenko, T.I., 1980, Analysis of DNA from human adenovirus type 6 with restriction endonucleases HindIII, BglII, and BamHI, Biochim. Biopys. Acta 606:214.Google Scholar
  166. Nevins, J.R., 1981, Mechanism of activation of early viral transcription by the adenovirus E1A gene products, Cell 26:213.PubMedGoogle Scholar
  167. Nevins, J.R., and Darnell, J.E., 1978, Groups of adenovirus type 2 mRNA’s derived from a large primary transcript: Probably nuclear origin and possible common 3′-ends,J. Virol. 25:811.PubMedGoogle Scholar
  168. Nevins, J.R., and Jensen-Winkler, J.J., 1980, Regulation of early adenovirus transcription: A protein product of early region 2 specifically represses region 4 transcription, Proc. Natl. Acad. Sci. U.S.A. 77:1893.PubMedGoogle Scholar
  169. Nevins, J.R., Blanchard, J.M., and Darnell, J.E., 1980, Transcription units of adenovirus type 2: Termination of transcription beyond the poly(A) addition site in early regions 2 and 4,J. Mol. Biol. 144:377.PubMedGoogle Scholar
  170. Nicolson, M.O., and McAllister, R.M., 1972, Infectivity of human adenovirus 1 DNA, Virology 48:14.PubMedGoogle Scholar
  171. Ohe, K., 1972, Virus-coded origin of a low molecular weight RNA from KB cells infected with adenovirus 2, Virology 47:726.PubMedGoogle Scholar
  172. Ohe, K., and Weissmann, S., 1970, Nucleotide sequence of an RNA from cells infected with adenovirus 2, Science 167:879.PubMedGoogle Scholar
  173. Ohen, K., and Weissman, S., 1971, The nucleotide sequence of a low molecular weight RNA from cells infected with adenovirus 2,J. Biol. Chem. 246:6999.Google Scholar
  174. Padmanabhan, R., and Green, M., 1976, Evidence for palindromic sequences near the termini of adenovirus 2 DNA, Biochem. Biophys. Res. Commun. 69:860.PubMedGoogle Scholar
  175. Padmanabhan, R., and Padmanabhan, R.V., 1977, Specific interaction of a protein(s) near the termini of adenovirus 2 DNA, Biochem. Biophys. Res. Commun. 80:955.Google Scholar
  176. Pan, J., Celma, M.L., and Weissman, S.M., 1977, Studies of low molecular weight RNA from cells infected with adenovirus 2. III. The sequence of the promoter for VA-RNA I. J. Biol. Chem. 252:9047.PubMedGoogle Scholar
  177. Patch, C.T., Lewis, A.M., and Levine, A.S., 1972, Evidence for a transcriptional control region of SV40 in the adenovirus 2-SV40 hybrid, Ad2 + ND1, Proc. Natl. Acad. Sci. U.S.A. 69:3375.PubMedGoogle Scholar
  178. Pereira, M.S., Pereira, H.G., and Clarke, S.K., 1965, Human adenovirus type 31: A new serotype with oncogenic properties, Lancet 1:21.PubMedGoogle Scholar
  179. Perricaudet, M., Akusjärvi, G., Virtanen, A., and Pettersson, U., 1979, Structure of two spliced mRNA’s from the transforming region of human subgroup C adenoviruses, Nature (London) 281:694.Google Scholar
  180. Perricaudet, M., le Moullec, J.M., and Pettersson, U., 1980, The predicted structure of two adenovirus T-antigens, Proc. Natl. Acad. Sci. U.S.A. 77:3778.PubMedGoogle Scholar
  181. Persson, H., and Philipson, L., 1982, Regulation of adenovirus gene expression, Curr. Top. Microbiol. Immunol. 97:157.PubMedGoogle Scholar
  182. Persson, H., Pettersson, U., and Mathews, M.B., 1978, Synthesis of a structural polypeptide in the absence of viral DNA replication, Virology 90:67.PubMedGoogle Scholar
  183. Persson, H., Mathisen, B., Philipson, L., and Pettersson, U., 1979a, A maturation protein in adenovirus morphogenesis, Virology 93:198.PubMedGoogle Scholar
  184. Persson, H., Signas, C., and Philipson, L., 1979b, Purification and characterization of an early glycoprotein from adenovirus type 2 infected cells,J. Virol. 29:938.PubMedGoogle Scholar
  185. Persson, H., Jansson, M., and Philipson, L., 1980a, Synthesis and genomic site for an adenovirus type 2 early protein,J. Mol. Biol. 136:375.PubMedGoogle Scholar
  186. Persson, H., Jörnvall, H., and Zabielski, J., 1980b, Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: Identification and structure of the signal sequence, Proc. Natl. Acad. Sci. U.S.A. 77:6349.PubMedGoogle Scholar
  187. Pettersson, U., and Mathews, M.B., 1977, The gene and the messenger RNA for adenovirus polypeptide IX, Cell 12:741.PubMedGoogle Scholar
  188. Piña, M., and Green, M., 1965, Biochemical studies on adenovirus multiplication. IX. Chemical and base composition analysis of 28 human adenoviruses, Proc. Natl. Acad. Sci. U.S.A. 54:547.PubMedGoogle Scholar
  189. Ponomareva, T.I., Grodnitskaya, N.A., Goldberg, E.E., Chaplygina, N.M., Naroditsky, B.S., and Tikchonenko, T.I., 1979, Biological activity of intact and cleaved DNA of the simian adenovirus 7, Nucleic Acids Res. 5:3119.Google Scholar
  190. Prage, L., and Pettersson, U., 1971, Structural proteins of adenoviruses. VII. Purification and properties of an arginine-rich core protein from adenovirus type 2 and type 3, Virology 45:364.PubMedGoogle Scholar
  191. Prage, L., Pettersson, U., and Philipson, L., 1968, Internal base proteins in adenovirus, Virology 36:508.PubMedGoogle Scholar
  192. Prage, L., Pettersson, U., Hoglund, S., Lonberg-Holm, K., and Philipson, L., 1970, Structural proteins of adenoviruses. IV. Sequential degradation of the adenovirus type 2 virion, Virology 42:341.PubMedGoogle Scholar
  193. Price, R., and Penman, S., 1972, A distinct RNA polymerase activity, synthesizing 5.5S, 5S and 4S RNA in nuclei from adenovirus 2 infected HeLa cells,J. Mol. Biol. 70:435.PubMedGoogle Scholar
  194. Rekosh, D., 1981, Analysis of the DNA-terminal protein from different serotypes of human adenovirus,J. Virol. 40:329.PubMedGoogle Scholar
  195. Rekosh, D.M.K., Russell, W.C., Bellett, A.J.D., and Robinson, A.J., 1977, Identification of a protein linked to the ends of adenovirus DNA, Cell 11:283.PubMedGoogle Scholar
  196. Rijnders, A.W.M., van Maarschalkerweerd, M.W., Visser, L., Reemst, A.M.C.B., Sussenbach, J.S., and Rozijn, T.H., 1983, Expression of integrated viral DNA sequences outside the transforming region in eight adenovirus-transformed cell lines, Biochim. Biophys. Acta 739:48.PubMedGoogle Scholar
  197. Roberts, R.J., 1981, Restriction and modification enzymes and their recognition sequences, Nucleic Acids Res. 9:r75.PubMedGoogle Scholar
  198. Roberts, R.J., Arrand, J.R., and Keller, W., 1974, The length of the terminal repetition in adenovirus-2 DNA, Proc. Natl. Acad. Sci. U.S.A. 71:3829.PubMedGoogle Scholar
  199. Robinson, A.J., and Bellett, A.J.D., 1975a, A circular DNA-protein complex from adenovirus and its possible role in DNA replication, Cold Spring Harbor Symp. Quant. Biol. 39:523.PubMedGoogle Scholar
  200. Robinson, A.J., and Bellett, A.J.D., 1975b, Complementary strands of CELO virus DNA,J. Virol. 15:458.PubMedGoogle Scholar
  201. Robinson, A.J., Younghusband, H.B., and Bellett, A.J.D., 1973, A circular DNA-protein complex from adenoviruses, Virology 56:54.PubMedGoogle Scholar
  202. Roninson, I., and Padmanabhan, R., 1980, Studies on the nature of the linkage between the terminal protein and the adenovirus DNA, Biochem. Biophys. Res. Commun. 94:398.PubMedGoogle Scholar
  203. Rósen, L., 1960, A hemagglutination-inhibition technique for typing adenoviruses, Am. J. Hyg. 71:120.PubMedGoogle Scholar
  204. Ross, S., Flint, S.J., and Levine, A.J., 1980, Identification of the adenovirus early proteins and their genomic positions, Virology 100:419.PubMedGoogle Scholar
  205. Russell, W.C., Mcintosh, K., and Skehel, J.J., 1971, The preparation and properties of adenovirus cores,J. Gen. Virol. 11:35.PubMedGoogle Scholar
  206. Sambrook, J., Williams, J.F., Sharp, P.A., and Grodzicker, T., 1975, Physical mapping of temperature-sensitive mutations of adenoviruses.J. Mol. Biol. 97:369.PubMedGoogle Scholar
  207. Schwarz, E., Reinke, C., Yamamoto, N., and Zur Hausen, H., 1982, Terminal rearrangements in the genome of adenovirus type 12 mutants adapted to growth in two human tumor cell lines, Virology 116:284.PubMedGoogle Scholar
  208. Seghal, P., Fraser, N., and Darnell, J., 1979, Early Ad2 transcription units: Only promoter-proximal RNA continues to be made in the presence of DRB, Virology 94:185.Google Scholar
  209. Sekikawa, K., Shiroki, K., Shimojo, H., Ojima, S., and Fujinaga, K., 1978, Transformation of a rat cell line by an adenovirus 7 DNA fragment Virology 88:1.PubMedGoogle Scholar
  210. Sharp, P.A., Gallimore, P.H., and Flint, S.J., 1975, Mapping of adenovirus 2 RNA sequences in lytically infected cells and transformed cell lines, Cold Spring Harbor Symp. Quant. Biol. 39:457.PubMedGoogle Scholar
  211. Sharp, P.A., Moore, C., and Haverty, J., 1976, The infectivity of adenovirus 5-DNA protein complex, Virology 75:442.PubMedGoogle Scholar
  212. Shaw, A.R., and Ziff, E.B., 1980, Transcripts from the adenovirus-2 late promoter yields a single family of coterminal mRNA’s during early infection and five families at late times, Cell 22:905.PubMedGoogle Scholar
  213. Shinagawa, M., and Padmanabhan, R., 1979, Nucleotide sequences at the inverted terminal repetition of Ad2 DNA, Biochem. Biophys. Res. Commun. 87:671.PubMedGoogle Scholar
  214. Shinagawa, M., and Padmanabhan, R., 1980, Comparative sequence analysis of the inverted terminal repetitions from different adenoviruses, Proc. Natl. Acad. Sci. U.S.A. 77:3831.PubMedGoogle Scholar
  215. Shinagawa, M., Padmanabhan, R.V., and Padmanabhan, R., 1980, The nucleotide sequence of the right-hand terminal Smal-K fragment of adenovirus type 2 DNA, Gene 9:99.PubMedGoogle Scholar
  216. Smart, J.E., and Stillman, B.W., 1982, Adenovirus terminal protein precursor: Partial amino acid sequence and the site of covalent linkage to virus DNA,J. Biol. Chem. 257:13499.PubMedGoogle Scholar
  217. Söderland, H., Pettersson, U., Vennström, B., Philipson, L., and Mathews, M.B., 1976, A new species of virus-coded low molecular weight RNA from cells infected with adenovirus type 2, Cell 7:585.Google Scholar
  218. Spector, D.J., McGrogan, M., and Raskas, H.J., 1978, Regulation of the appearance of cytoplas5mic RNA’s from region 1 of the adenovirus genome,J. Mol. Biol. 126:395.PubMedGoogle Scholar
  219. Spector, D.J., Crossland, L.D., Halbert, D.N., and Raskas, H.J., 1980a, A 28 K polypeptide is the translation product of 9 S RNA encoded by region 1A of adenovirus 2, Virology 102:218.PubMedGoogle Scholar
  220. Spector, D.J., Halbert, D.N., Crossland, L.D., and Raskas, HJ., 1980b, Expression of genes from the transforming region of adenovirus, Cold Spring Harbor Symp. Quant. Biol. 44:437.PubMedGoogle Scholar
  221. Steenbergh, P.H., and Sussenbach, J.S., 1979, The nucleotide sequence of the right-hand terminus of adenovirus type 5 DNA: Implications for the mechanism of DNA replication, Gene 6:307.PubMedGoogle Scholar
  222. Steenbergh, P.H., Maat, f., van Ormondt, H., and Sussenbach, J.S., 1977, The nucleotide sequence at the termini of adenovirus type 5 DNA, Nucleic Acids Res. 4:4371.PubMedGoogle Scholar
  223. Stenlund, A., Perricaudet, M., Tiollais, P., and Pettersson, U., 1980, Construction of restriction enzyme fragment libraries containing DNA from human adenovirus types 2 and 5, Gene 10:47.PubMedGoogle Scholar
  224. Stillman, B.W., Lewis, J.B., Chow, L.T., Mathews, M.B., and Smart, J.E., 1981, Identification of the gene and mRNA for the adenovirus terminal protein precursor, Cell 23:497.PubMedGoogle Scholar
  225. Sugisaka, H., Sugimoto, K., Takanami, M., Shiroki, K., Saito, I., Shimojo, H., Sawada, Y., Uemizu, Y., Uesigi, S.-L, and Fujinaga, K., 1980, Structure and gene organization in the transforming HindIII-G fragment of Adl2, Cell 20:777.Google Scholar
  226. Sussenbach, J.S., Ellens, D.J., and Jansz, H.S., 1973, Studies on the mechanism of adenovirus DNA replication. II. The nature of single-stranded DNA in replicative intermediates,J. Virol 12:1131.PubMedGoogle Scholar
  227. Tamanoi, F., and Stillman, B.W., 1982, Function of adenovirus terminal protein in the initiation of DNA replication, Proc. Natl. Acad. Sci. U.S.A. 79:2221.PubMedGoogle Scholar
  228. Tate, V.E., and Philipson, L., 1979, Parental adenovirus DNA accumulates in nucleosome-like structures in infected cells, Nucleic Acids Res. 6:2769.PubMedGoogle Scholar
  229. Temple, M., Antoine, G., Delius, H., Stahl, S., and Winnacker, E.L., 1981, Replication of mouse adenovirus strain FL DNA, Virology 109:1.PubMedGoogle Scholar
  230. Tibbetts, C., 1977, Physical organization of subgroup B human adenoviruses genomes,J. Virol. 24:564.PubMedGoogle Scholar
  231. Tibbetts, C., and Pettersson, U., 1974, Complementary strand-specific sequences from unique fragments of adenovirus type 2 DNA for hybridization mapping experiments,J. Mol. Biol. 88:767.PubMedGoogle Scholar
  232. Tibbetts, C., Johansson, K., and Philipson, L., 1973, Hydroxylapatite chromatography and formamide denaturation of adenovirus DNA,J. Virol. 12:218.PubMedGoogle Scholar
  233. Tibbetts, C., Pettersson, U., Johansson, K., and Philipson, L., 1974, Transcription of the adenovirus type 2 genome. I. Relationship of cytoplasmic RNA to the complementary strands of viral DNA,J. Virol. 13:370.PubMedGoogle Scholar
  234. Tokunaga, O., Shinagawa, M., and Padmanabhan, R., 1982, Physical mapping and sequence analysis at the inverted terminal repetition of adenovirus type 4, Gene 18:329.PubMedGoogle Scholar
  235. Tolun, A., Aleström, P., and Pettersson, U., 1979, Sequence of inverted terminal repetitions from different adenoviruses: Demonstration of conserved sequences and homology between SA7 and SV40 DNA, Cell 17:705.PubMedGoogle Scholar
  236. Tooze, J.(ed.), 1981, The Molecular Biology of Tumor Viruses, 2nd rev. ed., Part 10B, DNA Tumor Viruses, Cold Spring Harbor Press, Cold Spring Harbor, New York.Google Scholar
  237. Trentin, J.J., Yabe, Y., and Taylor, G., 1962, The quest for human cancer viruses, Science 137:835.PubMedGoogle Scholar
  238. van Beveren, C.P., Maat, J., Dekker, B.M.M., and van Ormondt, H., 1981, The nucleotide sequence of the gene for protein IVa2 and of the 5′ leader segment of the major late mRNA’s of adenovirus type 5, Gene 16:179.PubMedGoogle Scholar
  239. van den Elsen, P., de Pater, S., Houweling, A., Van der Veer, J., and van der Eb, A.J., 1982, The relationship between region E1A and E1B of human adenoviruses in cell transformation, Gene 18:175.PubMedGoogle Scholar
  240. van der Eb, A.J., and van Kesteren, L.W., 1966, Structure and molecular weight of the DNA of adenovirus type 5, Biochim. Biopys. Acta 129:441.Google Scholar
  241. van der Eb, A.J., van Kesteren, L.W., and van Bruggen, E.F.J., 1969, Structural properties of adenovirus DNAs, Biochim. Biopys. Acta 182:530.Google Scholar
  242. van der Eb, A.J., Mulder, C., Graham, F., and Houweling, A., 1977, Transformation with specific fragments of adenovirus DNA. I. Isolation of specific fragments with transforming activity of adenoviruses 2 and 5 DNA, Gene 2:115.PubMedGoogle Scholar
  243. van der Eb, A.J., van Ormondt, H., Schrier, P.I., Lupker, J.H., Jochemsen, H., van den Elsen, P.J., Deleys, R.J., Maat, J., van Beveren, C.P., Dijkema, R., and de Waard, A., 1979, Structure and function of the transforming genes of human adenoviruses and SV40, Cold Spring Harbor Symp. Quant. Biol. 44:383.Google Scholar
  244. van der Vliet, P.C., and Levine, A.J., 1973, DNA-binding proteins specific for cells infected by adenovirus, Nature (London) New Biol. 246:170.Google Scholar
  245. van der Vliet, P.C., and Sussenbach, J.S., 1975, An adenovirus type 5 gene function required for initiation of viral DNA replication, Virology 67:415.PubMedGoogle Scholar
  246. van der Vliet, P.C., Levine, A.J., Ensinger, M., and Ginsberg, H.S., 1975, Thermolabile DNA-binding proteins from cells infected with a temperature-sensitive mutant of adenovirus defective in viral DNA synthesis,J. Virol. 15:348.Google Scholar
  247. van der Vliet, P.C., Zandberg, J., and Jansz, H.S., 1977, Evidence for a function of the adenovirus DNA-binding protein in initiation of DNA synthesis as well as in elongation of nascent DNA chains, Virology 80:98.PubMedGoogle Scholar
  248. van Ormondt, H., Maat, J., de Waard, A., and van der Eb, A.J., 1978, The nucleotide sequence of the transforming HpaI-E fragment of adenovirus type 5 DNA, Gene 4:309.PubMedGoogle Scholar
  249. van Ormondt, H., Maat, J., and van Beveren, C.P., 1980a, The nucleotide sequence of the transforming region E-1 of adenovirus type 5 DNA, Gene 11:299.PubMedGoogle Scholar
  250. van Ormondt, H., Maat, J., and Dijkema, R., 1980b, Comparison of nucleotide sequences of the early E1A regions for subgroups A, B and C of human adenoviruses, Gene 12:63.PubMedGoogle Scholar
  251. van Wielink, P.S., 1978, A DNA-protein complex from adenovirus type 5 and its possible role in viral DNA replication, Academic thesis, State University of Utrecht, Utrecht.Google Scholar
  252. Varsanyi, T.M., Winberg, G., and Wadell, G., 1977, DNA restriction site mapping of adenovirus type 16 with BamI, EcoRI, Hpal and SalI. FEBS Lett. 76:151.PubMedGoogle Scholar
  253. Vennström, B., Pettersson, U., and Philipson, L., 1978a, Initiation of transcription in nuclei isolated from adenovirus-infected cells, Nucleic Acids Res. 5:205.PubMedGoogle Scholar
  254. Vennström, B., Pettersson, U., and Philipson, L., 1978b, Two initiation sites for adenovirus 5.5S RNA, Nucleic Acids Res. 5:195.PubMedGoogle Scholar
  255. Virtanen, A., Pettersson, U., Le Moullec, J.M., Tiollais, P., and Perricaudet, M., 1982a, Different mRNAs from the transforming region of highly oncogenic and non-oncogenic human adenoviruses, Nature (London) 295:705.Google Scholar
  256. Virtanen, A., Aleström, P., Persson, H., Katze, M.G., and Pettersson, U., 1982b, An adenovirus agnogene, Nucleic Acids Res. 10:2539.PubMedGoogle Scholar
  257. Vlak, J.M., Rozijn, T.H., and Sussenbach, J.S., 1975, Studies on the mechanism of replication of adenovirus DNA. IV. Discontinuous DNA chain propagation, Virology 63:168.PubMedGoogle Scholar
  258. Wadell, G., 1978, Classification of human adenoviruses by SDS-polyacrylamide gel electrophoresis of structural polypeptides, Intervirology 11:47.Google Scholar
  259. Weber, J., Bégin, M., and Khitto, G., 1975, Genetic analysis of adenovirus type 2. II. Preliminary phenotypic characterization of temperature-sensitive mutants,J. Virol. 15:1049.PubMedGoogle Scholar
  260. Weinmann, R., Raskas, H.J., and Roeder, R.G., 1974, Role of DNA-dependent RNA polymerases II and III in transcription of the adenovirus genome late in productive infection, Proc. Natl. Acad. Sci. U.S.A. 71:3436.Google Scholar
  261. Weinmann, R., Brendler, T.G., Raskas, H.J., and Roeder, R.G., 1976, Low molecular weight viral RNA’s transcribed by RNA polymerase III during adenovirus 2 infection, Cell 7:5577.Google Scholar
  262. Westphal, H., and Lai, S.-P., 1977, Quantitative electron microscopy of adenovirus RNA,J. Mol. Biol. 116:525.PubMedGoogle Scholar
  263. Westphal, H., Meyer, J., and Maizel, J.V., Jr., 1976, Mapping of adenovirus 2 mRNA by electron microscopy, Proc. Natl. Acad. Sci. U.S.A. 73:2069.PubMedGoogle Scholar
  264. Wilson, M.C., Fraser, N.W., and Darnell, J.E., 1979, Mapping of DNA initiation sites by high doses of ultraviolet irradiation: Evidence for three independent promoters within the left 11% of the Ad-2 genome, Virology 94:15.Google Scholar
  265. Winberg, G., and Hammarskjöld, M.L., 1980, Isolation of DNA from agarose gels using DEAE paper: Application to restriction site mapping of adenovirus type 16 DNA, Nucleic Acids Res. 8:253.PubMedGoogle Scholar
  266. Wolfson, J., and Dressler, D., 1972, Adenovirus DNA contains an inverted terminal redundancy, Proc. Natl. Acad. Sci. U.S.A. 69:3054.PubMedGoogle Scholar
  267. Wu, M., Roberts, R.J., and Davidson, N., 1977, Structure of the inverted terminal repetition of adenovirus type 2 DNA,J. Virol. 21:766.PubMedGoogle Scholar
  268. Younghusband, H.B., and Bellett, A.J.D., 1971, Mature form of DNA from chicken embryo lethal orphan virus,J. Virol. 8:265.PubMedGoogle Scholar
  269. Zain, B.S., and Roberts, R.J., 1979, Sequences from the beginning of the fiber messenger RNA of adenovirus-2,J. Mol. Biol. 131:341.PubMedGoogle Scholar
  270. Zain, S., Sambrook, J., Roberts, R.J., Keller, W., Fried, M., and Dunn, A.R., 1979a, Nucleotide sequence analysis of the leader segments in a cloned copy of adenovirus 2 fiber mRNA, Cell 16:851.PubMedGoogle Scholar
  271. Zain, S., Gingeras, T.R., Bullock, P., Wong, G., and Gelinas, R.E., 1979b, Determination and analysis of adenovirus-2 DNA sequences which may include signals for late mRNA processing, J. Mol. Biol. 135:413.PubMedGoogle Scholar
  272. Ziff, E.B., and Evans, R.M., 1978, Coincidence of the promoter and capped 5′ terminus of RNA from the adenovirus 2 major late transcription unit, Cell 155:1463.Google Scholar
  273. Ziff, E.B., and Fraser, N., 1978, Adenovirus type 2 late mRNA; Structural evidence for 3′-coterminal species.J. Virol. 25:897.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • John S. Sussenbach
    • 1
  1. 1.Laboratory for Physiological ChemistryState University of UtrechtGG UtrechtThe Netherlands

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