The Na+, K+-Transporting Adenosine Triphosphatase

  • I. M. Glynn
Chapter

Abstract

The Na+,K+-transporting adenosine triphosphatase (Na+,K+-ATPase), also often known as the sodium pump or sodium-potassium pump, is an enzyme, found in nearly all animal-cell membranes, that uses energy from the hydrolysis of intracellular ATP to transport Na+ ions outwards and K+ ions inwards. It may be thought of as having three substrates (ATP, intracellular Na+ ions, and extracellular K+ ions) and four products (ADP, orthophosphate, extracellular Na+ ions, and intracellular K+ ions.) Because more Na+ ions are pumped out than K+ ions are pumped in, the activity of the enzyme generates an outward movement of positive charge, and this outward current may also be considered a “product” of the reaction.

Keywords

Cardiac Glycoside Adenosine Triphosphatase Sodium Pump Rectal Gland Ouabain Binding 
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© Plenum Press, New York 1985

Authors and Affiliations

  • I. M. Glynn
    • 1
  1. 1.Physiological LaboratoryUniversity of CambridgeCambridgeEngland

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