Defenses Against Aflatoxin Carcinogenesis in Humans

  • M. Sid Masri
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 177)

Abstract

Aspects of work on aflatoxin mainly from the author’s studies are discussed, emphasizing procedures, strategies and insights related to protection against aflatoxin carcinogenesis in man due to transmission in the food chain. Five lines of defense are discussed. First, is the interfacing of the farm animal as a biologic filter between contaminated crop (feed) and human food derived from animal products. Second, is chemical detoxification of meals with ammonia and of contaminated milk by ultraviolet light. Third is prevention of mold growth and aflatoxin elaboration with ammonium carbonate for potential application during storage and drying of agricultural products. Fourth, is the development of ultrasensitive analytical methods for aflatoxins with structural proof of identity. And, fifth are natural defenses related to the role of hydroxylation of mammalian metabolism in detoxification, especially the pathway to aflatoxin Q1, a major detoxifying mechanism in primates, and the epoxidation pathway and its relation to prevention of aflatoxin residue transmission into edible tissues.

Keywords

Mold Growth Ammonium Carbonate Peanut Meal Guanine Residue Methyl Sterculate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. Sid Masri
    • 1
  1. 1.Western Regional Research Center Agricultural Research ServiceU.S. Department of AgricultureAlbanyUSA

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