Biosynthesis and Function of the Coronavirus Spike Protein

  • H. Vennema
  • P. J. M. Rottier
  • L. Heijnen
  • G. J. Godeke
  • M. C. Horzinek
  • W. J. M. Spaan
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


One of the most interesting aspects of Coronavirus replication is their intracellular assembly. Budding is localized in the ER-pre Golgi region (8, 26). Both Coronavirus glycoproteins are synthesized in the RER on membrane bound ribosomes (16). The integral membrane protein (M) accumulates in the perinuclear region and is believed to determine the site of budding. The spike protein (S) mediates binding of virions to the host cell receptor, possesses a fusogenic activity and is the major target for virus neutralizing antibodies (22). The primary nucleotide sequence and the predicted amino acid sequence of a number of spike protein genes revealed features characteristic of type I membrane proteins (22).


Infectious Bronchitis Virus Recombinant Vaccinia Virus Mouse Hepatitis Virus Spike Protein Chase Period 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • H. Vennema
    • 1
  • P. J. M. Rottier
    • 1
  • L. Heijnen
    • 1
  • G. J. Godeke
    • 1
  • M. C. Horzinek
    • 1
  • W. J. M. Spaan
    • 1
  1. 1.Department of Virology, Faculty of Veterinary MedicineState University of UtrechtUtrechtThe Netherlands

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