Vacuolar Degeneration Induced by JHM-CC Virus in the CNS of Cyclophosphamide-Treated Mice

  • Yuzo Iwasaki
  • Norio Hirano
  • Tetsuro Tsukamoto
  • Satoru Haga
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


The infection with JHM-CC virus (1), a small plaque mutant of neuro-virulent JHM virus, is non-fatal in immunocompetent mice but constantly induces vacuolar degeneration in the brain and spinal cord (2). To elucidate the role of host immune response in pathogenesis of JHM-CC induced vacuolar degeneration in the central nervous system (CNS), the kinetics of virus growth and the temporal sequence of viral antigen distribution were correlated with histopathological changes in cyclophosphamide-treated adult ICR mice.


Olfactory Bulb Viral Antigen Mitral Cell Central Nervous System Tissue Immunocompetent Mouse 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Yuzo Iwasaki
    • 1
  • Norio Hirano
    • 2
  • Tetsuro Tsukamoto
    • 3
  • Satoru Haga
    • 2
  1. 1.Department of Neurological SciencesTohoku University School of MedicineSendaiJapan
  2. 2.Department of Veterinary MicrobiologyIwate UniversityMoriokaJapan
  3. 3.Department of NeurologyFukushima Medical CollegeFukushimaJapan

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