Ca/CaM-Stimulated and cGMP-Specific Phosphodiesterases in Vascular and Non-Vascular Tissues
A large body of evidence indicates that guanosine 3’,5’-cyclic monophosphate (cGMP) plays an essential role in vasorelaxant actions of various agents such as atrial natriuretic factor (ANF), nitrogen oxide containing compounds (e.g., nitroprusside) and endothelium dependent vasodilators (e.g., acetylcholine) (1). These agents elevate cGMP by stimulating either soluble or particulate guanylate cyclase (1).
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