Hyperuricemia and Gout in Cyclosporin A-Treated Renal Transplant Recipients

  • Hsiao-Yi Lin
  • Leslie L. Rocher
  • Mark A. McQuillan
  • Thomas D. Palella
  • Irving H. Fox
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)

Abstract

Hyperuricemia and gout have been reported in patients receiving cyclosporin therapy for immunosuppression after organ transplantation.1–5 We evaluated the frequency and mechanism of hyperuricemia during cyclosporine A therapy in a group of patients who had received a renal transplant.

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References

  1. 1.
    D.J. Tiller, B.M. Hall, J.S. Hovrarth, G.G. Duggin, J.F. Thompson, and A.G. Sheil, Gout and hyperuricemia in patients on cyclosporin and diuretics, Lancet 1: 453 (1985).PubMedCrossRefGoogle Scholar
  2. 2.
    A.G. Palestine, R.B. Nussenblat, and C.C. Chan, Side effects of systemic cyclosporin in patients not undergoing transplantation, Am. J. Med. 77: 652 (1984).PubMedCrossRefGoogle Scholar
  3. 3.
    J.R. Chapman, D. Griffiths, N.G. Harding, and P.J. Morris, Reversibility of cyclosporin nephrotoxicity after three month’s treatment, Lancet 1: 128 (1985).PubMedCrossRefGoogle Scholar
  4. 4.
    J.P. VanHooff, K.M.L. Leunissen, and W. vandeStaak, Cyclosporin, uric acid, and the kidney, Lancet 1: 701 (1985).Google Scholar
  5. 5.
    J.S. Najarian, D.S. Fryd, M. Strand, D.M. Canafax, N.L. Ascher, W.D. Payne, R.L. Simmons, and D.E. Futherland, A single institution randomized prospective trial of cyclosporin versus azathioprine — antilymphocyte globulin for immunosuppression in renal allograft recipients, Ann. Sura. 201: 142 (1985).CrossRefGoogle Scholar
  6. 6.
    N.L. Edwards, D. Recker, D. Airozo, and I.H. Fox, Enhanced purine salvage during allopurine therapy: an important pharmacologie property in humans, J. Lab. Clin. Med. 98: 673–683 (1981).PubMedGoogle Scholar
  7. 7.
    Z. Targhese, M.K. Chan, L.V. Steele, P. Sweny, O.N. Fernando, and J.F. Moorhead, How to measure cyclosporin, Lancet 1: 1407 (1984).CrossRefGoogle Scholar
  8. 8.
    R. Bianchi, C. Vitali, A. Clerico, A. Pilo, L. Riente, L. Fusani, and G. Mariani, Uric acid metabolism in normal subjects and in gouty patients by Chromatographic measurementof 14C-uric acid in plasma and urine, Metabolism (1979).Google Scholar
  9. 9.
    B.M. Hall, D.J. Tiller, I. Hardie, J. Mahony, T. Mathew, G. Thatcher, P. Miach, N. Thomson, and A.G. RossSheil, Comparison of three immunosuppressive regimens in cadaver renal transplantation: long-term cyclosporin, short-term cyclosporine followed by azathioprine and prednisolone, and azathioprine and prednisone withou;cyclosporine, N. Enal. J. Med. 318: 1499 (1988).CrossRefGoogle Scholar
  10. 10.
    B.D. Kahan, S.M. Flechner, M.I. Lorber, D. Golden, S. Conley, and C.T. Van Buren, Complication of cyclosporine-prednisone immunosuppression in 402 renal allograft recipients exclusively followed at a single center from one to five years, Transplantation 43: 197 (1987).PubMedCrossRefGoogle Scholar
  11. 11.
    S.L. Cohen, G. Boner, J.B. Rosenfeld, D. Shmuel, O. Sperling, A. Yusim, A. Todd-Pokropek, and Z. Shapira, The mechanism of hyperuricemia in cyclosporin-treated renal transplant recipients, Transplant Proc. 1829 (1987).Google Scholar
  12. 12.
    C. West, B.J. Carpenter, and T.R. Hakala. The incidence of gout in renal transplant recipients, Am. J. Kid. Dis. 10: 369 (1987).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Hsiao-Yi Lin
    • 1
  • Leslie L. Rocher
    • 1
  • Mark A. McQuillan
    • 1
  • Thomas D. Palella
    • 1
  • Irving H. Fox
    • 1
  1. 1.Human Purine Research Center Internal Medicine and Biological Chemistry Clinical Research CenterUniversity HospitalAnn ArborUSA

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