Regulation of Target Cell Responsiveness pp 361-390 | Cite as
Utilization of Lipoprotein-Carried Cholesterol for Steroidogenesis by Rat Luteal Tissue
Chapter
Abstract
Steroidogenic cells have the capacity to synthesize de novo the obligate precursor of their secretory products, cholesterol. However, it has become apparent that many glands rely upon extracellular sterol as substrate (Brown et al., 1979; Gwynne and Strauss, 1982; Strauss et al., 1981). This seems to be particularly true of tissues which secrete large quantities of steroid, such as the corpus luteum.
Keywords
Granulosa Cell Cholesteryl Ester Sterol Ester Luteal Cell Luteinized Granulosa Cell
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Preview
Unable to display preview. Download preview PDF.
References
- Andersen, J. M. and Dietschy, J. M., 1978, Relative importance of high and low density lipoproteins in the regulation of cholesterol synthesis in the adrenal gland, ovary and testis of the rat, J. Biol. Chem. 253:9024.PubMedGoogle Scholar
- Azhar, S., and Menon, K. M. J., 1981, Receptor-mediated gonadotropin action in the ovary. Rat luteal cells preferentially utilize and are acutely dependent upon the plasma-lipoprotein-supplied sterols in gonadotropinstimulated steroid production, J. Biol. Chem. 256:6548.PubMedGoogle Scholar
- Brown, M. S., Kovanen, P. T., and Goldstein, J. L., 1979, Receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex, Recent Prog. Hormone Res. 35:215.Google Scholar
- Carr, B. R., Sadler, R. K., Rochelle, D. B., Stalmach, M. A., MacDonald, P. C., and Simpson, E. R., 1981, Plasma lipoprotein regulation of progesterone biosynthesis by human corpus luteum in organ culture, J. Clin. Endocrinol. Metab. 52:875.PubMedCrossRefGoogle Scholar
- Christie, M. H., Gwynne, J. T., and Strauss, J. F. III, 1981, Binding of human high density lipoproteins to membranes of luteinized rat ovaries, J. Steroid Biochem. 14:671.PubMedCrossRefGoogle Scholar
- Christie, M. H., Strauss, J. F. III, and Flickinger, G. L., 1979, Effect of reduced blood cholesterol on sterol and steroid metabolism by rat luteal tissue, Endocrinology105:92.PubMedCrossRefGoogle Scholar
- Goldstein, J. L., and Brown, M. S., 1977, The low-density lipoprotein pathway and its relation to arteriosclerosis, Annu. Rev. Biochem. 46:897.PubMedCrossRefGoogle Scholar
- Gwynne, J. T., and Strauss, J. F. III, 1982, The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands, Endocrine Rev. 3:299.CrossRefGoogle Scholar
- Hirz, R., and Scanu, A. M., 1970, Reassembly in vitro of a serum high density lipoprotein, Biochem. Biophys. Acta207:364.PubMedGoogle Scholar
- Horikoshi, H., and Wiest, W. G., 1971, Interrelationships between estrogen and progesterone secretion and traumainduced deciduomata. On causes of uterine refractoriness in the “Parlow rat”, Endocrinology 89:807.PubMedCrossRefGoogle Scholar
- Kovanen, P. T., Brown, M. S., and Goldstein, J. L., 1979, Increased binding of low density lipoprotein to liver membranes from rats treated with 17 α-ethinyl estradiol, J. Biol. Chem. 254:11367.PubMedGoogle Scholar
- Osborne, J. C. Jr., and Brewer, H. B. Jr., 1977, The plasma lipoproteins, Adv. Prot. Chem. 31:253.CrossRefGoogle Scholar
- Rosenblum, M. F., Huttler, C. R., and Strauss, J. F. III, 1981, Control of sterol metabolism in cultured rat granulosa cells, Endocrinology 109:1518.PubMedCrossRefGoogle Scholar
- Savion, N., Laherty, R., Cohen, D., Lui, G. -M., and Gospodarowicz, D., 1982, The role of lipoproteins and 3-hydroxy-3-methylglutaryl coenzyme A reductase in progesterone production by cultured bovine granulosa cells, Endocrinology 110:13.PubMedCrossRefGoogle Scholar
- Schneider, W. J., Beisiegel, V., Goldstein, J. L., and Brown, M. S., 1982, Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight, J. Biol. Chem. 257:2664.PubMedGoogle Scholar
- Schreiber, J. R., Nakamura, K., and Weinstein, D. B., 1982, Degradation of rat and human lipoproteins by cultured rat ovary granulosa cells, Endocrinology 110:55.PubMedCrossRefGoogle Scholar
- Schuler, L. A., Langenberg, K. K., Gwynne, J. T., and Strauss, J. R. III, 1981a, High density lipoprotein utilization by dispersed rat luteal cells, Biochim. Biophys. Acta 664:583.PubMedGoogle Scholar
- Schuler, L. A., Scavo, L., Kirsch, T. M., Flickinger, G. L., and Strauss, J. F. III, 1979, Regulatioh of de novo biosynthesis of cholesterol and progestins, and formation of cholesteryl ester in rat corpus luteum by exogenous sterol, J. Biol. Chem. 254:8662.PubMedGoogle Scholar
- Schuler, L. A., Toaff, M. E., and Strauss, J. F. III, 1981b, Regulation of ovarian cholesterol metabolism. Control of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A; cholesterol acyltransferase, Endocrinology108:1476.PubMedCrossRefGoogle Scholar
- Strauss, J. F. III, MacGregor, L. C., and Gwynne, J. T., 1982, Uptake of high density lipoproteins by rat ovaries in vivoand dispersed ovarian cells in vitro. Direct correlation of high density lipoprotein uptake with steroidogenic activity, J. Steroid Biochem, 16:525.PubMedCrossRefGoogle Scholar
- Strauss, J. F., III, Schuler, L. A., Rosenblum, M. F., and Tanaka, T., 1981, Cholesterol metabolism by ovarian tissue, Adv. Lipid Res. 18:99.PubMedGoogle Scholar
- Tanaka, T., Billheimer, J. T., and Strauss, J. F. III, 1982, Luteinized rat ovaries contain a sterol binding protein similar to hepatic SCP . Abstracts, 64th Annual Meeting of the Endocrine Society, San Francisco, CA Abstract 402.Google Scholar
- Toaff, M. E., Schleyer, H., and Strauss, J. F. III, 1982, Metabolism of 25-hydroxycholesterol by rat luteal mitochondria and dispersed cells, Endocrinology111:1785.PubMedCrossRefGoogle Scholar
- Tureck, R. W., and Strauss, J. F. III, 1982, Progesterone synthesis by luteinized human granulosa cells in culture. The role of de novo sterol synthesis and lipoprotein-carried sterol, J. Clin. Endocrinol. Metab. 54:367.PubMedCrossRefGoogle Scholar
- Tureck, R. W., Wilburn, A. B., Gwynne, J. T., Paavola, L. G., and Strauss, J. F. III, 1983, The role of lipoproteins in steroidogenesis by human luteinized granulosa cells in culture, J. Steroid. Biochem. in press.Google Scholar
- Veldhuis, J. D., Klase, P. A., Gwynne, J. T., and Strauss, J. F. III, 1982, Low density lipoproteins (LDL) augment progesterone biosynthesis by swine granulosa cells in vitro: Relation of LDL effects to estrogen and gonadotropin action. Biol. Reprod. 26(Suppl. 1): 12.Google Scholar
Copyright information
© Plenum Press, New York 1984