Endocytosis and Lysosomes: Recent Progress in Intracellular Traffic

  • J. B. Lloyd
Chapter
Part of the NATO ASI Series book series (NSSA, volume 113)

Abstract

The cell membrane is a formidable barrier to macromolecules, and one that is circumvented only by the phenomenon of endocytosis. Even then the endocytosed material is segregated in a membrane-bounded vesicle and does not have access to the general cytoplasm. Its ability to influence intracellular events depends on the routing of the vesicle (to the lysosome or elsewhere), the effects of the intravesicular and intralysosomal environments, and the permeability properties of the vesicle and lysosome membranes. My remit is to review the current understanding of this area of cell biology, which is pivotal for attempts to target drugs with synthetic systems. Because of the focus of this symposium, I omit consideration of some related issues, such as the biogenesis of lysosomal enzymes (but see references 1 and 2 for reviews). The area remaining is however both extensive and active and, to avoid an unwieldy bibliography, I cite review articles where available plus some selected recent primary research papers.

Keywords

Lysosomal Enzyme Ciba Foundation Symposium Cationic Amino Acid Transport Membrane Movement Membrane Recycling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. B. Lloyd
    • 1
  1. 1.Biochemistry Research Laboratory, Department of Biological SciencesUniversity of KeeleStaffordshireEngland

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