Investigations into Resistance of Chicken Lines to Infection with Infectious Bronchitis Virus

  • Jane Cook
  • Koichi Otsuki
  • Michael Huggins
  • Nat Bumstead
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


Although nine inbred and partially inbred lines of chickens were equally susceptible initially to infection with infectious bronchitis virus (IBV), the outcome of that infection varied considerably between the lines. A more detailed study of a line which was resistant (line C) and one which was highly susceptible (line 151) confirmed that both lines could be infected initially with IBV but showed that the respiratory tract epithelium of line C chicks recovered more rapidly than that of line 151 chicks. Whereas more virus could be recovered from tissues of line 15I chicks following IBV inoculation, explants of tissues from each line inoculated in vitro appeared equally susceptible. The possibility of a different immunological response to IBV infection in the two lines is discussed and it is clear that further work is required to elucidate the mechanism involved in the differing susceptibility of the inbred chicken lines to inoculation with IBV.


Inbred Line Infectious Bronchitis Virus Tracheal Epithelium Ciliary Activity Intranasal Inoculation 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Jane Cook
    • 1
  • Koichi Otsuki
    • 1
  • Michael Huggins
    • 1
  • Nat Bumstead
    • 1
  1. 1.Houghton LaboratoryIAH Institute for Animal HealthHoughton, Huntingdon CambridgeshireUK

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