RNA Sequence Analysis of the E2 Genes of Wildtype and Neuroattenuated Mutants of MHV-4 Reveals a Hypervariable Domain

  • Suezanne E. Parker
  • Michael J. Buchmeier
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


Murine hepatitis virus 4 (MHV-4) is a neurotropic Coronavirus (1–4). Infection of the CNS in susceptible mice strains results in a fatal encephalitis with destruction of neurons accompanied by demyelination. The few mice that survive the acute infection develop a chronic demyelinating disease characterized by episodes of demyelination followed by remyelination (2,5). The extensive white matter disease is believed to arise as the consequence of viral infection and destruction of oligodendrocytes (2,3,6).


Mouse Hepatitis Virus Fatal Encephalitis Susceptible Mouse Strain Hepatitis Virus Type Chronic Demyelinating Disease 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Suezanne E. Parker
    • 1
  • Michael J. Buchmeier
    • 1
  1. 1.Department of NeuropharmacologyScripps Clinic and Research FoundationLa JollaUSA

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