Purification and Properties of Baboon Corneal Aldehyde Dehydrogenase: Proposed UVR Protective Role

  • Elizabeth M. Algar
  • Mahin Abedinia
  • John L. VandeBerg
  • Roger S. Holmes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 284)


The mammalian cornea plays an important role in protecting the eye from ultra-violet radiation (UVR) induced damage, particularly photosensitive retinal cells and the lens, by the absorption of UVR in the 290–320 nm wavelength range (UV-B) (Boettner and Wolters, 1962; Zigman, 1983). The mechanisms of corneal photoreception of UV-B light have not been determined, as yet, although studies examining the action spectra for the cornea in the induction of photokeratitis, have suggested the major involvement of a soluble protein in this process (Cogan and Kinsey, 1946; see Ringvold, 1980) . Photobiological processes in the cornea, arising from UV-B absorption, have also not been described. Recent studies by Stephens et al (1989) have indicated, however, that lipid peroxidation may account for phototoxicity in the retina, via the generation of peroxidic aldehydes, which are the cytotoxic products of lipid peroxidation (see Esterbauer et al, 1988).


Aldehyde Dehydrogenase Papio Hamadryas Percent Acetic Acid Corneal Extract Bovine Enzyme 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Elizabeth M. Algar
    • 1
  • Mahin Abedinia
    • 1
  • John L. VandeBerg
    • 2
  • Roger S. Holmes
    • 1
  1. 1.Division of Science and TechnologyGriffith University NathanBrisbaneAustralia
  2. 2.Department of GeneticsSouthwest Foundation for Biomedical ResearchSan AntonioUSA

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