Regulation of the Glucose Transporter in Animal Models of Diabetes

  • Jeffrey E. Pessin
  • Jeanne M. Richardson
  • William I. Sivitz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)


Glucose oxidation, a major source of metabolic energy for mammalian cells, depends upon the transport of glucose across the cell surface membrane by specific carrier proteins. Two general classes of glucose transporters are found in mammalian cells. The first category of glucose transporters are the Na+/dependent glucose co-transporters which are found in the brush border membrane of epithelial cells in the small intestine and proximal tubule of the kidney.1 These carriers actively transport glucose from the lumen into the epithelial cell against its concentration gradient by coupling the uphill movement of glucose with the downhill movement of Na+ across its concentration gradient. The necessary Na+ gradient for this transport process is maintained by the Na+/K+ATPase found on the basolateral membrane of these epithelial cells.


Glucose Transporter GLUT4 Expression GLUT4 Glucose Transporter GLUT4 mRNA Glucose Transporter Protein 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Jeffrey E. Pessin
    • 1
  • Jeanne M. Richardson
    • 1
  • William I. Sivitz
    • 1
  1. 1.Departments of Physiology & Biophysics and Internal MedicineThe University of Iowa College of MedicineIowa CityUSA

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