Continuous Non Invasive Monitoring of Human Brain by Near Infrared Spectroscopy

  • M. Ferrari
  • I. Giannini
  • G. Sideri
  • E. Zanette
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


Precise time-and space-resolved measurement of brain energy metabolism and circulation in vivo would provide important information on the cerebral physiology and pathophysiology, Consequently different optoelectronic techniques based on spectroscopic signals of the normoxic-anoxic transition of pyridine nucleotide (NADH), flavoprotein (Fp) and cytochrome-c-oxidase (cyt a,a3) have been developed (Tab. 1). Cyt a,a3 which catalyzes more than 90% of cellular oxygen consumption, has a greater visible absorption in the reduced than in oxidized form; it is characterized by a broad band in the near infrared (I.R.) centered at 830 nm and attributable to the copper component of oxidized enzyme.


Near Infrared Spectroscopy Pyridine Nucleotide Spectral Contribution Brain Energy Metabolism Spectroscopic Signal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • M. Ferrari
    • 1
  • I. Giannini
    • 2
  • G. Sideri
    • 3
  • E. Zanette
    • 3
  1. 1.Laboratorio di Fisiopatologia di Organo e di SistemaIstituto Superiore di SanitàRomaItalia
  2. 2.ASSORENIMonterotondo, RomaItalia
  3. 3.Dipartimento di Scienze NeurologicheUniversità “La Sapienza” RomaItalia

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