Superoxide Generation by Clastogenic Factors
Chromosome breakage factors or clastogenic factors (CF) were first described by radiobiologists, who reported a chromosome damaging effect of plasma from irradiated persons (for review see 1). These authors insisted on the long lasting nature of this phenomenon and suggested that CF may be risk factors in the development of late neoplasias resulting from therapeutic or accidental irradiaton. Renewed interest in diffusable CF paralleled the recognition of clastogenic activity in the plasma of patients with the socalled congenital breakage syndromes, ataxia telangiectasia (2) and Bloom’s syndrome (3), and in acquired diseases with increased chromosome damage, such as chronic inflammatory diseases of the connective tissue, the intestinal tract and the nervous system (for review see 4). CF may be isolated not only from plasma, but also from synovial fluid and cerebrospinal liquor.
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