HLA Encoded Genes and Their Associations with Disease

  • G. Hauptmann
Chapter

Abstract

The relatively recent discovery concerning the situation of the structural loci for three major complement proteins: Factor B, C2 and C4 in the Major Histocompatibility Complex (MHC) gives a new dimension to this complex. The reasons for this association are still not clear but practical use has been made of the close linkage and the resulting linkage disequilibrium with the MHC genes for the exploration of the genetic control of the immune response and of the etiology and pathogeny of some HLA-associated diseases.

Keywords

Coeliac Disease Major Histocompatibility Complex Gene Complement Gene Idiopathic Membranous Nephropathy Protective Haplotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Mauff, G., Federmann, G. and Hauptmann, G., Immunobiol. 158: 96–100 (1980).CrossRefGoogle Scholar
  2. 2.
    O’Neill, G. J., Yang, S.Y., Tegoli, J., Berger, R. and Dupont, B., Nature 273: 668–670 (1978).PubMedCrossRefGoogle Scholar
  3. 3.
    Alper, C.A., Boenisch, T. and Watson, L., J. Exp. Med. 135: 68–80 (1972).PubMedCrossRefGoogle Scholar
  4. 4.
    Ohayon, E., Mouzon, A. De, Hauptmann, G., Klein, J., Abbal, M., Constans, J., Mayer, S. and Ducos, J., J. Immunogenet. 7: 441–445 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    Hobart, M.J. and Lachmann, P.J., Transplant. Rev. 32: 26–42 (1976).PubMedGoogle Scholar
  6. 6.
    Alper, C.A., J. Exp. Med. 144: 1111–1115 (1976).PubMedCrossRefGoogle Scholar
  7. 7.
    Meo, T., Atkinson, J., Bernoco, M., Bernoco, D. and Ceppellini, R., Eur. J. Immunol. 7: 916–919 (1976).CrossRefGoogle Scholar
  8. 8.
    Hauptmann, G., Tongio, M.M., Goetz, J., Mayer, S., Fauchet, R., Sobel, A., Griscelli, C., Berthoux, F., Rivat, C. and Rother, U., J. Immunogenet. 9: 127–132 (1982).PubMedCrossRefGoogle Scholar
  9. 9.
    O’Neill, G.J., Yang, S.Y. and Dupont, B., Proc. Natl. Acad. Sci. 75: 5165–5169 (1978).PubMedCrossRefGoogle Scholar
  10. 10.
    Awdeh, Z.L. and Alper, C.A., Proc. Nat. Acad. Sci. 77: 3576–3580 (1980).PubMedCrossRefGoogle Scholar
  11. 11.
    Rittner, Ch. and Bertrams, J., Hum. Genet. 56: 235–247 (1981).PubMedCrossRefGoogle Scholar
  12. 12.
    Cambon-de Mouzon, A., Ohayon, E., Ducos, J. and Hauptmann, G., Lancet 2: 1364 (1980).Google Scholar
  13. 13.
    Cambon-de Mouzon, A., Ohayon, E., Hauptmann, G., Sevin, A., Abbal, M,, Sommer, E., Vergnes, H., Ducos, J., Tissue Antilens 19: 366–379 (1982).CrossRefGoogle Scholar
  14. 14.
    Champsaur, H.F., Bottazzo, G.F., Bertrams, J., Assan, R. and Bach, Ch. J. Pediat. 100: 15–20 (1982).PubMedCrossRefGoogle Scholar
  15. 15.
    Kurtz, F., Hauptmann, G., Juif, J.G. and Bonardi, J.M., Arch. Franc. Pédiatr. 38: 543–545 (1981).Google Scholar
  16. 16.
    Trouillas, P., Berthoux, F., Boisson, D., Aimard, G. and Devic, M., Lancet 2: 1023 (1976).PubMedCrossRefGoogle Scholar
  17. 17.
    Dyer, P.A., Klouda, P.T., Harris, R. and Mallick, N.P., Tissue Antigens 15: 505–507 (1980).PubMedCrossRefGoogle Scholar
  18. 18.
    Tom, W. and Farid, N.R., Hum. Hered. 31: 227–231 (1981).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • G. Hauptmann
    • 1
  1. 1.Institut d’HématologieCentre de Transfusion SanguineStrasbourgFrance

Personalised recommendations