Expression of MHV-A59 M Glycoprotein: Effects of Deletions on Membrane Integration and Intracellular Transport
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The M protein of coronaviruses is an integral membrane protein, the general properties of which have been described elsewhere in this volume. The protein is ascribed a pivotal role in the budding process of these viruses. Its restriction to internal membranes suggests it to be a major factor in determining the intracellular site of virion assembly. In addition, M is thought to effect budding through the interaction of its cytoplasmic tail with the nucleocapsid.
KeywordsMutant Protein Infectious Bronchitis Virus Recombinant Vaccinia Virus Feline Infectious Peritonitis Indirect Immunofluorescence Microscopy