Mechanism of Antitumor Activity of Norspermidine, a Structural Homologue of Spermidine

  • Prasad S. Sunkara
  • John H. Zwolshen
  • Nellikunja J. Prakash
  • Terry L. Bowlin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 250)


The availability of α-difluoromethylornithine (DFMO), a specific and irreversible inhibitor of ornithine decarboxylase (ODC) made it possible to demonstrate an essential role for polyamines in cell proliferation and differentiation.1, 2, 3 Polyamine depletion induced by DFMO treatment in a number of in vitro and in vivo model systems resulted in growth retardation4, 5, 6 and cell death.7, 8 Further, the remarkable low toxicity of DFMO and its significant antitumor and antimetastatic activity in experimental tumor models7, 10, 11 suggested that approaches aimed at perturbing polyamine metabolism should be explored in identifying novel antitumor agents.


HeLa Cell Ornithine Decarboxylase BeLa Cell Polyamine Metabolism Polyamine Biosynthesis 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Prasad S. Sunkara
    • 1
  • John H. Zwolshen
    • 1
  • Nellikunja J. Prakash
    • 1
  • Terry L. Bowlin
    • 1
  1. 1.Merrell Dow Research InstituteCincinnatiUSA

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