Reproductive Disorders in Female SHR Rats Infected with Sialodacryoadenitis Virus

  • Kenjiro Utsumi
  • Yutaka Yokota
  • Takashi Ishikawa
  • Kunio Ohnishi
  • Kosaku Fujiwara
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


Effects of sialodacryoadenitis virus infection on the reproduction of female SHR rats were studied. The oestrous cycle was considerably perturbed in most infected rats, the perturbation was observed initially between Days 0 to 10 post infection and the effect persisted for 6 to 18 days. About half of the foetuses of dams infected on Day 0 of gestation were found dead while only 4% of the foetuses from non-infected dams were found dead. Five or six days after infection on Day 0 of gestation, some infected dams were shown to have metritis, and virus antigen was detectable within the endometrium as well as exudate cells. In dams infected on Day 5 or later of gestation and severely diseased, the offspring showed a low survival rate possibly because of inadequate nursing.


Infectious Bronchitis Virus Oestrous Cycle Mouse Hepatitis Virus Embryonic Death Pregnant Uterus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    K. Fujiwara, S. Tanaka and S. Shumiya, Carrier state of antibodies and viruses in a mouse breeding colony persistently infected with Sendai and mouse hepatitis virus, Lab. An im. Sci., 26: 153 (1976).Google Scholar
  2. 2.
    H. Iwai, T. Ito, J. Yamanaka, Y. Ishihara, and S. Shumiya, Sero-epidemiological observation on mouse hepatitis virus in a mouse breeder colony, Exp. Anim., 22:259 (1973).Google Scholar
  3. 3.
    K. Katami, F. Taguchi, M. Nakayama, N. Goto, and K. Fujiwara, Vertical transmission of mouse hepatitis virus infection in mice, Jpn. J. Exp. Med., 48:481 (1978).PubMedGoogle Scholar
  4. 4.
    K. Utsumi, T. Ishikawa, T. Maeda, S. Shimizu, H. Tatsumi, and K. Fujiwara, Infectious sialodacryoadenitis and rat breeding, Lab. Anim. 14:303 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    A. Nagaoka, K. Kikuchi, and Y. Arakawa, Production of specific pathogen free spontaneously hypertensive rats, Jpn. J. Const. Med., 30:135 (1967).Google Scholar
  6. 6.
    K. Fujiwara, Y. Tanishima, and M. Tanaka, Seromonitoring of laboratory mouse and rat colonies for common murine pathogens, Exp. Anim., 28:297 (1979).Google Scholar
  7. 7.
    R. Yamaguchi, F. Taguchi, A. Yamada, K. Utsumi, and K. Fujiwara, Pathogenicity of sialodacryoadenitis virus for rats after brain passages in suckling mice, Jpn. J. Exp. Med., 52:45 (1982) .PubMedGoogle Scholar
  8. 8.
    N. Hirano, Y. Suzuki, K. Ono, T. Murakami, and K. Fujiwara, Growth of rat sialodacryoadenitis virus in LBC cell culture, Jpn. J. Vet. Sci., 48:93 (1986).Google Scholar
  9. 9.
    S. M. Hsu, and L. Raine, The use of avidin-biotin-peroxydase complex (ABC) in diagnostic and research pathology, in: “Advances in Immunohistochemistry ”, R. A. Delellis, ed., Masson Publ. USA, New York (1984).Google Scholar
  10. 10.
    M. Nakagawa, M. Saito, E. Suzuki, K. Nakayama, J. Matsubara, and T. Muto, Ten-years-long survey on pathogen status of mouse and rat breeding colonies, Exp. Anim., 33:115 (1984).Google Scholar
  11. 11.
    K. Utsumi, T. Maeda, H. Tatsumi, and K. Fujiwara, Some clinical and epizootiological observation of infectious sialoadenitis in rats, Exp. Anim.27:283 (1978).Google Scholar
  12. 12.
    D. G. Brownstein, and S. W. Barthold, Mouse hepatitis virus immunofluorescence in formalin-or Bouins-fixed tissues using trypsin digestion, Lab. Anim. Sci ., 32:37 (1982).PubMedGoogle Scholar
  13. 13.
    N. Takeichi, Development of auto-antibodies in spontaneously hypertensive rats (SHR), Metabol. Dis., 20:997 (1983).Google Scholar
  14. 14.
    K. Tuch, T. Matthiesen, and F. Helm, Sialoadenitis in spontaneously hypertensive rats, Z. Versuchstierk. , 19:40 (1977) .Google Scholar
  15. 15.
    R. O. Jacoby, P. N. Bhatt, and A. M. Jonas, Pathogenesis of sialodacryoadenitis in gnotobiotic rats, Vet. Pathol.,12:196 (1975) .PubMedGoogle Scholar
  16. 16.
    M. Maru, and K. Sato, Characterization of a Coronavirus isolated from rats with sialoadenitis, Arch. Virol., 73:33 (1982) .PubMedCrossRefGoogle Scholar
  17. 17.
    M. S. Hofstad, Avian infectious bronchitis, in: “Diseases of Poultry, 6th ”, M. S. Hoisted, ed., Iowa State Univ. Press, Ames (1972).Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Kenjiro Utsumi
    • 1
  • Yutaka Yokota
    • 1
  • Takashi Ishikawa
    • 1
  • Kunio Ohnishi
    • 1
  • Kosaku Fujiwara
    • 2
  1. 1.Research LaboratoriesDainippon Pharmaceutical Ltd.SuitaJapan
  2. 2.Nihon University School of Veterinary MedicineFujisawaJapan

Personalised recommendations