The Use of Neutrons to Show How Proteins Work

  • Anthony A. Kossiakoff
Conference paper
Part of the Basic Life Sciences book series (BLSC, volume 46)

Abstract

The previous discussions brought up questions about what progress into the understanding of how a protein structure confers its biological activity will be required to make use of the new information that will become available from DNA engineering activities. To fully use the sequence information, two criteria must be met: 1) the protein folding problem has to be solved, and 2) the biological roles of the proteins have to be identified. Although both of these points involve extremely ambitious goals, the protein-folding problem (that is, the rules governing atomic interactions and how they are related to the forming of tertiary structure) is one that will not be fully answered in the near term, given our current knowledge and our previous rate of progress. This is not to say, however, that some general principles of how proteins fold and work have not been established, quite the contrary. Yet, I believe a realistic view is that the long-term solution is a step by step approach, employing new experimental and theoretical methodologies.

Keywords

Neutron Diffraction Protein Engineering Sheet Structure Peptide Group Tetrahedral Intermediate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Anthony A. Kossiakoff
    • 1
  1. 1.Genentech Inc.So. San FranciscoUSA

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