Effect of LPS on Carbohydrate and Lipid Metabolism

  • Judy A. Spitzer
  • John J. Spitzer
Chapter

Abstract

Administration of endotoxin, a lipopolysaccharide (LPS) extracted from cell walls of gram-negative bacteria, elicits alterations in various metabolic parameters in many mammalian species, including man. Studies of the mechanism of metabolic alterations induced by LPS are important because release of endotoxin may contribute to the effects of sepsis, and clinical or experimental infections may alter the course of other types of trauma, shock, or injury. The overall metabolic and endocrine effects of endotoxicosis are predominantly catabolic. In general, the endocrine changes appear to be directed toward water and salt conservation, maintenance of blood pressure, and the mobilization of fuel primarily from carbohydrate stores. Eventually the breakdown of muscle protein follows, providing additional substrate for gluconeogenesis and satisfying the energy requirements of peripheral tissues and the brain.

Keywords

Adipose Tissue Myocardial Blood Flow Glucose Oxidation Blood Flow Restriction Endotoxin Shock 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Judy A. Spitzer
    • 1
  • John J. Spitzer
    • 1
  1. 1.Department of PhysiologyLouisiana State University Medical CenterNew OrleansUSA

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