Background Paper Progress Towards a Coronavirus Recombinant DNA Vaccine

  • Willy J. M. Spaan
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


During the last decade recombinant DNA technology has been successfully applied to the development of ‘new’ vaccines. Although there are many examples of successful vaccines which have been developed using the ‘classical approach’ e.g. inactivated, attenuated and subunit vaccines, the demand for a new generation of vaccines is evident. The risk of the escape of a pathogen from a vaccine production facility, the difficulties associated with the production of viral subunits, the high mutation frequency observed in many RNA viruses and the possibility of genetic reassortment and recombination have stimulated researchers to explore new avenues of vaccine biotechnology.


Vaccinia Virus Recombinant Feline Infectious Peritonitis High Mutation Frequency Antibody Dependent Enhancement Genetic Reassortment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Willy J. M. Spaan
    • 1
  1. 1.Institute of Infectious Diseases and Immunology, Department of Virology, Veterinary FacultyState University of UtrechtThe Netherlands

Personalised recommendations