Natural Killer (NK) Cell Activity Against Enteric Murine Coronavirus Mediated by Intestinal Leukocytes
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Relatively little is known about local cell mediated immunity (CMI) in the gut and its role in resistance to enteric virus disease. Intraepithelial leukocytes (IEL), because of their location within the epithelium, may be involved in the defense of the gut mucosa against viruses. This study was initiated to assess the endogenous local CMI response of murine mucosal lymphocytes, especially IEL, to an enveloped enteric murine virus. The Yale strain of mouse hepatitis virus (MHV-Y) was chosen for these studies. MHV-Y causes diarrhea in infant mice (1) and has been shown to be highly tropic for the intestinal epithelium (2). It repucates in NCTC-1469 cells which have the H-2k phenotype (3).