Design and Synthesis of Optically-Pure Compounds Using Microbial Systems
Chapter
Abstract
As the useful biological activities of most therapeutic agents are associated with only one enantiomer, the preparation of optically-pure compounds continues to be a major contemporary problem of synthetic organic chemistry. Because conventional chemical transformations generally give statistical mixtures of optical enantiomers, it is necessary to remove the unwanted antipode at the end of the reaction sequence by resolution using an asymmetric agent, which is often a natural product.
Keywords
Enantiomeric Excess Total Synthesis Optical Purity Kinetic Resolution Microbial System
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References and Notes
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© Plenum Press, New York 1983